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Type 2 diabetes mellitus and its renal complications in relation to apolipoprotein E gene polymorphism.
Transl Res 2008; 152(3):134-42TR

Abstract

The apolipoprotein E (APOE) epsilon2 allele is reported to be associated with greater risk of renal impairment in type 2 diabetes. Relationships among APOE polymorphisms, renal impairment, and biochemical parameters were explored. A prospective study of 405 consenting Chinese type 2 diabetic patients [mean age +/- standard deviation (SD): 59.2 +/- 10.3 years] without advanced complications at entry was conducted. APOE genotyping and measurement of plasma biomarkers of oxidative stress and antioxidants were performed at entry. HbA1C, plasma glucose, lipids, creatinine, urine albumin/creatinine, and blood pressure were measured at entry and at up to 4 years of follow-up. APOE allelic frequencies were in Hardy-Weinberg equilibrium. Odds ratios of albuminuria at entry and/or during follow-up for different APOE groups were not significantly different. The non-epsilon2 (epsilon3/3, epsilon3/4, epsilon4/4) group had significantly greater plasma ascorbate (51.6 +/- 20.1 mumol/L) than the epsilon2 (epsilon2/2, epsilon2/3) group (44.5 +/- 16.2 mumol/L, P = 0.021), but higher plasma ascorbate levels did not seem to decrease the risk of renal impairment in the non-epsilon2 group. Baseline plasma lipid-standardized alpha-tocopherol levels were least in epsilon2 subjects with persistent albuminuria (3.6 +/- 1.1 mumol/mmol of total cholesterol plus triglycerides, P = 0.008) compared with epsilon2 subjects who had no albuminuria at entry or during follow-up (4.5 +/- 0.8 mumol/mmol of total cholesterol plus triglycerides). The APOE epsilon2 allele does not seem to be associated with increased risk of renal impairment in Chinese type 2 diabetic patients. Plasma lipid-standardized alpha-tocopherol may play a role in determining risk of renal dysfunction in type 2 diabetes.

Authors+Show Affiliations

Department of Health Technology & Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18774543

Citation

Ma, Shuk-Woon, et al. "Type 2 Diabetes Mellitus and Its Renal Complications in Relation to Apolipoprotein E Gene Polymorphism." Translational Research : the Journal of Laboratory and Clinical Medicine, vol. 152, no. 3, 2008, pp. 134-42.
Ma SW, Benzie IF, Yeung VT. Type 2 diabetes mellitus and its renal complications in relation to apolipoprotein E gene polymorphism. Transl Res. 2008;152(3):134-42.
Ma, S. W., Benzie, I. F., & Yeung, V. T. (2008). Type 2 diabetes mellitus and its renal complications in relation to apolipoprotein E gene polymorphism. Translational Research : the Journal of Laboratory and Clinical Medicine, 152(3), pp. 134-42. doi:10.1016/j.trsl.2008.07.003.
Ma SW, Benzie IF, Yeung VT. Type 2 Diabetes Mellitus and Its Renal Complications in Relation to Apolipoprotein E Gene Polymorphism. Transl Res. 2008;152(3):134-42. PubMed PMID: 18774543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Type 2 diabetes mellitus and its renal complications in relation to apolipoprotein E gene polymorphism. AU - Ma,Shuk-Woon, AU - Benzie,Iris F F, AU - Yeung,Vincent T F, Y1 - 2008/08/12/ PY - 2008/05/23/received PY - 2008/06/11/revised PY - 2008/06/11/accepted PY - 2008/9/9/pubmed PY - 2009/12/16/medline PY - 2008/9/9/entrez SP - 134 EP - 42 JF - Translational research : the journal of laboratory and clinical medicine JO - Transl Res VL - 152 IS - 3 N2 - The apolipoprotein E (APOE) epsilon2 allele is reported to be associated with greater risk of renal impairment in type 2 diabetes. Relationships among APOE polymorphisms, renal impairment, and biochemical parameters were explored. A prospective study of 405 consenting Chinese type 2 diabetic patients [mean age +/- standard deviation (SD): 59.2 +/- 10.3 years] without advanced complications at entry was conducted. APOE genotyping and measurement of plasma biomarkers of oxidative stress and antioxidants were performed at entry. HbA1C, plasma glucose, lipids, creatinine, urine albumin/creatinine, and blood pressure were measured at entry and at up to 4 years of follow-up. APOE allelic frequencies were in Hardy-Weinberg equilibrium. Odds ratios of albuminuria at entry and/or during follow-up for different APOE groups were not significantly different. The non-epsilon2 (epsilon3/3, epsilon3/4, epsilon4/4) group had significantly greater plasma ascorbate (51.6 +/- 20.1 mumol/L) than the epsilon2 (epsilon2/2, epsilon2/3) group (44.5 +/- 16.2 mumol/L, P = 0.021), but higher plasma ascorbate levels did not seem to decrease the risk of renal impairment in the non-epsilon2 group. Baseline plasma lipid-standardized alpha-tocopherol levels were least in epsilon2 subjects with persistent albuminuria (3.6 +/- 1.1 mumol/mmol of total cholesterol plus triglycerides, P = 0.008) compared with epsilon2 subjects who had no albuminuria at entry or during follow-up (4.5 +/- 0.8 mumol/mmol of total cholesterol plus triglycerides). The APOE epsilon2 allele does not seem to be associated with increased risk of renal impairment in Chinese type 2 diabetic patients. Plasma lipid-standardized alpha-tocopherol may play a role in determining risk of renal dysfunction in type 2 diabetes. SN - 1931-5244 UR - https://www.unboundmedicine.com/medline/citation/18774543/Type_2_diabetes_mellitus_and_its_renal_complications_in_relation_to_apolipoprotein_E_gene_polymorphism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1931-5244(08)00188-6 DB - PRIME DP - Unbound Medicine ER -