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Variation of bispectral index monitoring in paediatric patients undergoing propofol-remifentanil anaesthesia.
Eur J Anaesthesiol. 2008 Oct; 25(10):821-5.EJ

Abstract

BACKGROUND AND OBJECTIVE

The technology of bispectral index monitoring is based on an algorithm developed from adults. This study was conducted to investigate the difference in bispectral index monitoring between paediatric and adult patients under intravenous anaesthesia.

METHODS

In all, 68 patients undergoing elective surgery were divided into three groups as follows: Group A (younger children, n = 20, 3 yr < or = yr < or = 5 yr), Group B (older children, n = 20, 6 yr < or = yr < or = 12 yr), Group C (adults, n = 28, 25 yr < or = yr < or = 50 yr). All patients were induced by plasma target-controlled infusion of propofol till loss of consciousness (loss of response to verbal commands and eyelash reflex). The plasma concentration (Cp(propofol)) and effect-site concentration (Ce(propofol)) of propofol and bispectral index values were compared at loss of consciousness and regaining of consciousness. During the operation, remifentanil was infused at a fixed rate of 0.25 microg kg (-1) min (-1), and the minute average bispectral index values of three groups were also compared at different stable concentrations of propofol (Ce(propofol) = Cp(propofol) = 2,3, 4 and 5 microg mL (-1), respectively).

RESULTS

At loss of consciousness and regaining of consciousness, the bispectral index values in Group A (loss of consciousness: 74.7 +/- 6.3, regaining of consciousness: 81.1 +/- 10.5) were significantly higher than those in Group C (loss of consciousness: 68.6 +/- 69.4, regaining of consciousness: 74.5 +/- 6.0) (P < 0.01). There was no statistical difference between Cp(propofol) in all groups at loss of consciousness and regaining of consciousness. The Ce(propofol) at loss of consciousness in Group A (3.57 +/- 0.60 microg mL (-1) and B (3.25 +/- 0.44 microg mL(-1)) were significantly higher than those in Group C (2.15 +/- 0.86 microg mL (-1)) (P < 0.01). At the same stable concentrations of propofol, the bispectral index values in Group A and B were significantly higher than those in Group C, and the bispectral index values in Group A were also significantly higher than those in Group B (P < 0.01). The Ce(propofol) when bispectral index < or = 40 in Group A, B, C were approximately at 6, 5 and 3 microg mL (-1), respectively.

CONCLUSIONS

At loss of consciousness and regaining of consciousness, the bispectral index values of younger children group are significantly higher than those of adults. At the same stable concentrations of propofol, the bispectral index values are significantly different between children and adults. This study suggests that there is deviation when the adult algorithm of bispectral index monitoring is applied in paediatric patients under intravenous anaesthesia.

Authors+Show Affiliations

Capital Medical University, Beijing Tongren Hospital, Department of Anesthesiology, Beijing, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

18768092

Citation

Liu, J S., et al. "Variation of Bispectral Index Monitoring in Paediatric Patients Undergoing Propofol-remifentanil Anaesthesia." European Journal of Anaesthesiology, vol. 25, no. 10, 2008, pp. 821-5.
Liu JS, Zhang JM, Yue Y. Variation of bispectral index monitoring in paediatric patients undergoing propofol-remifentanil anaesthesia. Eur J Anaesthesiol. 2008;25(10):821-5.
Liu, J. S., Zhang, J. M., & Yue, Y. (2008). Variation of bispectral index monitoring in paediatric patients undergoing propofol-remifentanil anaesthesia. European Journal of Anaesthesiology, 25(10), 821-5. https://doi.org/10.1017/S0265021508004559
Liu JS, Zhang JM, Yue Y. Variation of Bispectral Index Monitoring in Paediatric Patients Undergoing Propofol-remifentanil Anaesthesia. Eur J Anaesthesiol. 2008;25(10):821-5. PubMed PMID: 18768092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variation of bispectral index monitoring in paediatric patients undergoing propofol-remifentanil anaesthesia. AU - Liu,J S, AU - Zhang,J M, AU - Yue,Y, PY - 2008/9/5/pubmed PY - 2008/12/17/medline PY - 2008/9/5/entrez SP - 821 EP - 5 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 25 IS - 10 N2 - BACKGROUND AND OBJECTIVE: The technology of bispectral index monitoring is based on an algorithm developed from adults. This study was conducted to investigate the difference in bispectral index monitoring between paediatric and adult patients under intravenous anaesthesia. METHODS: In all, 68 patients undergoing elective surgery were divided into three groups as follows: Group A (younger children, n = 20, 3 yr < or = yr < or = 5 yr), Group B (older children, n = 20, 6 yr < or = yr < or = 12 yr), Group C (adults, n = 28, 25 yr < or = yr < or = 50 yr). All patients were induced by plasma target-controlled infusion of propofol till loss of consciousness (loss of response to verbal commands and eyelash reflex). The plasma concentration (Cp(propofol)) and effect-site concentration (Ce(propofol)) of propofol and bispectral index values were compared at loss of consciousness and regaining of consciousness. During the operation, remifentanil was infused at a fixed rate of 0.25 microg kg (-1) min (-1), and the minute average bispectral index values of three groups were also compared at different stable concentrations of propofol (Ce(propofol) = Cp(propofol) = 2,3, 4 and 5 microg mL (-1), respectively). RESULTS: At loss of consciousness and regaining of consciousness, the bispectral index values in Group A (loss of consciousness: 74.7 +/- 6.3, regaining of consciousness: 81.1 +/- 10.5) were significantly higher than those in Group C (loss of consciousness: 68.6 +/- 69.4, regaining of consciousness: 74.5 +/- 6.0) (P < 0.01). There was no statistical difference between Cp(propofol) in all groups at loss of consciousness and regaining of consciousness. The Ce(propofol) at loss of consciousness in Group A (3.57 +/- 0.60 microg mL (-1) and B (3.25 +/- 0.44 microg mL(-1)) were significantly higher than those in Group C (2.15 +/- 0.86 microg mL (-1)) (P < 0.01). At the same stable concentrations of propofol, the bispectral index values in Group A and B were significantly higher than those in Group C, and the bispectral index values in Group A were also significantly higher than those in Group B (P < 0.01). The Ce(propofol) when bispectral index < or = 40 in Group A, B, C were approximately at 6, 5 and 3 microg mL (-1), respectively. CONCLUSIONS: At loss of consciousness and regaining of consciousness, the bispectral index values of younger children group are significantly higher than those of adults. At the same stable concentrations of propofol, the bispectral index values are significantly different between children and adults. This study suggests that there is deviation when the adult algorithm of bispectral index monitoring is applied in paediatric patients under intravenous anaesthesia. SN - 1365-2346 UR - https://www.unboundmedicine.com/medline/citation/18768092/Variation_of_bispectral_index_monitoring_in_paediatric_patients_undergoing_propofol_remifentanil_anaesthesia_ L2 - https://doi.org/10.1017/S0265021508004559 DB - PRIME DP - Unbound Medicine ER -