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Effect of iron or multiple micronutrient supplements on the prevalence of anaemia among anaemic young children of a malaria-endemic area: a randomized double-blind trial.
Trop Med Int Health. 2008 Oct; 13(10):1257-66.TM

Abstract

OBJECTIVE

To assess the effect of supplementation with iron or multiple micronutrients (MM) on the prevalence of anaemia in a malaria-endemic area.

METHODS

A community-based randomized double-blind trial was conducted in rural Burkina Faso, including children aged 6-23 months with haemoglobin (Hb) concentrations of 70-109 g/l who were randomized into an iron group (Fe, n = 96), an iron and zinc group (IZ, n = 100) or an MM group (MM, n = 100), 5 days/week for 6 months. All children were provided with insecticide-treated bednets; those who had a Plasmodium falciparum (PF) positive-smear at baseline and/or at each monthly checking received antimalarial therapy.

RESULTS

The mean (SD) endpoint Hb concentration was higher in the MM group [113.2 (13.6) g/l] than in the IZ group [106.3 (15.6) g/l] and the Fe group [107.1 (12.9) g/l] (P = 0.001). Children in the MM group were more likely to recover from anaemia than those in the Fe group [prevalence rate ratios, PRR (95% confidence interval, CI) = 1.62 (1.22-2.15), P < 0.001]. The IZ group did not differ from the Fe group [PRR (95% CI) = 0.94 (0.65-1.35), P = 0.72]. None of the interactions on the effect of supplementation of baseline age (0.13), or baseline height-for-age z-score (P = 0.33), or incident PF parasitemia (P = 0.99), was significant.

CONCLUSION

In this malaria-endemic area, in combination with malaria management, the MM supplement was more efficacious than the Fe supplement and the IZ supplement for reducing anaemia. Further investigation into limiting factors and amounts of micronutrients that would be more efficacious for reducing anaemia is recommended.

Authors+Show Affiliations

Biomedical and Public Health Department, Institute of Research in Health Sciences, Ouagadougou, Burkina Faso. ouedher68@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18764815

Citation

Ouédraogo, Hermann Z., et al. "Effect of Iron or Multiple Micronutrient Supplements On the Prevalence of Anaemia Among Anaemic Young Children of a Malaria-endemic Area: a Randomized Double-blind Trial." Tropical Medicine & International Health : TM & IH, vol. 13, no. 10, 2008, pp. 1257-66.
Ouédraogo HZ, Dramaix-Wilmet M, Zeba AN, et al. Effect of iron or multiple micronutrient supplements on the prevalence of anaemia among anaemic young children of a malaria-endemic area: a randomized double-blind trial. Trop Med Int Health. 2008;13(10):1257-66.
Ouédraogo, H. Z., Dramaix-Wilmet, M., Zeba, A. N., Hennart, P., & Donnen, P. (2008). Effect of iron or multiple micronutrient supplements on the prevalence of anaemia among anaemic young children of a malaria-endemic area: a randomized double-blind trial. Tropical Medicine & International Health : TM & IH, 13(10), 1257-66. https://doi.org/10.1111/j.1365-3156.2008.02138.x
Ouédraogo HZ, et al. Effect of Iron or Multiple Micronutrient Supplements On the Prevalence of Anaemia Among Anaemic Young Children of a Malaria-endemic Area: a Randomized Double-blind Trial. Trop Med Int Health. 2008;13(10):1257-66. PubMed PMID: 18764815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of iron or multiple micronutrient supplements on the prevalence of anaemia among anaemic young children of a malaria-endemic area: a randomized double-blind trial. AU - Ouédraogo,Hermann Z, AU - Dramaix-Wilmet,Michèle, AU - Zeba,Augustin N, AU - Hennart,Philippe, AU - Donnen,Philippe, Y1 - 2008/08/24/ PY - 2008/9/4/pubmed PY - 2008/12/17/medline PY - 2008/9/4/entrez SP - 1257 EP - 66 JF - Tropical medicine & international health : TM & IH JO - Trop Med Int Health VL - 13 IS - 10 N2 - OBJECTIVE: To assess the effect of supplementation with iron or multiple micronutrients (MM) on the prevalence of anaemia in a malaria-endemic area. METHODS: A community-based randomized double-blind trial was conducted in rural Burkina Faso, including children aged 6-23 months with haemoglobin (Hb) concentrations of 70-109 g/l who were randomized into an iron group (Fe, n = 96), an iron and zinc group (IZ, n = 100) or an MM group (MM, n = 100), 5 days/week for 6 months. All children were provided with insecticide-treated bednets; those who had a Plasmodium falciparum (PF) positive-smear at baseline and/or at each monthly checking received antimalarial therapy. RESULTS: The mean (SD) endpoint Hb concentration was higher in the MM group [113.2 (13.6) g/l] than in the IZ group [106.3 (15.6) g/l] and the Fe group [107.1 (12.9) g/l] (P = 0.001). Children in the MM group were more likely to recover from anaemia than those in the Fe group [prevalence rate ratios, PRR (95% confidence interval, CI) = 1.62 (1.22-2.15), P < 0.001]. The IZ group did not differ from the Fe group [PRR (95% CI) = 0.94 (0.65-1.35), P = 0.72]. None of the interactions on the effect of supplementation of baseline age (0.13), or baseline height-for-age z-score (P = 0.33), or incident PF parasitemia (P = 0.99), was significant. CONCLUSION: In this malaria-endemic area, in combination with malaria management, the MM supplement was more efficacious than the Fe supplement and the IZ supplement for reducing anaemia. Further investigation into limiting factors and amounts of micronutrients that would be more efficacious for reducing anaemia is recommended. SN - 1365-3156 UR - https://www.unboundmedicine.com/medline/citation/18764815/Effect_of_iron_or_multiple_micronutrient_supplements_on_the_prevalence_of_anaemia_among_anaemic_young_children_of_a_malaria_endemic_area:_a_randomized_double_blind_trial_ L2 - https://doi.org/10.1111/j.1365-3156.2008.02138.x DB - PRIME DP - Unbound Medicine ER -