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Fruit and vegetable consumption and risk of bladder cancer: a prospective cohort study.

Abstract

Fruit and vegetable consumption has been inconsistently associated with risk of bladder cancer. We used data from a prospective population-based cohort study of 82,002 Swedish women and men to examine the association between fruit and vegetable consumption and bladder cancer incidence. Diet was assessed with a validated food frequency questionnaire. During a mean follow-up of 9.4 years, 485 incident cases of bladder cancer were identified in the Swedish cancer registries. We found no statistically significant association between intakes of total fruits and vegetables, total fruits, or total vegetables and bladder cancer risk after adjustment for age, sex, education, and cigarette smoking. The multivariate rate ratios (95% confidence intervals) comparing the highest with the lowest quartile of intake were 0.80 (0.60-1.05) for total fruits and vegetables, 0.93 (0.69-1.25) for fruits, and 0.89 (0.67-1.19) for vegetables. Likewise, no associations were observed for citrus fruits, cruciferous vegetables, or green leafy vegetables. The associations did not differ by sex or smoking status. In conclusion, findings from this prospective study suggest that fruit and vegetable intakes are not likely to be appreciably associated with the risk of bladder cancer.

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  • Authors+Show Affiliations

    ,

    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.se

    , ,

    Source

    MeSH

    Female
    Fruit
    Humans
    Incidence
    Male
    Middle Aged
    Multivariate Analysis
    Prospective Studies
    Registries
    Risk Factors
    Sweden
    Urinary Bladder Neoplasms
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18768526

    Citation

    Larsson, Susanna C., et al. "Fruit and Vegetable Consumption and Risk of Bladder Cancer: a Prospective Cohort Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 9, 2008, pp. 2519-22.
    Larsson SC, Andersson SO, Johansson JE, et al. Fruit and vegetable consumption and risk of bladder cancer: a prospective cohort study. Cancer Epidemiol Biomarkers Prev. 2008;17(9):2519-22.
    Larsson, S. C., Andersson, S. O., Johansson, J. E., & Wolk, A. (2008). Fruit and vegetable consumption and risk of bladder cancer: a prospective cohort study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(9), pp. 2519-22. doi:10.1158/1055-9965.EPI-08-0407.
    Larsson SC, et al. Fruit and Vegetable Consumption and Risk of Bladder Cancer: a Prospective Cohort Study. Cancer Epidemiol Biomarkers Prev. 2008;17(9):2519-22. PubMed PMID: 18768526.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fruit and vegetable consumption and risk of bladder cancer: a prospective cohort study. AU - Larsson,Susanna C, AU - Andersson,Swen-Olof, AU - Johansson,Jan-Erik, AU - Wolk,Alicja, PY - 2008/9/5/pubmed PY - 2008/10/22/medline PY - 2008/9/5/entrez SP - 2519 EP - 22 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 17 IS - 9 N2 - Fruit and vegetable consumption has been inconsistently associated with risk of bladder cancer. We used data from a prospective population-based cohort study of 82,002 Swedish women and men to examine the association between fruit and vegetable consumption and bladder cancer incidence. Diet was assessed with a validated food frequency questionnaire. During a mean follow-up of 9.4 years, 485 incident cases of bladder cancer were identified in the Swedish cancer registries. We found no statistically significant association between intakes of total fruits and vegetables, total fruits, or total vegetables and bladder cancer risk after adjustment for age, sex, education, and cigarette smoking. The multivariate rate ratios (95% confidence intervals) comparing the highest with the lowest quartile of intake were 0.80 (0.60-1.05) for total fruits and vegetables, 0.93 (0.69-1.25) for fruits, and 0.89 (0.67-1.19) for vegetables. Likewise, no associations were observed for citrus fruits, cruciferous vegetables, or green leafy vegetables. The associations did not differ by sex or smoking status. In conclusion, findings from this prospective study suggest that fruit and vegetable intakes are not likely to be appreciably associated with the risk of bladder cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/18768526/Fruit_and_vegetable_consumption_and_risk_of_bladder_cancer:_a_prospective_cohort_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=18768526 DB - PRIME DP - Unbound Medicine ER -