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Endocannabinoid signaling as a synaptic circuit breaker in neurological disease.

Abstract

Cannabis sativa is one of the oldest herbal plants in the history of medicine. It was used in various therapeutic applications from pain to epilepsy, but its psychotropic effect has reduced its usage in recent medical practice. However, renewed interest has been fueled by major discoveries revealing that cannabis-derived compounds act through a signaling pathway in the human body. Here we review recent advances showing that endocannabinoid signaling is a key regulator of synaptic communication throughout the central nervous system. Its underlying molecular architecture is highly conserved in synapses from the spinal cord to the neocortex, and as a negative feed-back signal, it provides protection against excess presynaptic activity. The endocannabinoid signaling machinery operates on demand in a synapse-specific manner; therefore, its modulation offers new therapeutic opportunities for the selective control of deleterious neuronal activity in several neurological disorders.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, H-1083 Budapest, Hungary. katona@koki.hu

    Source

    Nature medicine 14:9 2008 Sep pg 923-30

    MeSH

    Cannabinoid Receptor Modulators
    Cannabis
    Central Nervous System
    Endocannabinoids
    Humans
    Nervous System Diseases
    Signal Transduction
    Synaptic Transmission

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    18776886

    Citation

    Katona, István, and Tamás F. Freund. "Endocannabinoid Signaling as a Synaptic Circuit Breaker in Neurological Disease." Nature Medicine, vol. 14, no. 9, 2008, pp. 923-30.
    Katona I, Freund TF. Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. Nat Med. 2008;14(9):923-30.
    Katona, I., & Freund, T. F. (2008). Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. Nature Medicine, 14(9), pp. 923-30. doi:10.1038/nm.f.1869.
    Katona I, Freund TF. Endocannabinoid Signaling as a Synaptic Circuit Breaker in Neurological Disease. Nat Med. 2008;14(9):923-30. PubMed PMID: 18776886.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. AU - Katona,István, AU - Freund,Tamás F, Y1 - 2008/09/05/ PY - 2008/9/9/pubmed PY - 2008/10/28/medline PY - 2008/9/9/entrez SP - 923 EP - 30 JF - Nature medicine JO - Nat. Med. VL - 14 IS - 9 N2 - Cannabis sativa is one of the oldest herbal plants in the history of medicine. It was used in various therapeutic applications from pain to epilepsy, but its psychotropic effect has reduced its usage in recent medical practice. However, renewed interest has been fueled by major discoveries revealing that cannabis-derived compounds act through a signaling pathway in the human body. Here we review recent advances showing that endocannabinoid signaling is a key regulator of synaptic communication throughout the central nervous system. Its underlying molecular architecture is highly conserved in synapses from the spinal cord to the neocortex, and as a negative feed-back signal, it provides protection against excess presynaptic activity. The endocannabinoid signaling machinery operates on demand in a synapse-specific manner; therefore, its modulation offers new therapeutic opportunities for the selective control of deleterious neuronal activity in several neurological disorders. SN - 1546-170X UR - https://www.unboundmedicine.com/medline/citation/18776886/Endocannabinoid_signaling_as_a_synaptic_circuit_breaker_in_neurological_disease_ L2 - http://dx.doi.org/10.1038/nm.f.1869 DB - PRIME DP - Unbound Medicine ER -