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Posterior sub-Tenon injection of triamcinolone acetonide as pretreatment for focal laser photocoagulation in diabetic macular edema patients.
Jpn J Ophthalmol 2008 Jul-Aug; 52(4):265-268JJ

Abstract

PURPOSE

To determine whether a posterior sub-Tenon injection of triamcinolone acetonide (TA) before focal photocoagulation is safe and effective in patients with diabetic macular edema.

METHODS

Sixteen eyes of 11 diabetic patients with unresolved diffuse macular edema were treated with a 20-mg sub-Tenon injection of TA 1 to 2 months before focal photocoagulation. Focal photocoagulation was applied only to microaneurysms, and grid laser photocoagulation was not performed. The main outcome measures used were visual acuity (VA), central macular thickness (CMT) determined by optical coherence tomography (OCT), and the fluorescein angiographic appearance of the retina. Patients were followed for at least 6 months.

RESULTS

One month after the sub-Tenon injection of TA, the macular edema was resolved with a significant reduction of the CMT on OCT. VA improved slightly. Subsequent focal photocoagulation of the microaneurysms maintained the significant reduction of CMT for up to 6 months. A significant improvement of VA was observed in 37.5% patients at 6 months, and there was no decrease in VA in any of the patients.

CONCLUSIONS

A 20-mg sub-Tenon TA injection prior to focal laser photocoagulation is a safe and beneficial treatment in patients with diabetic macular edema.

Authors+Show Affiliations

Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan.Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan. ogata@takii.kmu.ac.jp.Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan.Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan.Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan.Department of Ophthalmology, Kansai Medical University, Hirakata, Osaka, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18773263

Citation

Shima, Chieko, et al. "Posterior sub-Tenon Injection of Triamcinolone Acetonide as Pretreatment for Focal Laser Photocoagulation in Diabetic Macular Edema Patients." Japanese Journal of Ophthalmology, vol. 52, no. 4, 2008, pp. 265-268.
Shima C, Ogata N, Minamino K, et al. Posterior sub-Tenon injection of triamcinolone acetonide as pretreatment for focal laser photocoagulation in diabetic macular edema patients. Jpn J Ophthalmol. 2008;52(4):265-268.
Shima, C., Ogata, N., Minamino, K., Yoshikawa, T., Matsuyama, K., & Matsumura, M. (2008). Posterior sub-Tenon injection of triamcinolone acetonide as pretreatment for focal laser photocoagulation in diabetic macular edema patients. Japanese Journal of Ophthalmology, 52(4), pp. 265-268. doi:10.1007/s10384-008-0549-3.
Shima C, et al. Posterior sub-Tenon Injection of Triamcinolone Acetonide as Pretreatment for Focal Laser Photocoagulation in Diabetic Macular Edema Patients. Jpn J Ophthalmol. 2008;52(4):265-268. PubMed PMID: 18773263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Posterior sub-Tenon injection of triamcinolone acetonide as pretreatment for focal laser photocoagulation in diabetic macular edema patients. AU - Shima,Chieko, AU - Ogata,Nahoko, AU - Minamino,Keizo, AU - Yoshikawa,Tadanori, AU - Matsuyama,Kayako, AU - Matsumura,Miyo, Y1 - 2008/09/05/ PY - 2007/09/04/received PY - 2008/02/22/accepted PY - 2008/9/6/pubmed PY - 2009/1/27/medline PY - 2008/9/6/entrez SP - 265 EP - 268 JF - Japanese journal of ophthalmology JO - Jpn. J. Ophthalmol. VL - 52 IS - 4 N2 - PURPOSE: To determine whether a posterior sub-Tenon injection of triamcinolone acetonide (TA) before focal photocoagulation is safe and effective in patients with diabetic macular edema. METHODS: Sixteen eyes of 11 diabetic patients with unresolved diffuse macular edema were treated with a 20-mg sub-Tenon injection of TA 1 to 2 months before focal photocoagulation. Focal photocoagulation was applied only to microaneurysms, and grid laser photocoagulation was not performed. The main outcome measures used were visual acuity (VA), central macular thickness (CMT) determined by optical coherence tomography (OCT), and the fluorescein angiographic appearance of the retina. Patients were followed for at least 6 months. RESULTS: One month after the sub-Tenon injection of TA, the macular edema was resolved with a significant reduction of the CMT on OCT. VA improved slightly. Subsequent focal photocoagulation of the microaneurysms maintained the significant reduction of CMT for up to 6 months. A significant improvement of VA was observed in 37.5% patients at 6 months, and there was no decrease in VA in any of the patients. CONCLUSIONS: A 20-mg sub-Tenon TA injection prior to focal laser photocoagulation is a safe and beneficial treatment in patients with diabetic macular edema. SN - 0021-5155 UR - https://www.unboundmedicine.com/medline/citation/18773263/Posterior_sub_Tenon_injection_of_triamcinolone_acetonide_as_pretreatment_for_focal_laser_photocoagulation_in_diabetic_macular_edema_patients_ L2 - https://dx.doi.org/10.1007/s10384-008-0549-3 DB - PRIME DP - Unbound Medicine ER -