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Korean red ginseng stimulates insulin release from isolated rat pancreatic islets.
J Ethnopharmacol. 2008 Nov 20; 120(2):190-5.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Korean red ginseng (KRG), one of heat-processed Korean ginseng (Panax ginseng C.A. Meyer), has a long history as herbal remedy for antidiabetic effect.

AIM OF THE STUDY

The effect and mechanism of KRG on stimulation of insulin release were investigated in isolated rat pancreatic islets.

MATERIAL AND METHODS

Pancreatic islets isolated from rats were used to evaluate the insulinotropic action of KRG. The effect of Ca on the insulinotropic action of KRG was investigated.

RESULTS

The aqueous ethanolic extract of KRG (AEE-KRG) (0.1-1.0mg/ml) significantly evoked a stimulation of insulin release at 3.3mM glucose compared to the control. Experiments at different glucose concentrations (8.4 and 16.7mM) showed that AEE-KRG significantly stimulated on its own whereas it did not potentiate insulin secretion induced by glucose. The extracellular Ca(2+)-free condition, a L-type Ca(2+) channel blocker and an ATP-sensitive K(+) channel opener significantly inhibited insulin secretion evoked by AEE-KRG.

CONCLUSION

These findings suggest that KRG displays beneficial effects in the treatment of diabetes at least in part via the stimulation of insulin release in a glucose-independent manner.

Authors+Show Affiliations

Food Convergence Technology Division, Korea Food Research Institute, Kyonggi-do, Republic of Korea.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18773949

Citation

Kim, Kyong, and Hye Young Kim. "Korean Red Ginseng Stimulates Insulin Release From Isolated Rat Pancreatic Islets." Journal of Ethnopharmacology, vol. 120, no. 2, 2008, pp. 190-5.
Kim K, Kim HY. Korean red ginseng stimulates insulin release from isolated rat pancreatic islets. J Ethnopharmacol. 2008;120(2):190-5.
Kim, K., & Kim, H. Y. (2008). Korean red ginseng stimulates insulin release from isolated rat pancreatic islets. Journal of Ethnopharmacology, 120(2), 190-5. https://doi.org/10.1016/j.jep.2008.08.006
Kim K, Kim HY. Korean Red Ginseng Stimulates Insulin Release From Isolated Rat Pancreatic Islets. J Ethnopharmacol. 2008 Nov 20;120(2):190-5. PubMed PMID: 18773949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Korean red ginseng stimulates insulin release from isolated rat pancreatic islets. AU - Kim,Kyong, AU - Kim,Hye Young, Y1 - 2008/08/15/ PY - 2007/10/24/received PY - 2008/08/04/revised PY - 2008/08/05/accepted PY - 2008/9/9/pubmed PY - 2009/2/14/medline PY - 2008/9/9/entrez SP - 190 EP - 5 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 120 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Korean red ginseng (KRG), one of heat-processed Korean ginseng (Panax ginseng C.A. Meyer), has a long history as herbal remedy for antidiabetic effect. AIM OF THE STUDY: The effect and mechanism of KRG on stimulation of insulin release were investigated in isolated rat pancreatic islets. MATERIAL AND METHODS: Pancreatic islets isolated from rats were used to evaluate the insulinotropic action of KRG. The effect of Ca on the insulinotropic action of KRG was investigated. RESULTS: The aqueous ethanolic extract of KRG (AEE-KRG) (0.1-1.0mg/ml) significantly evoked a stimulation of insulin release at 3.3mM glucose compared to the control. Experiments at different glucose concentrations (8.4 and 16.7mM) showed that AEE-KRG significantly stimulated on its own whereas it did not potentiate insulin secretion induced by glucose. The extracellular Ca(2+)-free condition, a L-type Ca(2+) channel blocker and an ATP-sensitive K(+) channel opener significantly inhibited insulin secretion evoked by AEE-KRG. CONCLUSION: These findings suggest that KRG displays beneficial effects in the treatment of diabetes at least in part via the stimulation of insulin release in a glucose-independent manner. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18773949/Korean_red_ginseng_stimulates_insulin_release_from_isolated_rat_pancreatic_islets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00446-7 DB - PRIME DP - Unbound Medicine ER -