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Significantly higher frequencies of presence of serum autoantibodies in Chinese patients with oral lichen planus.
J Oral Pathol Med. 2009 Jan; 38(1):48-54.JO

Abstract

BACKGROUND

Previous studies have shown the presence of serum anti-nuclear (ANA), anti-smooth muscle (SMA), anti-mitochondrial (AMA), anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA) and anti-thyroid microsomal autoantibodies (TMA) in small groups of patients with oral lichen planus (OLP).

METHODS

In this study, the serum levels of ANA, SMA, AMA, GPCA, TGA and TMA were measured in a group of 320 Chinese OLP patients and 53 healthy control subjects to assess whether Chinese OLP patients had significantly higher frequencies of serum autoantibodies than healthy control subjects and to assess which risk factors had a significant influence on the possession of a specific serum autoantibody in OLP patients.

RESULTS

We found that autoantibodies were present in 195 (60.9%) of the 320 OLP patients. The frequencies of presence of serum ANA (28.1%), GPCA (26.3%), TGA (21.3%) and TMA (24.4%) in OLP patients were significantly higher than those (5.7%, 1.9%, 1.9% and 1.9%, respectively) in healthy control subjects (all P-values were < 0.005). Forty-one (12.8%) OLP patients also had anti-hepatitis C virus antibody (HCVA) in their sera. The multivariate logistic regression found that major erosive OLP (EOLP) [odds ratio (OR) = 1.786], TGA/TMA-positivity (OR = 2.517), and HCVA-positivity (OR = 2.214) were significant risk factors to influence ANA-positivity in OLP patients. Moreover, only major EOLP (OR = 1.879) and ANA-positivity (OR = 2.581) were significant risk factors to influence TGA/TMA-positivity in OLP patients.

CONCLUSIONS

There are significantly higher frequencies of presence of ANA, GPCA, TGA and TMA in Chinese OLP patients than in healthy control subjects.

Authors+Show Affiliations

School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18764857

Citation

Chang, Julia Yu-Fong, et al. "Significantly Higher Frequencies of Presence of Serum Autoantibodies in Chinese Patients With Oral Lichen Planus." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 38, no. 1, 2009, pp. 48-54.
Chang JY, Chiang CP, Hsiao CK, et al. Significantly higher frequencies of presence of serum autoantibodies in Chinese patients with oral lichen planus. J Oral Pathol Med. 2009;38(1):48-54.
Chang, J. Y., Chiang, C. P., Hsiao, C. K., & Sun, A. (2009). Significantly higher frequencies of presence of serum autoantibodies in Chinese patients with oral lichen planus. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 38(1), 48-54. https://doi.org/10.1111/j.1600-0714.2008.00686.x
Chang JY, et al. Significantly Higher Frequencies of Presence of Serum Autoantibodies in Chinese Patients With Oral Lichen Planus. J Oral Pathol Med. 2009;38(1):48-54. PubMed PMID: 18764857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significantly higher frequencies of presence of serum autoantibodies in Chinese patients with oral lichen planus. AU - Chang,Julia Yu-Fong, AU - Chiang,Chun-Pin, AU - Hsiao,Chuhsing Kate, AU - Sun,Andy, Y1 - 2008/08/31/ PY - 2008/9/4/pubmed PY - 2009/5/23/medline PY - 2008/9/4/entrez SP - 48 EP - 54 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J Oral Pathol Med VL - 38 IS - 1 N2 - BACKGROUND: Previous studies have shown the presence of serum anti-nuclear (ANA), anti-smooth muscle (SMA), anti-mitochondrial (AMA), anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA) and anti-thyroid microsomal autoantibodies (TMA) in small groups of patients with oral lichen planus (OLP). METHODS: In this study, the serum levels of ANA, SMA, AMA, GPCA, TGA and TMA were measured in a group of 320 Chinese OLP patients and 53 healthy control subjects to assess whether Chinese OLP patients had significantly higher frequencies of serum autoantibodies than healthy control subjects and to assess which risk factors had a significant influence on the possession of a specific serum autoantibody in OLP patients. RESULTS: We found that autoantibodies were present in 195 (60.9%) of the 320 OLP patients. The frequencies of presence of serum ANA (28.1%), GPCA (26.3%), TGA (21.3%) and TMA (24.4%) in OLP patients were significantly higher than those (5.7%, 1.9%, 1.9% and 1.9%, respectively) in healthy control subjects (all P-values were < 0.005). Forty-one (12.8%) OLP patients also had anti-hepatitis C virus antibody (HCVA) in their sera. The multivariate logistic regression found that major erosive OLP (EOLP) [odds ratio (OR) = 1.786], TGA/TMA-positivity (OR = 2.517), and HCVA-positivity (OR = 2.214) were significant risk factors to influence ANA-positivity in OLP patients. Moreover, only major EOLP (OR = 1.879) and ANA-positivity (OR = 2.581) were significant risk factors to influence TGA/TMA-positivity in OLP patients. CONCLUSIONS: There are significantly higher frequencies of presence of ANA, GPCA, TGA and TMA in Chinese OLP patients than in healthy control subjects. SN - 1600-0714 UR - https://www.unboundmedicine.com/medline/citation/18764857/Significantly_higher_frequencies_of_presence_of_serum_autoantibodies_in_Chinese_patients_with_oral_lichen_planus_ DB - PRIME DP - Unbound Medicine ER -