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Benefits of fish oil supplementation in hyperlipidemia: a systematic review and meta-analysis.
Int J Cardiol. 2009 Jul 24; 136(1):4-16.IJ

Abstract

BACKGROUND

Fish oils have been widely reported as a useful supplement to reduce fasting blood triglyceride levels in individuals with hyperlipidemia. We performed an updated meta-analysis to quantitatively evaluate all the randomized trials of fish oils in hyperlipidemic subjects.

METHODS

We conducted a systematic literature search using several electronic databases supplemented by manual searches of published reference lists, review articles and conference abstracts. We included all placebo-controlled randomized trials of parallel design that evaluated any of the main blood lipid outcomes: total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol or triglycerides (TG). Data were pooled using DerSimonian-Laird's random effects model.

RESULTS

The final analysis comprised of 47 studies in otherwise untreated subjects showed that taking fish oils (weighted average daily intake of 3.25 g of EPA and/or DHA) produced a clinically significant reduction of TG (-0.34 mmol/L, 95% CI: -0.41 to -0.27), no change in total cholesterol (-0.01 mmol/L, 95% CI: -0.03 to 0.01) and very slight increases in HDL (0.01 mmol/L, 95% CI: 0.00 to 0.02) and LDL cholesterol (0.06 mmol/L, 95% CI: 0.03 to 0.09). The reduction of TG correlated with both EPA+DHA intake and initial TG level.

CONCLUSION

Fish oil supplementation produces a clinically significant dose-dependent reduction of fasting blood TG but not total, HDL or LDL cholesterol in hyperlipidemic subjects.

Authors+Show Affiliations

Centre for Complementary Medicine Research, University of Western Sydney, Sydney, New South Wales, Australia. eslickg@med.usyd.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

18774613

Citation

Eslick, Guy D., et al. "Benefits of Fish Oil Supplementation in Hyperlipidemia: a Systematic Review and Meta-analysis." International Journal of Cardiology, vol. 136, no. 1, 2009, pp. 4-16.
Eslick GD, Howe PR, Smith C, et al. Benefits of fish oil supplementation in hyperlipidemia: a systematic review and meta-analysis. Int J Cardiol. 2009;136(1):4-16.
Eslick, G. D., Howe, P. R., Smith, C., Priest, R., & Bensoussan, A. (2009). Benefits of fish oil supplementation in hyperlipidemia: a systematic review and meta-analysis. International Journal of Cardiology, 136(1), 4-16. https://doi.org/10.1016/j.ijcard.2008.03.092
Eslick GD, et al. Benefits of Fish Oil Supplementation in Hyperlipidemia: a Systematic Review and Meta-analysis. Int J Cardiol. 2009 Jul 24;136(1):4-16. PubMed PMID: 18774613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benefits of fish oil supplementation in hyperlipidemia: a systematic review and meta-analysis. AU - Eslick,Guy D, AU - Howe,Peter R C, AU - Smith,Caroline, AU - Priest,Ros, AU - Bensoussan,Alan, Y1 - 2008/09/06/ PY - 2007/11/14/received PY - 2008/03/24/revised PY - 2008/03/29/accepted PY - 2008/9/9/pubmed PY - 2010/3/24/medline PY - 2008/9/9/entrez SP - 4 EP - 16 JF - International journal of cardiology JO - Int J Cardiol VL - 136 IS - 1 N2 - BACKGROUND: Fish oils have been widely reported as a useful supplement to reduce fasting blood triglyceride levels in individuals with hyperlipidemia. We performed an updated meta-analysis to quantitatively evaluate all the randomized trials of fish oils in hyperlipidemic subjects. METHODS: We conducted a systematic literature search using several electronic databases supplemented by manual searches of published reference lists, review articles and conference abstracts. We included all placebo-controlled randomized trials of parallel design that evaluated any of the main blood lipid outcomes: total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol or triglycerides (TG). Data were pooled using DerSimonian-Laird's random effects model. RESULTS: The final analysis comprised of 47 studies in otherwise untreated subjects showed that taking fish oils (weighted average daily intake of 3.25 g of EPA and/or DHA) produced a clinically significant reduction of TG (-0.34 mmol/L, 95% CI: -0.41 to -0.27), no change in total cholesterol (-0.01 mmol/L, 95% CI: -0.03 to 0.01) and very slight increases in HDL (0.01 mmol/L, 95% CI: 0.00 to 0.02) and LDL cholesterol (0.06 mmol/L, 95% CI: 0.03 to 0.09). The reduction of TG correlated with both EPA+DHA intake and initial TG level. CONCLUSION: Fish oil supplementation produces a clinically significant dose-dependent reduction of fasting blood TG but not total, HDL or LDL cholesterol in hyperlipidemic subjects. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/18774613/Benefits_of_fish_oil_supplementation_in_hyperlipidemia:_a_systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(08)00524-X DB - PRIME DP - Unbound Medicine ER -