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Age and severity of mucosal lesions influence the performance of serologic markers in Helicobacter pylori-associated gastroduodenal pathologies.
Cancer Epidemiol Biomarkers Prev 2008; 17(9):2498-504CE

Abstract

OBJECTIVE

The course of Helicobacter pylori infection and antibody response to CagA in patients with preneoplastic lesions and gastric cancer has not been thoroughly studied. We aimed to study H. pylori infection and antibody response to CagA in patients with non-atrophic gastritis, preneoplastic lesions, and gastric cancer.

METHODS

We studied patients attending one Oncology Hospital and one General Hospital in Mexico City. Diagnosis was based on endoscopy and histopathology in biopsies from six stomach regions. H. pylori infection was assessed by histology and serology, and antibodies against CagA were measured with immunoassay.

RESULTS

We included 618 patients, 368 with non-atrophic gastritis, 126 with precancerous lesions, and 65 with gastric cancer; in addition, 59 patients with duodenal ulcer were studied. Detection of infection and IgG against CagA had a significant increase from non-atrophic gastritis to mild and up to advanced stages of metaplasia (P < 0.05), followed by decreased infection and IgG to CagA in patients with gastric cancer (P < 0.05). However, infection and CagA antibodies were associated with young gastric cancer cases. Duodenal ulcer showed a significant association with infection detected by histology and serology, particularly among women, and a trend to associate with IgG to CagA.

CONCLUSIONS

This study shows that H. pylori infection and CagA are risk markers for intestinal metaplasia. The prevalence of these risk markers decreases in gastric cancer, probably reflecting that infection decreases after advanced atrophy and metaplasia in the gastric mucosa. State of the disease, age, and sex influence the association of H. pylori infection and IgG response to CagA with gastroduodenal diseases.

Authors+Show Affiliations

Unidad de Investigación en Enfermedades Infecciosas, Hospital de Pediatría, Instituto Mexicano del Seguro Social, Morelos, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18768521

Citation

Camorlinga-Ponce, Margarita, et al. "Age and Severity of Mucosal Lesions Influence the Performance of Serologic Markers in Helicobacter Pylori-associated Gastroduodenal Pathologies." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 9, 2008, pp. 2498-504.
Camorlinga-Ponce M, Flores-Luna L, Lazcano-Ponce E, et al. Age and severity of mucosal lesions influence the performance of serologic markers in Helicobacter pylori-associated gastroduodenal pathologies. Cancer Epidemiol Biomarkers Prev. 2008;17(9):2498-504.
Camorlinga-Ponce, M., Flores-Luna, L., Lazcano-Ponce, E., Herrero, R., Bernal-Sahagún, F., Abdo-Francis, J. M., ... Torres, J. (2008). Age and severity of mucosal lesions influence the performance of serologic markers in Helicobacter pylori-associated gastroduodenal pathologies. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(9), pp. 2498-504. doi:10.1158/1055-9965.EPI-08-0289.
Camorlinga-Ponce M, et al. Age and Severity of Mucosal Lesions Influence the Performance of Serologic Markers in Helicobacter Pylori-associated Gastroduodenal Pathologies. Cancer Epidemiol Biomarkers Prev. 2008;17(9):2498-504. PubMed PMID: 18768521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age and severity of mucosal lesions influence the performance of serologic markers in Helicobacter pylori-associated gastroduodenal pathologies. AU - Camorlinga-Ponce,Margarita, AU - Flores-Luna,Lourdes, AU - Lazcano-Ponce,Eduardo, AU - Herrero,Rolando, AU - Bernal-Sahagún,Fernando, AU - Abdo-Francis,Juan Miguel, AU - Aguirre-García,Jesús, AU - Muñoz,Nubia, AU - Torres,Javier, PY - 2008/9/5/pubmed PY - 2008/10/22/medline PY - 2008/9/5/entrez SP - 2498 EP - 504 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 17 IS - 9 N2 - OBJECTIVE: The course of Helicobacter pylori infection and antibody response to CagA in patients with preneoplastic lesions and gastric cancer has not been thoroughly studied. We aimed to study H. pylori infection and antibody response to CagA in patients with non-atrophic gastritis, preneoplastic lesions, and gastric cancer. METHODS: We studied patients attending one Oncology Hospital and one General Hospital in Mexico City. Diagnosis was based on endoscopy and histopathology in biopsies from six stomach regions. H. pylori infection was assessed by histology and serology, and antibodies against CagA were measured with immunoassay. RESULTS: We included 618 patients, 368 with non-atrophic gastritis, 126 with precancerous lesions, and 65 with gastric cancer; in addition, 59 patients with duodenal ulcer were studied. Detection of infection and IgG against CagA had a significant increase from non-atrophic gastritis to mild and up to advanced stages of metaplasia (P < 0.05), followed by decreased infection and IgG to CagA in patients with gastric cancer (P < 0.05). However, infection and CagA antibodies were associated with young gastric cancer cases. Duodenal ulcer showed a significant association with infection detected by histology and serology, particularly among women, and a trend to associate with IgG to CagA. CONCLUSIONS: This study shows that H. pylori infection and CagA are risk markers for intestinal metaplasia. The prevalence of these risk markers decreases in gastric cancer, probably reflecting that infection decreases after advanced atrophy and metaplasia in the gastric mucosa. State of the disease, age, and sex influence the association of H. pylori infection and IgG response to CagA with gastroduodenal diseases. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/18768521/Age_and_severity_of_mucosal_lesions_influence_the_performance_of_serologic_markers_in_Helicobacter_pylori_associated_gastroduodenal_pathologies_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=18768521 DB - PRIME DP - Unbound Medicine ER -