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Cigarette smoke-induced changes in guinea-pig airway responsiveness to histamine and citric acid.
Acta Physiol Scand. 1991 May; 142(1):119-25.AP

Abstract

The effect of 50 min cigarette smoke exposure on airway responsiveness to the bronchoconstrictor and tussive effects of histamine and citric acid has been examined in guinea-pigs. Intravenous histamine increased intratracheal pressure (ITP) in anaesthetized guinea-pigs and the dose-response curve was significantly (P less than 0.05) steeper in cigarette smoke- than in air-exposed animals. ED50 values were 11.4 nmol kg-1 (7.4-16.8, 95% confidence interval) and 42.5 nmol kg-1 (28.8-61.4, 95% confidence interval), respectively (P less than 0.05) in smoke- and air-exposed guinea-pigs indicating an enhanced reactivity. However, the sensitivity to intravenous histamine was not changed by the cigarette smoke exposure, and the maximum increase in intratracheal pressure was the same as in control animals (air: 247 +/- 21%, n = 4; smoke: 223 +/- 18%, n = 7). The cigarette smoke-induced hyperresponsiveness to intravenous histamine was not altered by pretreatment with nebulized lidocaine (0.20 M), ipratropium bromide (0.30 mM) or cromoglycate (0.06 M), suggesting that a neural reflex is unlikely to be involved in the development of hyperresponsiveness. Conscious, smoke-exposed guinea-pigs had a significantly (P less than 0.001) reduced responsiveness to citric acid (0.40 M) and cigarette smoke. Both cough and bronchoconstriction were suppressed for about 1 h, but unchanged 24 h after exposure. The hyporesponsiveness to citric acid was inhibited by atropine (1.4 mumol kg-1 i.p.) and may therefore, at least in part, be due to increased airway secretions. The present data demonstrate that inhalation of cigarette smoke may alter guinea-pig airway responsiveness to tussive and bronchoconstrictor stimuli.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

AB Draco, Lund, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1877360

Citation

Karlsson, J A., et al. "Cigarette Smoke-induced Changes in Guinea-pig Airway Responsiveness to Histamine and Citric Acid." Acta Physiologica Scandinavica, vol. 142, no. 1, 1991, pp. 119-25.
Karlsson JA, Zackrisson C, Sjölin C, et al. Cigarette smoke-induced changes in guinea-pig airway responsiveness to histamine and citric acid. Acta Physiol Scand. 1991;142(1):119-25.
Karlsson, J. A., Zackrisson, C., Sjölin, C., & Forsberg, K. (1991). Cigarette smoke-induced changes in guinea-pig airway responsiveness to histamine and citric acid. Acta Physiologica Scandinavica, 142(1), 119-25.
Karlsson JA, et al. Cigarette Smoke-induced Changes in Guinea-pig Airway Responsiveness to Histamine and Citric Acid. Acta Physiol Scand. 1991;142(1):119-25. PubMed PMID: 1877360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoke-induced changes in guinea-pig airway responsiveness to histamine and citric acid. AU - Karlsson,J A, AU - Zackrisson,C, AU - Sjölin,C, AU - Forsberg,K, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 119 EP - 25 JF - Acta physiologica Scandinavica JO - Acta Physiol Scand VL - 142 IS - 1 N2 - The effect of 50 min cigarette smoke exposure on airway responsiveness to the bronchoconstrictor and tussive effects of histamine and citric acid has been examined in guinea-pigs. Intravenous histamine increased intratracheal pressure (ITP) in anaesthetized guinea-pigs and the dose-response curve was significantly (P less than 0.05) steeper in cigarette smoke- than in air-exposed animals. ED50 values were 11.4 nmol kg-1 (7.4-16.8, 95% confidence interval) and 42.5 nmol kg-1 (28.8-61.4, 95% confidence interval), respectively (P less than 0.05) in smoke- and air-exposed guinea-pigs indicating an enhanced reactivity. However, the sensitivity to intravenous histamine was not changed by the cigarette smoke exposure, and the maximum increase in intratracheal pressure was the same as in control animals (air: 247 +/- 21%, n = 4; smoke: 223 +/- 18%, n = 7). The cigarette smoke-induced hyperresponsiveness to intravenous histamine was not altered by pretreatment with nebulized lidocaine (0.20 M), ipratropium bromide (0.30 mM) or cromoglycate (0.06 M), suggesting that a neural reflex is unlikely to be involved in the development of hyperresponsiveness. Conscious, smoke-exposed guinea-pigs had a significantly (P less than 0.001) reduced responsiveness to citric acid (0.40 M) and cigarette smoke. Both cough and bronchoconstriction were suppressed for about 1 h, but unchanged 24 h after exposure. The hyporesponsiveness to citric acid was inhibited by atropine (1.4 mumol kg-1 i.p.) and may therefore, at least in part, be due to increased airway secretions. The present data demonstrate that inhalation of cigarette smoke may alter guinea-pig airway responsiveness to tussive and bronchoconstrictor stimuli.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0001-6772 UR - https://www.unboundmedicine.com/medline/citation/1877360/Cigarette_smoke_induced_changes_in_guinea_pig_airway_responsiveness_to_histamine_and_citric_acid_ L2 - https://doi.org/10.1111/j.1748-1716.1991.tb09136.x DB - PRIME DP - Unbound Medicine ER -