Tags

Type your tag names separated by a space and hit enter

Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission.
Int J Neuropsychopharmacol 2009; 12(3):357-70IJ

Abstract

In this double-blind, placebo-controlled study, we examined the effects of subanaesthetic doses of ketamine (an NMDA glutamate receptor antagonist) and thiopental (a GABA-A receptor agonist) on the event-related potential (ERP) correlates of deviant stimulus processing in 24 healthy adults. Participants completed three separate pharmacological challenge sessions (ketamine, thiopental, saline) in a counterbalanced order. EEG data were recorded both before and during each challenge while participants performed a visual 'oddball' task consisting of infrequent 'target' and 'novel' stimuli intermixed with frequent 'standard' stimuli. We examined drug effects on the amplitude and latency of the P300 (P3) component of the ERP elicited by target (P3b) and novel stimuli (P3a), as well as the N200 (N2) component elicited by both target and novel stimuli, and the N100 (N1) elicited by standard stimuli. Relative to placebo, both drugs reduced the amplitude of parietal P3b. While both drugs reduced parietal P3a and Novelty N2, ketamine also shortened P3a latency, reduced Novelty N2 amplitude more than thiopental, and increased frontal P3a amplitude relative to placebo. Overall, the data suggest that both the GABA-A and NMDA receptor systems modulate P3b and P3a. NMDA antagonism appears to lead to more varied effects on the neural correlates of novelty processing.

Authors+Show Affiliations

NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. toddw@lclark.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18771605

Citation

Watson, Todd D., et al. "Modulation of the Cortical Processing of Novel and Target Stimuli By Drugs Affecting Glutamate and GABA Neurotransmission." The International Journal of Neuropsychopharmacology, vol. 12, no. 3, 2009, pp. 357-70.
Watson TD, Petrakis IL, Edgecombe J, et al. Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission. Int J Neuropsychopharmacol. 2009;12(3):357-70.
Watson, T. D., Petrakis, I. L., Edgecombe, J., Perrino, A., Krystal, J. H., & Mathalon, D. H. (2009). Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission. The International Journal of Neuropsychopharmacology, 12(3), pp. 357-70. doi:10.1017/S1461145708009334.
Watson TD, et al. Modulation of the Cortical Processing of Novel and Target Stimuli By Drugs Affecting Glutamate and GABA Neurotransmission. Int J Neuropsychopharmacol. 2009;12(3):357-70. PubMed PMID: 18771605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission. AU - Watson,Todd D, AU - Petrakis,Ismene L, AU - Edgecombe,Javon, AU - Perrino,Albert, AU - Krystal,John H, AU - Mathalon,Daniel H, Y1 - 2008/09/04/ PY - 2008/9/6/pubmed PY - 2009/6/9/medline PY - 2008/9/6/entrez SP - 357 EP - 70 JF - The international journal of neuropsychopharmacology JO - Int. J. Neuropsychopharmacol. VL - 12 IS - 3 N2 - In this double-blind, placebo-controlled study, we examined the effects of subanaesthetic doses of ketamine (an NMDA glutamate receptor antagonist) and thiopental (a GABA-A receptor agonist) on the event-related potential (ERP) correlates of deviant stimulus processing in 24 healthy adults. Participants completed three separate pharmacological challenge sessions (ketamine, thiopental, saline) in a counterbalanced order. EEG data were recorded both before and during each challenge while participants performed a visual 'oddball' task consisting of infrequent 'target' and 'novel' stimuli intermixed with frequent 'standard' stimuli. We examined drug effects on the amplitude and latency of the P300 (P3) component of the ERP elicited by target (P3b) and novel stimuli (P3a), as well as the N200 (N2) component elicited by both target and novel stimuli, and the N100 (N1) elicited by standard stimuli. Relative to placebo, both drugs reduced the amplitude of parietal P3b. While both drugs reduced parietal P3a and Novelty N2, ketamine also shortened P3a latency, reduced Novelty N2 amplitude more than thiopental, and increased frontal P3a amplitude relative to placebo. Overall, the data suggest that both the GABA-A and NMDA receptor systems modulate P3b and P3a. NMDA antagonism appears to lead to more varied effects on the neural correlates of novelty processing. SN - 1469-5111 UR - https://www.unboundmedicine.com/medline/citation/18771605/Modulation_of_the_cortical_processing_of_novel_and_target_stimuli_by_drugs_affecting_glutamate_and_GABA_neurotransmission_ L2 - https://academic.oup.com/ijnp/article-lookup/doi/10.1017/S1461145708009334 DB - PRIME DP - Unbound Medicine ER -