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Potential effects of chondroitin sulfate on joint swelling: a GAIT report.
Osteoarthritis Cartilage 2008; 16 Suppl 3:S22-4OC

Abstract

The Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) was a randomized double-blind placebo and active comparator (celecoxib) controlled trial of 1583 persons with symptomatic osteoarthritis (OA) of the knee(1). Patients randomized to celecoxib had significant improvement in knee pain compared to those randomized to placebo. No statistically significant improvement in knee pain compared to placebo was seen among patients randomized to the dietary supplements, although a subset of patients with moderate-to-severe knee pain at entry who were assigned to the combination of glucosamine and chondroitin sulfate did seem to experience some improvement. Additionally, patients taking chondroitin sulfate were noted to have a statistically significant improvement in knee joint swelling. An exploratory post hoc analysis of GAIT patients suggested the effect of chondroitin sulfate on joint swelling occurred more often in patients with milder pain and lower Kellgren-Lawrence Grade at entry.

Authors+Show Affiliations

University of Maryland School of Medicine, MSTF 8-34, Baltimore, MD 21201, United States. mhochber@umaryland.edu

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18768335

Citation

Hochberg, M C., and D O. Clegg. "Potential Effects of Chondroitin Sulfate On Joint Swelling: a GAIT Report." Osteoarthritis and Cartilage, vol. 16 Suppl 3, 2008, pp. S22-4.
Hochberg MC, Clegg DO. Potential effects of chondroitin sulfate on joint swelling: a GAIT report. Osteoarthr Cartil. 2008;16 Suppl 3:S22-4.
Hochberg, M. C., & Clegg, D. O. (2008). Potential effects of chondroitin sulfate on joint swelling: a GAIT report. Osteoarthritis and Cartilage, 16 Suppl 3, pp. S22-4. doi:10.1016/j.joca.2008.06.024.
Hochberg MC, Clegg DO. Potential Effects of Chondroitin Sulfate On Joint Swelling: a GAIT Report. Osteoarthr Cartil. 2008;16 Suppl 3:S22-4. PubMed PMID: 18768335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential effects of chondroitin sulfate on joint swelling: a GAIT report. AU - Hochberg,M C, AU - Clegg,D O, Y1 - 2008/09/02/ PY - 2008/9/5/pubmed PY - 2008/12/17/medline PY - 2008/9/5/entrez SP - S22 EP - 4 JF - Osteoarthritis and cartilage JO - Osteoarthr. Cartil. VL - 16 Suppl 3 N2 - The Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) was a randomized double-blind placebo and active comparator (celecoxib) controlled trial of 1583 persons with symptomatic osteoarthritis (OA) of the knee(1). Patients randomized to celecoxib had significant improvement in knee pain compared to those randomized to placebo. No statistically significant improvement in knee pain compared to placebo was seen among patients randomized to the dietary supplements, although a subset of patients with moderate-to-severe knee pain at entry who were assigned to the combination of glucosamine and chondroitin sulfate did seem to experience some improvement. Additionally, patients taking chondroitin sulfate were noted to have a statistically significant improvement in knee joint swelling. An exploratory post hoc analysis of GAIT patients suggested the effect of chondroitin sulfate on joint swelling occurred more often in patients with milder pain and lower Kellgren-Lawrence Grade at entry. SN - 1522-9653 UR - https://www.unboundmedicine.com/medline/citation/18768335/Potential_effects_of_chondroitin_sulfate_on_joint_swelling:_a_GAIT_report_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S1063-4584(08)00204-5 DB - PRIME DP - Unbound Medicine ER -