TY - JOUR T1 - Quantification of lubricant activity of magnesium stearate by atomic force microscopy. AU - Weber,Daniel, AU - Pu,Yu, AU - Cooney,Charles L, PY - 2008/9/9/pubmed PY - 2008/11/19/medline PY - 2008/9/9/entrez SP - 1097 EP - 9 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 34 IS - 10 N2 - Magnesium stearate (MgSt) is commonly used in pharmaceutical formulations as a lubricant to facilitate tablet release from the die after compression. In this study, we quantify the effect of MgSt on the interaction forces between microcrystalline cellulose (MCC) and steel surfaces. A quantitative approach to better understand the mechanism by which MgSt affects powder performance will assist in improved control and formulation design. We find that the forces between MgSt and steel surface are stronger than the interactions between MgSt itself, between MgSt and an MCC particle, and an MCC particle and a steel surface. These quantitative findings offer an explanation how MgSt facilitates lubrication during tablet ejection. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/18777241/Quantification_of_lubricant_activity_of_magnesium_stearate_by_atomic_force_microscopy_ L2 - https://www.tandfonline.com/doi/full/10.1080/03639040801965061 DB - PRIME DP - Unbound Medicine ER -