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Autoimmune disorders in patients affected by celiac sprue and inflammatory bowel disease.
Ann Med 2009; 41(2):139-43AM

Abstract

BACKGROUND

Although clinically different, celiac sprue and inflammatory bowel disease are characterized by chronic intestinal inflammation and associated extraintestinal manifestations.

AIMS

To assess and compare the presence of autoimmune disorders in patients affected by celiac sprue and inflammatory bowel disease referred to a single tertiary centre.

METHODS

From October 2005 to January 2006, a total of 297 consecutive outpatients were enrolled in this cross-sectional study. Diagnoses of celiac sprue and inflammatory bowel disease were based on standard criteria. Data were recorded using an operator-assisted questionnaire: 18 autoimmune diseases, when adequately confirmed, were considered.

RESULTS

Clinical characteristics of our patients are in conformity with those of the literature. The prevalence of associated autoimmune diseases was 25.6%, 21.1%, and 10% in patients affected by celiac sprue, Crohn's disease, and ulcerative colitis. Between the prevalence in celiac sprue and Crohn's disease there was no difference, whereas a significant difference was present between these two diseases and ulcerative colitis. The most frequent disorder in all three groups was Hashimoto's thyroiditis.

CONCLUSIONS

Celiac sprue and Crohn's disease show similar prevalence of associated autoimmune disease, higher than the prevalence in ulcerative colitis. The two diseases share the same pathogenic immunologic response and altered intestinal permeability.

Authors+Show Affiliations

Centre for Prevention and Diagnosis of Celiac Disease, Fondazione IRCCS Ospedale Maggiore Policlinico, University of Milan, Italy. mariateresa.bardella@unimi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18777226

Citation

Bardella, Maria Teresa, et al. "Autoimmune Disorders in Patients Affected By Celiac Sprue and Inflammatory Bowel Disease." Annals of Medicine, vol. 41, no. 2, 2009, pp. 139-43.
Bardella MT, Elli L, De Matteis S, et al. Autoimmune disorders in patients affected by celiac sprue and inflammatory bowel disease. Ann Med. 2009;41(2):139-43.
Bardella, M. T., Elli, L., De Matteis, S., Floriani, I., Torri, V., & Piodi, L. (2009). Autoimmune disorders in patients affected by celiac sprue and inflammatory bowel disease. Annals of Medicine, 41(2), pp. 139-43. doi:10.1080/07853890802378817.
Bardella MT, et al. Autoimmune Disorders in Patients Affected By Celiac Sprue and Inflammatory Bowel Disease. Ann Med. 2009;41(2):139-43. PubMed PMID: 18777226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoimmune disorders in patients affected by celiac sprue and inflammatory bowel disease. AU - Bardella,Maria Teresa, AU - Elli,Luca, AU - De Matteis,Sara, AU - Floriani,Irene, AU - Torri,Valter, AU - Piodi,Luca, PY - 2008/9/9/pubmed PY - 2009/4/29/medline PY - 2008/9/9/entrez SP - 139 EP - 43 JF - Annals of medicine JO - Ann. Med. VL - 41 IS - 2 N2 - BACKGROUND: Although clinically different, celiac sprue and inflammatory bowel disease are characterized by chronic intestinal inflammation and associated extraintestinal manifestations. AIMS: To assess and compare the presence of autoimmune disorders in patients affected by celiac sprue and inflammatory bowel disease referred to a single tertiary centre. METHODS: From October 2005 to January 2006, a total of 297 consecutive outpatients were enrolled in this cross-sectional study. Diagnoses of celiac sprue and inflammatory bowel disease were based on standard criteria. Data were recorded using an operator-assisted questionnaire: 18 autoimmune diseases, when adequately confirmed, were considered. RESULTS: Clinical characteristics of our patients are in conformity with those of the literature. The prevalence of associated autoimmune diseases was 25.6%, 21.1%, and 10% in patients affected by celiac sprue, Crohn's disease, and ulcerative colitis. Between the prevalence in celiac sprue and Crohn's disease there was no difference, whereas a significant difference was present between these two diseases and ulcerative colitis. The most frequent disorder in all three groups was Hashimoto's thyroiditis. CONCLUSIONS: Celiac sprue and Crohn's disease show similar prevalence of associated autoimmune disease, higher than the prevalence in ulcerative colitis. The two diseases share the same pathogenic immunologic response and altered intestinal permeability. SN - 1365-2060 UR - https://www.unboundmedicine.com/medline/citation/18777226/Autoimmune_disorders_in_patients_affected_by_celiac_sprue_and_inflammatory_bowel_disease_ L2 - http://www.tandfonline.com/doi/full/10.1080/07853890802378817 DB - PRIME DP - Unbound Medicine ER -