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Asthma symptoms and bronchial reactivity in school children sensitized to food allergens in infancy.

Abstract

Food allergy in infancy usually disappears but is followed primarily by respiratory allergy. We hypothesized that children allergic to common food allergens in infancy are at increased risk of wheezing illness and bronchial hyperresponsiveness during school age. In a case-control study 69 children 7.2 to 13.3 years of age allergic to egg (N = 60) and/or fish (N = 29) in early life (first 3 years) who attended our allergy outpatient clinic were recruited. They received follow-up for 1 year and were evaluated by parental questionnaire, skin prick testing, spirometry, and metacholine bronchial challenge. Another 154 children (70 sensitized to inhaled allergens) recruited selectively from a general population sample with no history of food allergy during their first 3 years served as control subjects. Twenty-three children (38.3%) maintained their sensitization to egg and 19 (65.5%) to fish; the prevalence of sensitization to > or = 1 inhaled allergen(s) increased from 59.4% to 71% during childhood. Current asthma symptoms were reported more frequently in the study group than in either control groups, sensitized to inhaled allergens and non-sensitized. Children of the study group showed a significantly increased frequency of positive response to metacholine bronchial challenge compared to the control group as a whole; the difference was statistically indicative when study groups separately were compared to the sensitized control subjects. Multivariate logistic regression analysis showed that bronchial hyperresponsiveness, as well as reported current asthma symptoms were associated with early wheezing and early sensitization to inhaled allergens but not with atopic dermatitis in infancy or persistence of egg or fish allergy. Children allergic to egg or fish in infancy are at increased risk for wheezing illness and hyperactive airways in school age; asthma and bronchial hyperresponsiveness development is mostly determined by wheezing and senzitization to inhaled allergens in early life regardless of atopic dermatitis in infancy or retention of food allergy.

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  • Authors+Show Affiliations

    ,

    Department of Allergy-Pneumonology, Penteli Children's Hospital, Athens, Greece. kpriftis@otenet.gr

    , , , ,

    Source

    MeSH

    Adolescent
    Asthma
    Bronchial Hyperreactivity
    Bronchial Provocation Tests
    Case-Control Studies
    Child
    Egg Hypersensitivity
    Female
    Food Hypersensitivity
    Humans
    Male
    Methacholine Chloride
    Risk Factors
    Seafood
    Skin Tests
    Spirometry

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    18773332

    Citation

    Priftis, Kostas N., et al. "Asthma Symptoms and Bronchial Reactivity in School Children Sensitized to Food Allergens in Infancy." The Journal of Asthma : Official Journal of the Association for the Care of Asthma, vol. 45, no. 7, 2008, pp. 590-5.
    Priftis KN, Mermiri D, Papadopoulou A, et al. Asthma symptoms and bronchial reactivity in school children sensitized to food allergens in infancy. J Asthma. 2008;45(7):590-5.
    Priftis, K. N., Mermiri, D., Papadopoulou, A., Papadopoulos, M., Fretzayas, A., & Lagona, E. (2008). Asthma symptoms and bronchial reactivity in school children sensitized to food allergens in infancy. The Journal of Asthma : Official Journal of the Association for the Care of Asthma, 45(7), pp. 590-5. doi:10.1080/02770900802032941.
    Priftis KN, et al. Asthma Symptoms and Bronchial Reactivity in School Children Sensitized to Food Allergens in Infancy. J Asthma. 2008;45(7):590-5. PubMed PMID: 18773332.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Asthma symptoms and bronchial reactivity in school children sensitized to food allergens in infancy. AU - Priftis,Kostas N, AU - Mermiri,Despina, AU - Papadopoulou,Athina, AU - Papadopoulos,Marios, AU - Fretzayas,Andrew, AU - Lagona,Evagelia, PY - 2008/9/6/pubmed PY - 2008/10/3/medline PY - 2008/9/6/entrez SP - 590 EP - 5 JF - The Journal of asthma : official journal of the Association for the Care of Asthma JO - J Asthma VL - 45 IS - 7 N2 - Food allergy in infancy usually disappears but is followed primarily by respiratory allergy. We hypothesized that children allergic to common food allergens in infancy are at increased risk of wheezing illness and bronchial hyperresponsiveness during school age. In a case-control study 69 children 7.2 to 13.3 years of age allergic to egg (N = 60) and/or fish (N = 29) in early life (first 3 years) who attended our allergy outpatient clinic were recruited. They received follow-up for 1 year and were evaluated by parental questionnaire, skin prick testing, spirometry, and metacholine bronchial challenge. Another 154 children (70 sensitized to inhaled allergens) recruited selectively from a general population sample with no history of food allergy during their first 3 years served as control subjects. Twenty-three children (38.3%) maintained their sensitization to egg and 19 (65.5%) to fish; the prevalence of sensitization to > or = 1 inhaled allergen(s) increased from 59.4% to 71% during childhood. Current asthma symptoms were reported more frequently in the study group than in either control groups, sensitized to inhaled allergens and non-sensitized. Children of the study group showed a significantly increased frequency of positive response to metacholine bronchial challenge compared to the control group as a whole; the difference was statistically indicative when study groups separately were compared to the sensitized control subjects. Multivariate logistic regression analysis showed that bronchial hyperresponsiveness, as well as reported current asthma symptoms were associated with early wheezing and early sensitization to inhaled allergens but not with atopic dermatitis in infancy or persistence of egg or fish allergy. Children allergic to egg or fish in infancy are at increased risk for wheezing illness and hyperactive airways in school age; asthma and bronchial hyperresponsiveness development is mostly determined by wheezing and senzitization to inhaled allergens in early life regardless of atopic dermatitis in infancy or retention of food allergy. SN - 1532-4303 UR - https://www.unboundmedicine.com/medline/citation/18773332/Asthma_symptoms_and_bronchial_reactivity_in_school_children_sensitized_to_food_allergens_in_infancy_ L2 - http://www.tandfonline.com/doi/full/10.1080/02770900802032941 DB - PRIME DP - Unbound Medicine ER -