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[Vitamin D receptor gene polymorphisms and risk of hip fracture in Chilean elderly women].
Rev Med Chil. 2008 Apr; 136(4):475-81.RM

Abstract

BACKGROUND

Osteoporotic hip fractures are devastating events in older women. There is a genetic modulation of bone phenotypic parameters including bone density (BMD) and bone fragility fractures. Vitamin D receptor (VDR) gene polymorphisms explain a small part of the genetic influence on BMD, whereas their effect on fractures remains uncertain.

AIM

To examine the contributions of VDR genotypes to the susceptibility to hip fracture in elderly Chilean women.

PATIENTS AND METHODS

We recruited 126 women (67 with fractures and 59 without) from Bio-Bio Region, Chile, aged 65 to 94 years. Genotyping for Bsm-l, Apa-1, Taq-1 and Fok-1 VDR polymorphisms was performed using polymerase chain reaction methods. All hip fractures were confirmed by X-ray.

RESULTS

The allele frequencies were 0.49 for B, 0.57 for A, 0.60 for T and 0.65 for F in the Bsm-l, Apa-1, Taq-1 and Fok-1 polymorphisms respectively. The prevalence of these VDR gene polymorphisms in women with fractures were 16% BB, 69% Bb, 15% bb for Bsm-l; 30% AA, 46% Aa, 14% aa for Apa-1; 17% TT, 34 Tt, 8% tt for Taq-1 and 43%FF, 41% Ff, 16% ff for Fok-1. All VDR genotype frequencies did not differ from Hardy-Weinberg expectations. Allele or genotype frequencies did not differ between women with or without fractures. These results did not change when analysis was adjusted by age weight, height or gynecologic history.

CONCLUSIONS

The genotype frequencies of the VDR polymorphisms are in accordance with the frequencies of other Hispanic and Caucasian populations. Our results suggest that VDR polymorphisms are not associated with the risk of hip fracture in older women of this Region of Southern Chile.

Authors+Show Affiliations

Laboratorio de Medicina Molecular, Dirección de Investigación, Facultad de Medicina, Universidad de Concepción, Santiago, Chile. equevedo@udec.clNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

18769790

Citation

Quevedo L, Iván, et al. "[Vitamin D Receptor Gene Polymorphisms and Risk of Hip Fracture in Chilean Elderly Women]." Revista Medica De Chile, vol. 136, no. 4, 2008, pp. 475-81.
Quevedo L I, Martínez B M, Castillo N M, et al. [Vitamin D receptor gene polymorphisms and risk of hip fracture in Chilean elderly women]. Rev Med Chil. 2008;136(4):475-81.
Quevedo L, I., Martínez B, M., Castillo N, M., & Rivera F, N. (2008). [Vitamin D receptor gene polymorphisms and risk of hip fracture in Chilean elderly women]. Revista Medica De Chile, 136(4), 475-81. https://doi.org//S0034-98872008000400008
Quevedo L I, et al. [Vitamin D Receptor Gene Polymorphisms and Risk of Hip Fracture in Chilean Elderly Women]. Rev Med Chil. 2008;136(4):475-81. PubMed PMID: 18769790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Vitamin D receptor gene polymorphisms and risk of hip fracture in Chilean elderly women]. AU - Quevedo L,Iván, AU - Martínez B,Milka, AU - Castillo N,Marcelo, AU - Rivera F,Nancy, Y1 - 2008/06/16/ PY - 2008/9/5/pubmed PY - 2009/5/5/medline PY - 2008/9/5/entrez SP - 475 EP - 81 JF - Revista medica de Chile JO - Rev Med Chil VL - 136 IS - 4 N2 - BACKGROUND: Osteoporotic hip fractures are devastating events in older women. There is a genetic modulation of bone phenotypic parameters including bone density (BMD) and bone fragility fractures. Vitamin D receptor (VDR) gene polymorphisms explain a small part of the genetic influence on BMD, whereas their effect on fractures remains uncertain. AIM: To examine the contributions of VDR genotypes to the susceptibility to hip fracture in elderly Chilean women. PATIENTS AND METHODS: We recruited 126 women (67 with fractures and 59 without) from Bio-Bio Region, Chile, aged 65 to 94 years. Genotyping for Bsm-l, Apa-1, Taq-1 and Fok-1 VDR polymorphisms was performed using polymerase chain reaction methods. All hip fractures were confirmed by X-ray. RESULTS: The allele frequencies were 0.49 for B, 0.57 for A, 0.60 for T and 0.65 for F in the Bsm-l, Apa-1, Taq-1 and Fok-1 polymorphisms respectively. The prevalence of these VDR gene polymorphisms in women with fractures were 16% BB, 69% Bb, 15% bb for Bsm-l; 30% AA, 46% Aa, 14% aa for Apa-1; 17% TT, 34 Tt, 8% tt for Taq-1 and 43%FF, 41% Ff, 16% ff for Fok-1. All VDR genotype frequencies did not differ from Hardy-Weinberg expectations. Allele or genotype frequencies did not differ between women with or without fractures. These results did not change when analysis was adjusted by age weight, height or gynecologic history. CONCLUSIONS: The genotype frequencies of the VDR polymorphisms are in accordance with the frequencies of other Hispanic and Caucasian populations. Our results suggest that VDR polymorphisms are not associated with the risk of hip fracture in older women of this Region of Southern Chile. SN - 0034-9887 UR - https://www.unboundmedicine.com/medline/citation/18769790/[Vitamin_D_receptor_gene_polymorphisms_and_risk_of_hip_fracture_in_Chilean_elderly_women]_ DB - PRIME DP - Unbound Medicine ER -