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Research in motion: the enigma of Parkinson's disease pathology spread.
Nat Rev Neurosci. 2008 Oct; 9(10):741-5.NR

Abstract

Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Brundin P
Neuronal Survival Unit, Department of Experimental Medical Science,Wallenberg Neuroscience Center, Lund University, SE-221 84 Lund, Sweden. Patrik.Brundin@med.lu.se
Li JY
No affiliation info available
Holton JL
No affiliation info available
Lindvall O
No affiliation info available
Revesz T
No affiliation info available

MeSH

BrainBrain Tissue TransplantationDisease ProgressionGraft SurvivalHumansLewy BodiesNerve DegenerationOxidative StressParkinson Diseasealpha-Synuclein

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18769444

Citation

Brundin, Patrik, et al. "Research in Motion: the Enigma of Parkinson's Disease Pathology Spread." Nature Reviews. Neuroscience, vol. 9, no. 10, 2008, pp. 741-5.
Brundin P, Li JY, Holton JL, et al. Research in motion: the enigma of Parkinson's disease pathology spread. Nat Rev Neurosci. 2008;9(10):741-5.
Brundin, P., Li, J. Y., Holton, J. L., Lindvall, O., & Revesz, T. (2008). Research in motion: the enigma of Parkinson's disease pathology spread. Nature Reviews. Neuroscience, 9(10), 741-5. https://doi.org/10.1038/nrn2477
Brundin P, et al. Research in Motion: the Enigma of Parkinson's Disease Pathology Spread. Nat Rev Neurosci. 2008;9(10):741-5. PubMed PMID: 18769444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Research in motion: the enigma of Parkinson's disease pathology spread. AU - Brundin,Patrik, AU - Li,Jia-Yi, AU - Holton,Janice L, AU - Lindvall,Olle, AU - Revesz,Tamas, Y1 - 2008/09/04/ PY - 2008/9/5/pubmed PY - 2008/10/17/medline PY - 2008/9/5/entrez SP - 741 EP - 5 JF - Nature reviews. Neuroscience JO - Nat Rev Neurosci VL - 9 IS - 10 N2 - Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease. SN - 1471-0048 UR - https://www.unboundmedicine.com/medline/citation/18769444/Research_in_motion:_the_enigma_of_Parkinson's_disease_pathology_spread_ L2 - https://doi.org/10.1038/nrn2477 DB - PRIME DP - Unbound Medicine ER -