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Spiro skeletons: a class of privileged structure for chiral ligand design.
Chem Asian J. 2009 Jan 05; 4(1):32-41.CA

Abstract

This Focus Review highlights the exciting results obtained in the area of asymmetric catalysis using spirobiindane- or spirobifluorene-based chiral ligands. The spiro, mono, and bidentate ligands have been successfully applied in a wide range of transition-metal-catalyzed asymmetric reactions, including hydrogenations, carbon-carbon and carbon-heteroatom coupling reactions, with superior or comparable enantioselectivities to those obtained by using the related ligands bearing other backbones, thus proving that the spiro skeleton is a type of privileged structure for chiral ligand design. It is expected that the spiro concept for chiral ligand design will stimulate the future efforts to understand the features that account for their broad applicability and to apply this understanding to seek new privileged chiral ligands and catalysts.

Authors+Show Affiliations

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China. kding@mail.sioc.ac.cnNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18770872

Citation

Ding, Kuiling, et al. "Spiro Skeletons: a Class of Privileged Structure for Chiral Ligand Design." Chemistry, an Asian Journal, vol. 4, no. 1, 2009, pp. 32-41.
Ding K, Han Z, Wang Z. Spiro skeletons: a class of privileged structure for chiral ligand design. Chem Asian J. 2009;4(1):32-41.
Ding, K., Han, Z., & Wang, Z. (2009). Spiro skeletons: a class of privileged structure for chiral ligand design. Chemistry, an Asian Journal, 4(1), 32-41. https://doi.org/10.1002/asia.200800192
Ding K, Han Z, Wang Z. Spiro Skeletons: a Class of Privileged Structure for Chiral Ligand Design. Chem Asian J. 2009 Jan 5;4(1):32-41. PubMed PMID: 18770872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spiro skeletons: a class of privileged structure for chiral ligand design. AU - Ding,Kuiling, AU - Han,Zhaobin, AU - Wang,Zheng, PY - 2008/9/5/pubmed PY - 2009/2/20/medline PY - 2008/9/5/entrez SP - 32 EP - 41 JF - Chemistry, an Asian journal JO - Chem Asian J VL - 4 IS - 1 N2 - This Focus Review highlights the exciting results obtained in the area of asymmetric catalysis using spirobiindane- or spirobifluorene-based chiral ligands. The spiro, mono, and bidentate ligands have been successfully applied in a wide range of transition-metal-catalyzed asymmetric reactions, including hydrogenations, carbon-carbon and carbon-heteroatom coupling reactions, with superior or comparable enantioselectivities to those obtained by using the related ligands bearing other backbones, thus proving that the spiro skeleton is a type of privileged structure for chiral ligand design. It is expected that the spiro concept for chiral ligand design will stimulate the future efforts to understand the features that account for their broad applicability and to apply this understanding to seek new privileged chiral ligands and catalysts. SN - 1861-471X UR - https://www.unboundmedicine.com/medline/citation/18770872/Spiro_skeletons:_a_class_of_privileged_structure_for_chiral_ligand_design_ L2 - https://doi.org/10.1002/asia.200800192 DB - PRIME DP - Unbound Medicine ER -