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Non-cannabinoid constituents from a high potency Cannabis sativa variety.
Phytochemistry 2008; 69(14):2627-33P

Abstract

Six new non-cannabinoid constituents were isolated from a high potency Cannabis sativa L. variety, namely 5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (1), 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), 4,7-dimethoxy-1,2,5-trihydroxyphenanthrene (4), cannflavin C (5) and beta-sitosteryl-3-O-beta-d-glucopyranoside-2'-O-palmitate (6). In addition, five known compounds, alpha-cannabispiranol (7), chrysoeriol (8), 6-prenylapigenin (9), cannflavin A (10) and beta-acetyl cannabispiranol (11) were identified, with 8 and 9 being reported for the first time from cannabis. Some isolates displayed weak to strong antimicrobial, antileishmanial, antimalarial and anti-oxidant activities. Compounds 2-4 were inactive as analgesics.

Authors+Show Affiliations

National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18774146

Citation

Radwan, Mohamed M., et al. "Non-cannabinoid Constituents From a High Potency Cannabis Sativa Variety." Phytochemistry, vol. 69, no. 14, 2008, pp. 2627-33.
Radwan MM, Elsohly MA, Slade D, et al. Non-cannabinoid constituents from a high potency Cannabis sativa variety. Phytochemistry. 2008;69(14):2627-33.
Radwan, M. M., Elsohly, M. A., Slade, D., Ahmed, S. A., Wilson, L., El-Alfy, A. T., ... Ross, S. A. (2008). Non-cannabinoid constituents from a high potency Cannabis sativa variety. Phytochemistry, 69(14), pp. 2627-33. doi:10.1016/j.phytochem.2008.07.010.
Radwan MM, et al. Non-cannabinoid Constituents From a High Potency Cannabis Sativa Variety. Phytochemistry. 2008;69(14):2627-33. PubMed PMID: 18774146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-cannabinoid constituents from a high potency Cannabis sativa variety. AU - Radwan,Mohamed M, AU - Elsohly,Mahmoud A, AU - Slade,Desmond, AU - Ahmed,Safwat A, AU - Wilson,Lisa, AU - El-Alfy,Abir T, AU - Khan,Ikhlas A, AU - Ross,Samir A, Y1 - 2008/09/04/ PY - 2008/05/02/received PY - 2008/06/03/revised PY - 2008/07/22/accepted PY - 2008/9/9/pubmed PY - 2009/1/17/medline PY - 2008/9/9/entrez SP - 2627 EP - 33 JF - Phytochemistry JO - Phytochemistry VL - 69 IS - 14 N2 - Six new non-cannabinoid constituents were isolated from a high potency Cannabis sativa L. variety, namely 5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (1), 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), 4,7-dimethoxy-1,2,5-trihydroxyphenanthrene (4), cannflavin C (5) and beta-sitosteryl-3-O-beta-d-glucopyranoside-2'-O-palmitate (6). In addition, five known compounds, alpha-cannabispiranol (7), chrysoeriol (8), 6-prenylapigenin (9), cannflavin A (10) and beta-acetyl cannabispiranol (11) were identified, with 8 and 9 being reported for the first time from cannabis. Some isolates displayed weak to strong antimicrobial, antileishmanial, antimalarial and anti-oxidant activities. Compounds 2-4 were inactive as analgesics. SN - 0031-9422 UR - https://www.unboundmedicine.com/medline/citation/18774146/abstract/Non_cannabinoid_constituents_from_a_high_potency_Cannabis_sativa_variety_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9422(08)00351-8 DB - PRIME DP - Unbound Medicine ER -