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Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias.
Prog Brain Res. 2008; 172:465-78.PB

Abstract

Appearance of dyskinesia is a common problem of long-term Levodopa (L-DOPA) treatment in Parkinson's disease (PD) patients and represents a major limitation for the pharmacological management of the motor symptoms in the advanced stages of disease. An increasing body of evidence points to dopamine released as a false neurotransmitter from the striatal serotonin terminals as the main pre-synaptic determinant of L-DOPA-induced dyskinesia. Here we review the animal experimental and human clinical data in support of this view, which point to the serotonin system as a promising target for anti-dyskinetic therapy in PD patients under L-DOPA medication.

Authors+Show Affiliations

Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden. Manolo.Carta@med.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18772046

Citation

Carta, Manolo, et al. "Serotonin-dopamine Interaction in the Induction and Maintenance of L-DOPA-induced Dyskinesias." Progress in Brain Research, vol. 172, 2008, pp. 465-78.
Carta M, Carlsson T, Muñoz A, et al. Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias. Prog Brain Res. 2008;172:465-78.
Carta, M., Carlsson, T., Muñoz, A., Kirik, D., & Björklund, A. (2008). Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias. Progress in Brain Research, 172, 465-78. https://doi.org/10.1016/S0079-6123(08)00922-9
Carta M, et al. Serotonin-dopamine Interaction in the Induction and Maintenance of L-DOPA-induced Dyskinesias. Prog Brain Res. 2008;172:465-78. PubMed PMID: 18772046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias. AU - Carta,Manolo, AU - Carlsson,Thomas, AU - Muñoz,Ana, AU - Kirik,Deniz, AU - Björklund,Anders, PY - 2008/9/6/pubmed PY - 2009/1/16/medline PY - 2008/9/6/entrez SP - 465 EP - 78 JF - Progress in brain research JO - Prog Brain Res VL - 172 N2 - Appearance of dyskinesia is a common problem of long-term Levodopa (L-DOPA) treatment in Parkinson's disease (PD) patients and represents a major limitation for the pharmacological management of the motor symptoms in the advanced stages of disease. An increasing body of evidence points to dopamine released as a false neurotransmitter from the striatal serotonin terminals as the main pre-synaptic determinant of L-DOPA-induced dyskinesia. Here we review the animal experimental and human clinical data in support of this view, which point to the serotonin system as a promising target for anti-dyskinetic therapy in PD patients under L-DOPA medication. SN - 1875-7855 UR - https://www.unboundmedicine.com/medline/citation/18772046/Serotonin_dopamine_interaction_in_the_induction_and_maintenance_of_L_DOPA_induced_dyskinesias_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0079-6123(08)00922-9 DB - PRIME DP - Unbound Medicine ER -