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Long-term effects of prenatal stress: changes in adult cardiovascular regulation and sensitivity to stress.
Neurosci Biobehav Rev 2009; 33(2):191-203NB

Abstract

Prenatal environment exerts profound influences on the development of an organism and stressful events during pregnancy can bring about long-term physiological/behavioral alterations in the offspring. Epidemiological evidence points to a relationship between intrauterine growth restriction (IUGR), body weight at birth, and adult cardiovascular disease. Experimental research employed different models of IUGR, including altered maternal nutrition, exposure to elevated glucocorticoids, and reduced placental perfusion, all of which can program, when acting during sensitive temporal windows of foetal life, alterations in cardiovascular regulation and stress sensitivity. Original data are presented indicating that prenatal psychological stress (intermittent restraint) does not induce in the rat adult offspring changes of plasma corticosterone levels, cardiac autonomic modulation, and circadian rhythmicity of heart rate (HR), body temperature (T) and physical activity (Act) at rest. However, prenatally stressed rats--when further stimulated in adulthood--exhibit prolonged adrenocortical stress responsivity, disturbed circadian rhythmicity of HR, T, and Act, and increased adrenal weight. This evidence supports the idea that prenatal stress per se does not change dramatically a given structure or function, but it affects resilience and renders the animal more susceptible to pathophysiological outcomes when further insults occur during adulthood.

Authors+Show Affiliations

Stress Physiology Laboratory, Department of Evolutionary and Functional Biology, University of Parma, Via Usberti 11/a, 43100 Parma, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18771688

Citation

Mastorci, Francesca, et al. "Long-term Effects of Prenatal Stress: Changes in Adult Cardiovascular Regulation and Sensitivity to Stress." Neuroscience and Biobehavioral Reviews, vol. 33, no. 2, 2009, pp. 191-203.
Mastorci F, Vicentini M, Viltart O, et al. Long-term effects of prenatal stress: changes in adult cardiovascular regulation and sensitivity to stress. Neurosci Biobehav Rev. 2009;33(2):191-203.
Mastorci, F., Vicentini, M., Viltart, O., Manghi, M., Graiani, G., Quaini, F., ... Sgoifo, A. (2009). Long-term effects of prenatal stress: changes in adult cardiovascular regulation and sensitivity to stress. Neuroscience and Biobehavioral Reviews, 33(2), pp. 191-203. doi:10.1016/j.neubiorev.2008.08.001.
Mastorci F, et al. Long-term Effects of Prenatal Stress: Changes in Adult Cardiovascular Regulation and Sensitivity to Stress. Neurosci Biobehav Rev. 2009;33(2):191-203. PubMed PMID: 18771688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term effects of prenatal stress: changes in adult cardiovascular regulation and sensitivity to stress. AU - Mastorci,Francesca, AU - Vicentini,Massimo, AU - Viltart,Odile, AU - Manghi,Massimo, AU - Graiani,Gallia, AU - Quaini,Federico, AU - Meerlo,Peter, AU - Nalivaiko,Eugene, AU - Maccari,Stefania, AU - Sgoifo,Andrea, Y1 - 2008/08/13/ PY - 2008/02/21/received PY - 2008/07/21/revised PY - 2008/08/01/accepted PY - 2008/9/6/pubmed PY - 2009/3/26/medline PY - 2008/9/6/entrez SP - 191 EP - 203 JF - Neuroscience and biobehavioral reviews JO - Neurosci Biobehav Rev VL - 33 IS - 2 N2 - Prenatal environment exerts profound influences on the development of an organism and stressful events during pregnancy can bring about long-term physiological/behavioral alterations in the offspring. Epidemiological evidence points to a relationship between intrauterine growth restriction (IUGR), body weight at birth, and adult cardiovascular disease. Experimental research employed different models of IUGR, including altered maternal nutrition, exposure to elevated glucocorticoids, and reduced placental perfusion, all of which can program, when acting during sensitive temporal windows of foetal life, alterations in cardiovascular regulation and stress sensitivity. Original data are presented indicating that prenatal psychological stress (intermittent restraint) does not induce in the rat adult offspring changes of plasma corticosterone levels, cardiac autonomic modulation, and circadian rhythmicity of heart rate (HR), body temperature (T) and physical activity (Act) at rest. However, prenatally stressed rats--when further stimulated in adulthood--exhibit prolonged adrenocortical stress responsivity, disturbed circadian rhythmicity of HR, T, and Act, and increased adrenal weight. This evidence supports the idea that prenatal stress per se does not change dramatically a given structure or function, but it affects resilience and renders the animal more susceptible to pathophysiological outcomes when further insults occur during adulthood. SN - 0149-7634 UR - https://www.unboundmedicine.com/medline/citation/18771688/Long_term_effects_of_prenatal_stress:_changes_in_adult_cardiovascular_regulation_and_sensitivity_to_stress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0149-7634(08)00122-X DB - PRIME DP - Unbound Medicine ER -