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Adjunctive aripiprazole decreased metabolic side effects of clozapine treatment.
Neuro Endocrinol Lett. 2008 Aug; 29(4):435-7.NE

Abstract

Clozapine is an atypical antipsychotic indicated for the treatment of refractory schizophrenia. Clozapine treatment is associated with the metabolic side effects. Weight gain, hyperlipidemia and hyperglycemia are the risk factors for onset of diabetes and cardiovascular disorders. We report a case vignette of a patient in whom the decrease in negative and general psychopathology after adjunctive aripiprazole appeared simultaneously with a reduction of clozapine-induced increase in weight and metabolic measures. Combined application of clozapine and aripiprazole is in accordance with a neurobiological rationale and appears to be a safe and well tolerated.

Authors+Show Affiliations

Charles University in Prague, Faculty of Medicine, Czech Republic. masopustj@lfhk.cuni.czNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18766167

Citation

Masopust, Jirí, et al. "Adjunctive Aripiprazole Decreased Metabolic Side Effects of Clozapine Treatment." Neuro Endocrinology Letters, vol. 29, no. 4, 2008, pp. 435-7.
Masopust J, Tůma I, Libiger J. Adjunctive aripiprazole decreased metabolic side effects of clozapine treatment. Neuro Endocrinol Lett. 2008;29(4):435-7.
Masopust, J., Tůma, I., & Libiger, J. (2008). Adjunctive aripiprazole decreased metabolic side effects of clozapine treatment. Neuro Endocrinology Letters, 29(4), 435-7.
Masopust J, Tůma I, Libiger J. Adjunctive Aripiprazole Decreased Metabolic Side Effects of Clozapine Treatment. Neuro Endocrinol Lett. 2008;29(4):435-7. PubMed PMID: 18766167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adjunctive aripiprazole decreased metabolic side effects of clozapine treatment. AU - Masopust,Jirí, AU - Tůma,Ivan, AU - Libiger,Jan, PY - 2008/03/27/received PY - 2008/05/13/accepted PY - 2008/9/4/pubmed PY - 2008/11/13/medline PY - 2008/9/4/entrez SP - 435 EP - 7 JF - Neuro endocrinology letters JO - Neuro Endocrinol. Lett. VL - 29 IS - 4 N2 - Clozapine is an atypical antipsychotic indicated for the treatment of refractory schizophrenia. Clozapine treatment is associated with the metabolic side effects. Weight gain, hyperlipidemia and hyperglycemia are the risk factors for onset of diabetes and cardiovascular disorders. We report a case vignette of a patient in whom the decrease in negative and general psychopathology after adjunctive aripiprazole appeared simultaneously with a reduction of clozapine-induced increase in weight and metabolic measures. Combined application of clozapine and aripiprazole is in accordance with a neurobiological rationale and appears to be a safe and well tolerated. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/18766167/Adjunctive_aripiprazole_decreased_metabolic_side_effects_of_clozapine_treatment_ DB - PRIME DP - Unbound Medicine ER -