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A conjugated linoleic acid supplement containing trans-10, cis-12 conjugated linoleic acid reduces milk fat synthesis in lactating goats.
J Dairy Sci. 2008 Sep; 91(9):3291-9.JD

Abstract

The effect of conjugated linoleic acid (CLA) supplements containing trans-10, cis-12 for reducing milk fat synthesis has been well described in dairy cows and sheep. Studies on lactating goats, however, remain inconclusive. Therefore, the current study investigated the efficacy of a lipid-encapsulated trans-10, cis-12 CLA supplement (LE-CLA) on milk production and milk fatty acid profile in dairy goats. Thirty multiparous Alpine lactating goats in late lactation were used in a 3 x 3 Latin square design (14-d treatment periods separated by 14-d intervals). Does were fed a total mixed ration of Bermuda grass hay, dehydrated alfalfa pellets, and concentrate. Does were randomly allocated to 3 treatments: A) unsupplemented (control), B) supplemented with 30 g/d of LE-CLA (low dose; CLA-1), and C) supplemented with 60 g/d of LE-CLA (high dose; CLA-2). Milk yield, dry matter intake, and milk protein content and yield were unaffected by treatment. Compared with the control, milk fat yield was reduced 8% by the CLA-1 treatment and 21% by the CLA-2 treatment, with milk fat content reduced 5 and 18% by the CLA-1 and CLA-2 treatments, respectively. The reduction in milk fat yield was due to decreases in both de novo fatty acid synthesis and uptake of preformed fatty acids. Milk fat content of trans-10, cis-12 CLA was 0.03, 0.09, and 0.19 g/100 g of fatty acids for the control, CLA-1, and CLA-2 treatments, respectively. The transfer efficiency of trans-10, cis-12 CLA from the 2 levels of CLA supplement into milk fat was not different between treatments and averaged 1.85%. In conclusion, trans-10, cis-12 CLA reduced milk fat synthesis in lactating dairy goats in a manner similar to that observed for lactating dairy cows and dairy sheep. Dose-response comparisons, however, suggest that the degree of reduction in milk fat synthesis is less in dairy goats compared with dairy cows and dairy sheep.

Authors+Show Affiliations

Department of Animal Science, University of Vermont, Burlington 05405, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18765588

Citation

Lock, A L., et al. "A Conjugated Linoleic Acid Supplement Containing Trans-10, Cis-12 Conjugated Linoleic Acid Reduces Milk Fat Synthesis in Lactating Goats." Journal of Dairy Science, vol. 91, no. 9, 2008, pp. 3291-9.
Lock AL, Rovai M, Gipson TA, et al. A conjugated linoleic acid supplement containing trans-10, cis-12 conjugated linoleic acid reduces milk fat synthesis in lactating goats. J Dairy Sci. 2008;91(9):3291-9.
Lock, A. L., Rovai, M., Gipson, T. A., de Veth, M. J., & Bauman, D. E. (2008). A conjugated linoleic acid supplement containing trans-10, cis-12 conjugated linoleic acid reduces milk fat synthesis in lactating goats. Journal of Dairy Science, 91(9), 3291-9. https://doi.org/10.3168/jds.2008-1071
Lock AL, et al. A Conjugated Linoleic Acid Supplement Containing Trans-10, Cis-12 Conjugated Linoleic Acid Reduces Milk Fat Synthesis in Lactating Goats. J Dairy Sci. 2008;91(9):3291-9. PubMed PMID: 18765588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A conjugated linoleic acid supplement containing trans-10, cis-12 conjugated linoleic acid reduces milk fat synthesis in lactating goats. AU - Lock,A L, AU - Rovai,M, AU - Gipson,T A, AU - de Veth,M J, AU - Bauman,D E, PY - 2008/9/4/pubmed PY - 2008/12/17/medline PY - 2008/9/4/entrez SP - 3291 EP - 9 JF - Journal of dairy science JO - J Dairy Sci VL - 91 IS - 9 N2 - The effect of conjugated linoleic acid (CLA) supplements containing trans-10, cis-12 for reducing milk fat synthesis has been well described in dairy cows and sheep. Studies on lactating goats, however, remain inconclusive. Therefore, the current study investigated the efficacy of a lipid-encapsulated trans-10, cis-12 CLA supplement (LE-CLA) on milk production and milk fatty acid profile in dairy goats. Thirty multiparous Alpine lactating goats in late lactation were used in a 3 x 3 Latin square design (14-d treatment periods separated by 14-d intervals). Does were fed a total mixed ration of Bermuda grass hay, dehydrated alfalfa pellets, and concentrate. Does were randomly allocated to 3 treatments: A) unsupplemented (control), B) supplemented with 30 g/d of LE-CLA (low dose; CLA-1), and C) supplemented with 60 g/d of LE-CLA (high dose; CLA-2). Milk yield, dry matter intake, and milk protein content and yield were unaffected by treatment. Compared with the control, milk fat yield was reduced 8% by the CLA-1 treatment and 21% by the CLA-2 treatment, with milk fat content reduced 5 and 18% by the CLA-1 and CLA-2 treatments, respectively. The reduction in milk fat yield was due to decreases in both de novo fatty acid synthesis and uptake of preformed fatty acids. Milk fat content of trans-10, cis-12 CLA was 0.03, 0.09, and 0.19 g/100 g of fatty acids for the control, CLA-1, and CLA-2 treatments, respectively. The transfer efficiency of trans-10, cis-12 CLA from the 2 levels of CLA supplement into milk fat was not different between treatments and averaged 1.85%. In conclusion, trans-10, cis-12 CLA reduced milk fat synthesis in lactating dairy goats in a manner similar to that observed for lactating dairy cows and dairy sheep. Dose-response comparisons, however, suggest that the degree of reduction in milk fat synthesis is less in dairy goats compared with dairy cows and dairy sheep. SN - 1525-3198 UR - https://www.unboundmedicine.com/medline/citation/18765588/A_conjugated_linoleic_acid_supplement_containing_trans_10_cis_12_conjugated_linoleic_acid_reduces_milk_fat_synthesis_in_lactating_goats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-0302(08)71044-0 DB - PRIME DP - Unbound Medicine ER -