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[Individual and population risk in acute myocardial infarction: the Chilean INTERHEART study].
Rev Med Chil. 2008 May; 136(5):555-60.RM

Abstract

BACKGROUND

Acute myocardial infarction (AMI) is the first cause of death in Chile.

AIM

To assess the magnitude of risk of individuals and population associated with AMI risk factors.

MATERIAL AND METHODS

Case control study with incident cases and 2 controls paired by age and gender. History of diabetes, hypertension, smoking, stress, depression, diet, weight, height, hip and waist circumference, apolipoprotein (Apo) Al and B were determined. Odds ratio (OR) and population attributable risk (PAR) were calculated with 95% confidence interval.

RESULTS

Three hundred thirty two cases and 672 controls were included. Mean age was 61.6+/-12 years and 22% were women. The higher individual risk was associated with smoking: OR 3.1 (2.3-4.2), hypertension: 2.9 (2.1-3.9), permanent stress: 2.2 (1,3-2,8), increased apoB/ApoAl ratio: 2.1 (1.4-3.0) and diabetes: 2.0 (1.4-2.9). A protective effect of daily consumption of vegetables and/or fruits with and OR of 0.54 (0.4-0.8), was observed. The highest PAR was due to smoking: 42% (33.2-51.4), increased ApoB/ApoAl ratio: 35.2 (19.0-55.8) and hypertension: 32% (24.5-40.8). These three factors explained 71.3% of the AMI risk in Chile. A moderate effect on PAR was observed for abdominal obesity: 16.6% (2.4-61.2), permanent stress: 12.0% (2.3-44.1) and diabetes: 10.8% (6.1-18.3).

CONCLUSIONS

Known risk factors like dyslipidemia, smoking and hypertension explain most of the AMI cases in Chile. The control of these risk factors should have a major effect on morbidity and mortality due to coronary artery disease in our country.

Authors+Show Affiliations

Centro Investigación, Gestión y Educación para la Salud, Departamento de Medicina Interna, Universidad de La Frontera, Temuco, Chile. flanas@ufro.clNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

18769801

Citation

Lanas, Fernando, et al. "[Individual and Population Risk in Acute Myocardial Infarction: the Chilean INTERHEART Study]." Revista Medica De Chile, vol. 136, no. 5, 2008, pp. 555-60.
Lanas F, Potthoff S, Mercadal E, et al. [Individual and population risk in acute myocardial infarction: the Chilean INTERHEART study]. Rev Med Chil. 2008;136(5):555-60.
Lanas, F., Potthoff, S., Mercadal, E., Santibáñez, C., Lanas, A., & Standen, D. (2008). [Individual and population risk in acute myocardial infarction: the Chilean INTERHEART study]. Revista Medica De Chile, 136(5), 555-60. https://doi.org//S0034-98872008000500002
Lanas F, et al. [Individual and Population Risk in Acute Myocardial Infarction: the Chilean INTERHEART Study]. Rev Med Chil. 2008;136(5):555-60. PubMed PMID: 18769801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Individual and population risk in acute myocardial infarction: the Chilean INTERHEART study]. AU - Lanas,Fernando, AU - Potthoff,Sergio, AU - Mercadal,Enrique, AU - Santibáñez,Claudio, AU - Lanas,Alejandra, AU - Standen,Dina, Y1 - 2008/07/30/ PY - 2008/9/5/pubmed PY - 2009/4/25/medline PY - 2008/9/5/entrez SP - 555 EP - 60 JF - Revista medica de Chile JO - Rev Med Chil VL - 136 IS - 5 N2 - BACKGROUND: Acute myocardial infarction (AMI) is the first cause of death in Chile. AIM: To assess the magnitude of risk of individuals and population associated with AMI risk factors. MATERIAL AND METHODS: Case control study with incident cases and 2 controls paired by age and gender. History of diabetes, hypertension, smoking, stress, depression, diet, weight, height, hip and waist circumference, apolipoprotein (Apo) Al and B were determined. Odds ratio (OR) and population attributable risk (PAR) were calculated with 95% confidence interval. RESULTS: Three hundred thirty two cases and 672 controls were included. Mean age was 61.6+/-12 years and 22% were women. The higher individual risk was associated with smoking: OR 3.1 (2.3-4.2), hypertension: 2.9 (2.1-3.9), permanent stress: 2.2 (1,3-2,8), increased apoB/ApoAl ratio: 2.1 (1.4-3.0) and diabetes: 2.0 (1.4-2.9). A protective effect of daily consumption of vegetables and/or fruits with and OR of 0.54 (0.4-0.8), was observed. The highest PAR was due to smoking: 42% (33.2-51.4), increased ApoB/ApoAl ratio: 35.2 (19.0-55.8) and hypertension: 32% (24.5-40.8). These three factors explained 71.3% of the AMI risk in Chile. A moderate effect on PAR was observed for abdominal obesity: 16.6% (2.4-61.2), permanent stress: 12.0% (2.3-44.1) and diabetes: 10.8% (6.1-18.3). CONCLUSIONS: Known risk factors like dyslipidemia, smoking and hypertension explain most of the AMI cases in Chile. The control of these risk factors should have a major effect on morbidity and mortality due to coronary artery disease in our country. SN - 0034-9887 UR - https://www.unboundmedicine.com/medline/citation/18769801/[Individual_and_population_risk_in_acute_myocardial_infarction:_the_Chilean_INTERHEART_study]_ L2 - http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000500002&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -