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Photodynamic therapy as an adjunct to non-surgical periodontal treatment: a randomized, controlled clinical trial.
J Periodontol. 2008 Sep; 79(9):1638-44.JP

Abstract

BACKGROUND

Recent preclinical and clinical data have suggested a potential benefit of photodynamic therapy (PDT) in the treatment of periodontitis. However, there are very limited data from controlled clinical trials evaluating the effect of PDT in the treatment of periodontitis. The aim of this study was to evaluate the clinical and microbiologic effects of the adjunctive use of PDT to non-surgical periodontal treatment.

METHODS

Twenty-four subjects with chronic periodontitis were randomly treated with scaling and root planing followed by a single episode of PDT (test) or scaling and root planing alone (control). Full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), probing depth (PD), gingival recession, and clinical attachment level (CAL) were measured at baseline and 3 and 6 months after therapy. Primary outcome variables were changes in PD and CAL. Microbiologic evaluation of Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans), Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia (previously T. forsythensis), Treponema denticola, Parvimonas micra (previously Peptostreptococcus micros or Micromonas micros), Fusobacterium nucleatum, Campylobacter rectus, Eubacterium nodatum, Eikenella corrodens, and Capnocytophaga spp. was performed at baseline and 3 and 6 months following therapy by using a commercially available polymerase chain reaction test.

RESULTS

At 3 and 6 months after treatment, there were no statistically significant differences between the groups with regard to CAL, PD, FMPS, or microbiologic changes. At 3 and 6 months, a statistically significantly greater improvement in FMBS was found in the test group.

CONCLUSION

The additional application of a single episode of PDT to scaling and root planing failed to result in an additional improvement in terms of PD reduction and CAL gain, but it resulted in a significantly higher reduction in bleeding scores compared to scaling and root planing alone.

Authors+Show Affiliations

Department of Periodontology, Radboud University Medical Center, Philips van Leydenlaan 25, Nijmegen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18771363

Citation

Christodoulides, Nicos, et al. "Photodynamic Therapy as an Adjunct to Non-surgical Periodontal Treatment: a Randomized, Controlled Clinical Trial." Journal of Periodontology, vol. 79, no. 9, 2008, pp. 1638-44.
Christodoulides N, Nikolidakis D, Chondros P, et al. Photodynamic therapy as an adjunct to non-surgical periodontal treatment: a randomized, controlled clinical trial. J Periodontol. 2008;79(9):1638-44.
Christodoulides, N., Nikolidakis, D., Chondros, P., Becker, J., Schwarz, F., Rössler, R., & Sculean, A. (2008). Photodynamic therapy as an adjunct to non-surgical periodontal treatment: a randomized, controlled clinical trial. Journal of Periodontology, 79(9), 1638-44. https://doi.org/10.1902/jop.2008.070652
Christodoulides N, et al. Photodynamic Therapy as an Adjunct to Non-surgical Periodontal Treatment: a Randomized, Controlled Clinical Trial. J Periodontol. 2008;79(9):1638-44. PubMed PMID: 18771363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photodynamic therapy as an adjunct to non-surgical periodontal treatment: a randomized, controlled clinical trial. AU - Christodoulides,Nicos, AU - Nikolidakis,Dimitris, AU - Chondros,Panagiotis, AU - Becker,Jürgen, AU - Schwarz,Frank, AU - Rössler,Ralf, AU - Sculean,Anton, PY - 2008/9/6/pubmed PY - 2008/11/19/medline PY - 2008/9/6/entrez SP - 1638 EP - 44 JF - Journal of periodontology JO - J Periodontol VL - 79 IS - 9 N2 - BACKGROUND: Recent preclinical and clinical data have suggested a potential benefit of photodynamic therapy (PDT) in the treatment of periodontitis. However, there are very limited data from controlled clinical trials evaluating the effect of PDT in the treatment of periodontitis. The aim of this study was to evaluate the clinical and microbiologic effects of the adjunctive use of PDT to non-surgical periodontal treatment. METHODS: Twenty-four subjects with chronic periodontitis were randomly treated with scaling and root planing followed by a single episode of PDT (test) or scaling and root planing alone (control). Full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), probing depth (PD), gingival recession, and clinical attachment level (CAL) were measured at baseline and 3 and 6 months after therapy. Primary outcome variables were changes in PD and CAL. Microbiologic evaluation of Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans), Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia (previously T. forsythensis), Treponema denticola, Parvimonas micra (previously Peptostreptococcus micros or Micromonas micros), Fusobacterium nucleatum, Campylobacter rectus, Eubacterium nodatum, Eikenella corrodens, and Capnocytophaga spp. was performed at baseline and 3 and 6 months following therapy by using a commercially available polymerase chain reaction test. RESULTS: At 3 and 6 months after treatment, there were no statistically significant differences between the groups with regard to CAL, PD, FMPS, or microbiologic changes. At 3 and 6 months, a statistically significantly greater improvement in FMBS was found in the test group. CONCLUSION: The additional application of a single episode of PDT to scaling and root planing failed to result in an additional improvement in terms of PD reduction and CAL gain, but it resulted in a significantly higher reduction in bleeding scores compared to scaling and root planing alone. SN - 0022-3492 UR - https://www.unboundmedicine.com/medline/citation/18771363/Photodynamic_therapy_as_an_adjunct_to_non_surgical_periodontal_treatment:_a_randomized_controlled_clinical_trial_ L2 - https://doi.org/10.1902/jop.2008.070652 DB - PRIME DP - Unbound Medicine ER -