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Endocannabinoid signaling as a synaptic circuit breaker in neurological disease.
Nat Med 2008; 14(9):923-30NMed

Abstract

Cannabis sativa is one of the oldest herbal plants in the history of medicine. It was used in various therapeutic applications from pain to epilepsy, but its psychotropic effect has reduced its usage in recent medical practice. However, renewed interest has been fueled by major discoveries revealing that cannabis-derived compounds act through a signaling pathway in the human body. Here we review recent advances showing that endocannabinoid signaling is a key regulator of synaptic communication throughout the central nervous system. Its underlying molecular architecture is highly conserved in synapses from the spinal cord to the neocortex, and as a negative feed-back signal, it provides protection against excess presynaptic activity. The endocannabinoid signaling machinery operates on demand in a synapse-specific manner; therefore, its modulation offers new therapeutic opportunities for the selective control of deleterious neuronal activity in several neurological disorders.

Authors+Show Affiliations

Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, H-1083 Budapest, Hungary. katona@koki.huNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18776886

Citation

Katona, István, and Tamás F. Freund. "Endocannabinoid Signaling as a Synaptic Circuit Breaker in Neurological Disease." Nature Medicine, vol. 14, no. 9, 2008, pp. 923-30.
Katona I, Freund TF. Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. Nat Med. 2008;14(9):923-30.
Katona, I., & Freund, T. F. (2008). Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. Nature Medicine, 14(9), pp. 923-30. doi:10.1038/nm.f.1869.
Katona I, Freund TF. Endocannabinoid Signaling as a Synaptic Circuit Breaker in Neurological Disease. Nat Med. 2008;14(9):923-30. PubMed PMID: 18776886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. AU - Katona,István, AU - Freund,Tamás F, Y1 - 2008/09/05/ PY - 2008/9/9/pubmed PY - 2008/10/28/medline PY - 2008/9/9/entrez SP - 923 EP - 30 JF - Nature medicine JO - Nat. Med. VL - 14 IS - 9 N2 - Cannabis sativa is one of the oldest herbal plants in the history of medicine. It was used in various therapeutic applications from pain to epilepsy, but its psychotropic effect has reduced its usage in recent medical practice. However, renewed interest has been fueled by major discoveries revealing that cannabis-derived compounds act through a signaling pathway in the human body. Here we review recent advances showing that endocannabinoid signaling is a key regulator of synaptic communication throughout the central nervous system. Its underlying molecular architecture is highly conserved in synapses from the spinal cord to the neocortex, and as a negative feed-back signal, it provides protection against excess presynaptic activity. The endocannabinoid signaling machinery operates on demand in a synapse-specific manner; therefore, its modulation offers new therapeutic opportunities for the selective control of deleterious neuronal activity in several neurological disorders. SN - 1546-170X UR - https://www.unboundmedicine.com/medline/citation/18776886/Endocannabinoid_signaling_as_a_synaptic_circuit_breaker_in_neurological_disease_ L2 - http://dx.doi.org/10.1038/nm.f.1869 DB - PRIME DP - Unbound Medicine ER -