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Treatment of post-stroke dysphagia with repetitive transcranial magnetic stimulation.
Acta Neurol Scand. 2009 Mar; 119(3):155-61.AN

Abstract

BACKGROUND

Up to one-third of patients experience swallowing problems in the period immediately after a stroke.

OBJECTIVE

To investigate the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) on post-stroke dysphagia.

MATERIALS AND METHODS

Twenty-six patients with post-stroke dysphagia due to monohemispheric stroke were randomly allocated to receive real (n = 14) or sham (n = 12) rTMS of the affected motor cortex. Each patient received a total of 300 rTMS pulses at an intensity of 120% hand motor threshold for five consecutive days. Clinical ratings of dysphagia and motor disability were assessed before and immediately after the last session and then again after 1 and 2 months. The amplitude of the motor-evoked potential (MEP) evoked by single-pulse TMS was also assessed before and at 1 month in 16 of the patients.

RESULTS

There were no significant differences between patients who received real rTMS and the sham group in age, hand grip strength, Barthel Index or degree of dysphagia at the baseline assessment. Real rTMS led to a significantly greater improvement compared with sham in dysphagia and motor disability that was maintained over 2 months of follow-up. This was accompanied by a significant increase in the amplitude of the oesophageal MEP evoked from either the stroke or non-stroke hemisphere.

CONCLUSION

rTMS may be a useful adjunct to conventional therapy for dysphagia after stroke.

Authors+Show Affiliations

Department of Neurology, Assiut University Hospital, Assiut, Egypt. emankhedr99@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18771521

Citation

Khedr, E M., et al. "Treatment of Post-stroke Dysphagia With Repetitive Transcranial Magnetic Stimulation." Acta Neurologica Scandinavica, vol. 119, no. 3, 2009, pp. 155-61.
Khedr EM, Abo-Elfetoh N, Rothwell JC. Treatment of post-stroke dysphagia with repetitive transcranial magnetic stimulation. Acta Neurol Scand. 2009;119(3):155-61.
Khedr, E. M., Abo-Elfetoh, N., & Rothwell, J. C. (2009). Treatment of post-stroke dysphagia with repetitive transcranial magnetic stimulation. Acta Neurologica Scandinavica, 119(3), 155-61. https://doi.org/10.1111/j.1600-0404.2008.01093.x
Khedr EM, Abo-Elfetoh N, Rothwell JC. Treatment of Post-stroke Dysphagia With Repetitive Transcranial Magnetic Stimulation. Acta Neurol Scand. 2009;119(3):155-61. PubMed PMID: 18771521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of post-stroke dysphagia with repetitive transcranial magnetic stimulation. AU - Khedr,E M, AU - Abo-Elfetoh,N, AU - Rothwell,J C, Y1 - 2008/09/03/ PY - 2008/9/6/pubmed PY - 2009/4/15/medline PY - 2008/9/6/entrez SP - 155 EP - 61 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 119 IS - 3 N2 - BACKGROUND: Up to one-third of patients experience swallowing problems in the period immediately after a stroke. OBJECTIVE: To investigate the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) on post-stroke dysphagia. MATERIALS AND METHODS: Twenty-six patients with post-stroke dysphagia due to monohemispheric stroke were randomly allocated to receive real (n = 14) or sham (n = 12) rTMS of the affected motor cortex. Each patient received a total of 300 rTMS pulses at an intensity of 120% hand motor threshold for five consecutive days. Clinical ratings of dysphagia and motor disability were assessed before and immediately after the last session and then again after 1 and 2 months. The amplitude of the motor-evoked potential (MEP) evoked by single-pulse TMS was also assessed before and at 1 month in 16 of the patients. RESULTS: There were no significant differences between patients who received real rTMS and the sham group in age, hand grip strength, Barthel Index or degree of dysphagia at the baseline assessment. Real rTMS led to a significantly greater improvement compared with sham in dysphagia and motor disability that was maintained over 2 months of follow-up. This was accompanied by a significant increase in the amplitude of the oesophageal MEP evoked from either the stroke or non-stroke hemisphere. CONCLUSION: rTMS may be a useful adjunct to conventional therapy for dysphagia after stroke. SN - 1600-0404 UR - https://www.unboundmedicine.com/medline/citation/18771521/Treatment_of_post_stroke_dysphagia_with_repetitive_transcranial_magnetic_stimulation_ L2 - https://doi.org/10.1111/j.1600-0404.2008.01093.x DB - PRIME DP - Unbound Medicine ER -