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Efficiency and pregnancy outcome of serial intrauterine device-guided hysteroscopic adhesiolysis of intrauterine synechiae.
Fertil Steril. 2008 Nov; 90(5):1973-7.FS

Abstract

OBJECTIVE

To highlight the efficiency of intrauterine device (IUD) guidance during hysteroscopic adhesiolysis for severe intrauterine adhesions.

DESIGN

A prospective, randomized trial.

SETTING

Private tertiary and referral infertility clinic.

PATIENT(S)

Seventy-one subfertile patients who underwent hysteroscopic treatment of intrauterine synechiae or adhesions.

INTERVENTION(S)

Thirty-six women in group 1 were initially examined by laparoscopy-hysteroscopy at first look, and an IUD was inserted during hysteroscopic adhesiolysis. The adhesions were further lysed by the guidance of IUD during the second-look office hysteroscopy, 1 week later. Patients were prescribed 2 months of estrogen as well as P therapy, and the IUD was removed by the end of this period. The uterine cavity was evaluated, and adhesions were further lysed by a third-look office hysteroscopy, 1 week after the removal of IUD. Thirty-five women in group 2 were similarly examined by first-look office hysteroscopy, and an IUD was inserted during hysteroscopic adhesiolysis. These patients did not undergo early intervention of office hysteroscopy, 1 week after the first procedure. They also used 2 months of estrogen and P therapy. The IUD was removed by the end of this period, and the uterine cavity was evaluated and adhesions were further lysed during a second-look office hysteroscopy.

MAIN OUTCOME MEASURE(S)

Pregnancy rate and live birth rate.

RESULT(S)

Spontaneous pregnancy rates after treatment were 17/36 (47.2%) and 11/35 (30%), and live birth rates were 10/36 (28%) and 7/35 (20%) in groups 1 and 2, respectively. These differences between the two groups were not statistically significant.

CONCLUSION(S)

The method described especially for early intervention may prevent complications during the treatment of severe intrauterine adhesions and may present a secure and effective alternative for constructive clinical outcomes.

Authors+Show Affiliations

Centrum Clinic, Ankara, Turkey. rpabuccu@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18774563

Citation

Pabuccu, Recai, et al. "Efficiency and Pregnancy Outcome of Serial Intrauterine Device-guided Hysteroscopic Adhesiolysis of Intrauterine Synechiae." Fertility and Sterility, vol. 90, no. 5, 2008, pp. 1973-7.
Pabuccu R, Onalan G, Kaya C, et al. Efficiency and pregnancy outcome of serial intrauterine device-guided hysteroscopic adhesiolysis of intrauterine synechiae. Fertil Steril. 2008;90(5):1973-7.
Pabuccu, R., Onalan, G., Kaya, C., Selam, B., Ceyhan, T., Ornek, T., & Kuzudisli, E. (2008). Efficiency and pregnancy outcome of serial intrauterine device-guided hysteroscopic adhesiolysis of intrauterine synechiae. Fertility and Sterility, 90(5), 1973-7. https://doi.org/10.1016/j.fertnstert.2007.06.074
Pabuccu R, et al. Efficiency and Pregnancy Outcome of Serial Intrauterine Device-guided Hysteroscopic Adhesiolysis of Intrauterine Synechiae. Fertil Steril. 2008;90(5):1973-7. PubMed PMID: 18774563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficiency and pregnancy outcome of serial intrauterine device-guided hysteroscopic adhesiolysis of intrauterine synechiae. AU - Pabuccu,Recai, AU - Onalan,Gogsen, AU - Kaya,Cemil, AU - Selam,Belgin, AU - Ceyhan,Temel, AU - Ornek,Turkan, AU - Kuzudisli,Ebru, Y1 - 2008/09/06/ PY - 2007/02/02/received PY - 2007/06/21/revised PY - 2007/06/21/accepted PY - 2008/9/9/pubmed PY - 2008/12/17/medline PY - 2008/9/9/entrez SP - 1973 EP - 7 JF - Fertility and sterility JO - Fertil. Steril. VL - 90 IS - 5 N2 - OBJECTIVE: To highlight the efficiency of intrauterine device (IUD) guidance during hysteroscopic adhesiolysis for severe intrauterine adhesions. DESIGN: A prospective, randomized trial. SETTING: Private tertiary and referral infertility clinic. PATIENT(S): Seventy-one subfertile patients who underwent hysteroscopic treatment of intrauterine synechiae or adhesions. INTERVENTION(S): Thirty-six women in group 1 were initially examined by laparoscopy-hysteroscopy at first look, and an IUD was inserted during hysteroscopic adhesiolysis. The adhesions were further lysed by the guidance of IUD during the second-look office hysteroscopy, 1 week later. Patients were prescribed 2 months of estrogen as well as P therapy, and the IUD was removed by the end of this period. The uterine cavity was evaluated, and adhesions were further lysed by a third-look office hysteroscopy, 1 week after the removal of IUD. Thirty-five women in group 2 were similarly examined by first-look office hysteroscopy, and an IUD was inserted during hysteroscopic adhesiolysis. These patients did not undergo early intervention of office hysteroscopy, 1 week after the first procedure. They also used 2 months of estrogen and P therapy. The IUD was removed by the end of this period, and the uterine cavity was evaluated and adhesions were further lysed during a second-look office hysteroscopy. MAIN OUTCOME MEASURE(S): Pregnancy rate and live birth rate. RESULT(S): Spontaneous pregnancy rates after treatment were 17/36 (47.2%) and 11/35 (30%), and live birth rates were 10/36 (28%) and 7/35 (20%) in groups 1 and 2, respectively. These differences between the two groups were not statistically significant. CONCLUSION(S): The method described especially for early intervention may prevent complications during the treatment of severe intrauterine adhesions and may present a secure and effective alternative for constructive clinical outcomes. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18774563/Efficiency_and_pregnancy_outcome_of_serial_intrauterine_device_guided_hysteroscopic_adhesiolysis_of_intrauterine_synechiae_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)01426-4 DB - PRIME DP - Unbound Medicine ER -