Tags

Type your tag names separated by a space and hit enter

Dietary isoflavone intake and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.
Breast Cancer Res Treat. 2009 Jul; 116(2):401-11.BC

Abstract

Although epidemiologic studies have shown an inverse association between isoflavones and breast cancer risk, little evidence for a dose-response relation is available. We conducted hospital-based case-control studies of patients aged 20-74 years with primary, incident, histologically confirmed invasive breast cancer, and matched controls from medical checkup examinees in Nagano, Japan and from cancer-free patients in São Paulo, Brazil. A total of 850 pairs (390 Japanese, 81 Japanese Brazilians and 379 non-Japanese Brazilians) completed validated food frequency questionnaires. The odds ratio of breast cancer according to isoflavone intake was estimated using a conditional logistic regression model. We found a statistically significant inverse association between isoflavone intake and the risk of breast cancer for Japanese Brazilians and non-Japanese Brazilians. For Japanese, a non-significant inverse association was limited to postmenopausal women. In the three populations combined, breast cancer risk linearly decreased from 'no' to 'moderate' isoflavone intake and thereafter leveled off. Compared to non-consumers, adjusted odds ratios (95% confidence interval) for consumers in increasing quintile intake categories (median intake in each category: 8.7, 23.1, 33.8, 45.7, and 71.3 mg/day) were 0.69 (0.44-1.09), 0.54 (0.31-0.94), 0.45 (0.26-0.77), 0.34 (0.19-0.62), and 0.43 (0.24-0.76), respectively. Overall, we found an inverse association between dietary isoflavone intake and risk of breast cancer. Our finding suggests a risk-reducing rather than risk-enhancing effect of isoflavones on breast cancer within the range achievable from dietary intake alone. In addition, women may benefit from risk reduction if they consume at least moderate amounts of isoflavones.

Authors+Show Affiliations

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan. moiwasak@ncc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18777206

Citation

Iwasaki, Motoki, et al. "Dietary Isoflavone Intake and Breast Cancer Risk in Case-control Studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians." Breast Cancer Research and Treatment, vol. 116, no. 2, 2009, pp. 401-11.
Iwasaki M, Hamada GS, Nishimoto IN, et al. Dietary isoflavone intake and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Breast Cancer Res Treat. 2009;116(2):401-11.
Iwasaki, M., Hamada, G. S., Nishimoto, I. N., Netto, M. M., Motola, J., Laginha, F. M., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R., Kobayashi, M., Ishihara, J., Yamamoto, S., Hanaoka, T., & Tsugane, S. (2009). Dietary isoflavone intake and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Breast Cancer Research and Treatment, 116(2), 401-11. https://doi.org/10.1007/s10549-008-0168-1
Iwasaki M, et al. Dietary Isoflavone Intake and Breast Cancer Risk in Case-control Studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Breast Cancer Res Treat. 2009;116(2):401-11. PubMed PMID: 18777206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary isoflavone intake and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. AU - Iwasaki,Motoki, AU - Hamada,Gerson Shigeaki, AU - Nishimoto,Ines Nobuko, AU - Netto,Mario Mourão, AU - Motola,Juvenal,Jr AU - Laginha,Fábio Martins, AU - Kasuga,Yoshio, AU - Yokoyama,Shiro, AU - Onuma,Hiroshi, AU - Nishimura,Hideki, AU - Kusama,Ritsu, AU - Kobayashi,Minatsu, AU - Ishihara,Junko, AU - Yamamoto,Seiichiro, AU - Hanaoka,Tomoyuki, AU - Tsugane,Shoichiro, Y1 - 2008/09/06/ PY - 2008/07/21/received PY - 2008/08/20/accepted PY - 2008/9/9/pubmed PY - 2009/9/9/medline PY - 2008/9/9/entrez SP - 401 EP - 11 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 116 IS - 2 N2 - Although epidemiologic studies have shown an inverse association between isoflavones and breast cancer risk, little evidence for a dose-response relation is available. We conducted hospital-based case-control studies of patients aged 20-74 years with primary, incident, histologically confirmed invasive breast cancer, and matched controls from medical checkup examinees in Nagano, Japan and from cancer-free patients in São Paulo, Brazil. A total of 850 pairs (390 Japanese, 81 Japanese Brazilians and 379 non-Japanese Brazilians) completed validated food frequency questionnaires. The odds ratio of breast cancer according to isoflavone intake was estimated using a conditional logistic regression model. We found a statistically significant inverse association between isoflavone intake and the risk of breast cancer for Japanese Brazilians and non-Japanese Brazilians. For Japanese, a non-significant inverse association was limited to postmenopausal women. In the three populations combined, breast cancer risk linearly decreased from 'no' to 'moderate' isoflavone intake and thereafter leveled off. Compared to non-consumers, adjusted odds ratios (95% confidence interval) for consumers in increasing quintile intake categories (median intake in each category: 8.7, 23.1, 33.8, 45.7, and 71.3 mg/day) were 0.69 (0.44-1.09), 0.54 (0.31-0.94), 0.45 (0.26-0.77), 0.34 (0.19-0.62), and 0.43 (0.24-0.76), respectively. Overall, we found an inverse association between dietary isoflavone intake and risk of breast cancer. Our finding suggests a risk-reducing rather than risk-enhancing effect of isoflavones on breast cancer within the range achievable from dietary intake alone. In addition, women may benefit from risk reduction if they consume at least moderate amounts of isoflavones. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/18777206/Dietary_isoflavone_intake_and_breast_cancer_risk_in_case_control_studies_in_Japanese_Japanese_Brazilians_and_non_Japanese_Brazilians_ L2 - https://doi.org/10.1007/s10549-008-0168-1 DB - PRIME DP - Unbound Medicine ER -