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Probiotics in functional gastrointestinal disorders: what are the facts?
Curr Opin Pharmacol. 2008 Dec; 8(6):704-8.CO

Abstract

While a rationale for the use of probiotics can be developed for a number of functional gastrointestinal symptoms and syndromes and an experimental basis for their use continues to emerge, the only functional disorder for which an adequate database of clinical trials of probiotics to permit an assessment of clinical efficacy exists is the irritable bowel syndrome (IBS). IBS has also attracted attention, in this regard, because of recent revelations with regard to the potential roles of the enteric flora and immune activation in the pathogenesis of IBS, thereby, leading to a re-awakening of interest in bacteriotherapy in this common and challenging disorder. Some recent randomized controlled studies attest to the efficacy of some probiotics in alleviating individual IBS symptoms while selected strains have a more global impact. Evidence for long-term efficacy is also beginning to emerge though more studies are needed in this regard. Several other issues complicate the interpretation of much of the literature in this area: lack of quality control, use of many different species, and, strains and, above all, significant deficiencies in trial methodology.

Authors+Show Affiliations

Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. e.quigley@ucc.ie

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18775516

Citation

Quigley, Eamonn M M.. "Probiotics in Functional Gastrointestinal Disorders: what Are the Facts?" Current Opinion in Pharmacology, vol. 8, no. 6, 2008, pp. 704-8.
Quigley EM. Probiotics in functional gastrointestinal disorders: what are the facts? Curr Opin Pharmacol. 2008;8(6):704-8.
Quigley, E. M. (2008). Probiotics in functional gastrointestinal disorders: what are the facts? Current Opinion in Pharmacology, 8(6), 704-8. https://doi.org/10.1016/j.coph.2008.08.007
Quigley EM. Probiotics in Functional Gastrointestinal Disorders: what Are the Facts. Curr Opin Pharmacol. 2008;8(6):704-8. PubMed PMID: 18775516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotics in functional gastrointestinal disorders: what are the facts? A1 - Quigley,Eamonn M M, Y1 - 2008/09/15/ PY - 2008/07/15/received PY - 2008/07/19/revised PY - 2008/08/11/accepted PY - 2008/9/9/pubmed PY - 2009/3/20/medline PY - 2008/9/9/entrez SP - 704 EP - 8 JF - Current opinion in pharmacology JO - Curr Opin Pharmacol VL - 8 IS - 6 N2 - While a rationale for the use of probiotics can be developed for a number of functional gastrointestinal symptoms and syndromes and an experimental basis for their use continues to emerge, the only functional disorder for which an adequate database of clinical trials of probiotics to permit an assessment of clinical efficacy exists is the irritable bowel syndrome (IBS). IBS has also attracted attention, in this regard, because of recent revelations with regard to the potential roles of the enteric flora and immune activation in the pathogenesis of IBS, thereby, leading to a re-awakening of interest in bacteriotherapy in this common and challenging disorder. Some recent randomized controlled studies attest to the efficacy of some probiotics in alleviating individual IBS symptoms while selected strains have a more global impact. Evidence for long-term efficacy is also beginning to emerge though more studies are needed in this regard. Several other issues complicate the interpretation of much of the literature in this area: lack of quality control, use of many different species, and, strains and, above all, significant deficiencies in trial methodology. SN - 1471-4892 UR - https://www.unboundmedicine.com/medline/citation/18775516/Probiotics_in_functional_gastrointestinal_disorders:_what_are_the_facts L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4892(08)00127-6 DB - PRIME DP - Unbound Medicine ER -