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Apparent diffusion coefficient values in peripheral and transition zones of the prostate: comparison between normal and malignant prostatic tissues and correlation with histologic grade.
J Magn Reson Imaging. 2008 Sep; 28(3):720-6.JM

Abstract

PURPOSE

To investigate the utility of apparent diffusion coefficient (ADC) values for discriminating tumor in patients with prostate cancer from normal prostatic tissues in healthy adult men, and to identify correlations between ADC and histologic grade of prostate cancer.

MATERIALS AND METHODS

A total of 125 healthy male volunteers (mean age, 60 years; range, 50-86 years) and 90 prostate cancer patients (mean age, 71 years; range, 51-88 years) underwent diffusion-weighted imaging (DWI) of the prostate with a single-shot echo-planar imaging sequence using b-factors of 0 and 800 sec/mm2. ADC was measured from two locations in the peripheral zone (PZ) and two locations in the central gland (CG) in normal subjects, and tumor locations of PZ or transition zone (TZ) in patients with prostate cancer.

RESULTS

Mean ADC values of tumor regions in both PZ (1.02+/-0.25x10(-3) mm2/sec) and TZ (0.94+/-0.21x10(-3) mm2/sec) were significantly lower than those in the corresponding normal regions (1.80+/-0.27x10(-3) mm2/sec and 1.34+/-0.14x10(-3) mm2/sec, respectively) (P<0.0001 each). Furthermore, a significant negative correlation was identified between ADC in PZ cancer and tumor Gleason score (rho=-0.497, P<0.0001).

CONCLUSION

ADC values appear to provide acceptable diagnostic accuracy in both PZ and TZ.

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Authors+Show Affiliations

Tamada T
Department of Radiology, Kawasaki Medical School, Okayama, Japan. ttamada@med.kawasaki-m.ac.jp
Sone T
No affiliation info available
Jo Y
No affiliation info available
Toshimitsu S
No affiliation info available
Yamashita T
No affiliation info available
Yamamoto A
No affiliation info available
Tanimoto D
No affiliation info available
Ito K
No affiliation info available

MeSH

AgedAged, 80 and overAlgorithmsHumansImage EnhancementImage Interpretation, Computer-AssistedMaleMiddle AgedProstatic NeoplasmsReference ValuesReproducibility of ResultsSensitivity and SpecificityStatistics as Topic

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

18777532

Citation

Tamada, Tsutomu, et al. "Apparent Diffusion Coefficient Values in Peripheral and Transition Zones of the Prostate: Comparison Between Normal and Malignant Prostatic Tissues and Correlation With Histologic Grade." Journal of Magnetic Resonance Imaging : JMRI, vol. 28, no. 3, 2008, pp. 720-6.
Tamada T, Sone T, Jo Y, et al. Apparent diffusion coefficient values in peripheral and transition zones of the prostate: comparison between normal and malignant prostatic tissues and correlation with histologic grade. J Magn Reson Imaging. 2008;28(3):720-6.
Tamada, T., Sone, T., Jo, Y., Toshimitsu, S., Yamashita, T., Yamamoto, A., Tanimoto, D., & Ito, K. (2008). Apparent diffusion coefficient values in peripheral and transition zones of the prostate: comparison between normal and malignant prostatic tissues and correlation with histologic grade. Journal of Magnetic Resonance Imaging : JMRI, 28(3), 720-6. https://doi.org/10.1002/jmri.21503
Tamada T, et al. Apparent Diffusion Coefficient Values in Peripheral and Transition Zones of the Prostate: Comparison Between Normal and Malignant Prostatic Tissues and Correlation With Histologic Grade. J Magn Reson Imaging. 2008;28(3):720-6. PubMed PMID: 18777532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apparent diffusion coefficient values in peripheral and transition zones of the prostate: comparison between normal and malignant prostatic tissues and correlation with histologic grade. AU - Tamada,Tsutomu, AU - Sone,Teruki, AU - Jo,Yoshimasa, AU - Toshimitsu,Shinya, AU - Yamashita,Takenori, AU - Yamamoto,Akira, AU - Tanimoto,Daigo, AU - Ito,Katsuyoshi, PY - 2008/9/9/pubmed PY - 2008/12/31/medline PY - 2008/9/9/entrez SP - 720 EP - 6 JF - Journal of magnetic resonance imaging : JMRI JO - J Magn Reson Imaging VL - 28 IS - 3 N2 - PURPOSE: To investigate the utility of apparent diffusion coefficient (ADC) values for discriminating tumor in patients with prostate cancer from normal prostatic tissues in healthy adult men, and to identify correlations between ADC and histologic grade of prostate cancer. MATERIALS AND METHODS: A total of 125 healthy male volunteers (mean age, 60 years; range, 50-86 years) and 90 prostate cancer patients (mean age, 71 years; range, 51-88 years) underwent diffusion-weighted imaging (DWI) of the prostate with a single-shot echo-planar imaging sequence using b-factors of 0 and 800 sec/mm2. ADC was measured from two locations in the peripheral zone (PZ) and two locations in the central gland (CG) in normal subjects, and tumor locations of PZ or transition zone (TZ) in patients with prostate cancer. RESULTS: Mean ADC values of tumor regions in both PZ (1.02+/-0.25x10(-3) mm2/sec) and TZ (0.94+/-0.21x10(-3) mm2/sec) were significantly lower than those in the corresponding normal regions (1.80+/-0.27x10(-3) mm2/sec and 1.34+/-0.14x10(-3) mm2/sec, respectively) (P<0.0001 each). Furthermore, a significant negative correlation was identified between ADC in PZ cancer and tumor Gleason score (rho=-0.497, P<0.0001). CONCLUSION: ADC values appear to provide acceptable diagnostic accuracy in both PZ and TZ. SN - 1053-1807 UR - https://www.unboundmedicine.com/medline/citation/18777532/Apparent_diffusion_coefficient_values_in_peripheral_and_transition_zones_of_the_prostate:_comparison_between_normal_and_malignant_prostatic_tissues_and_correlation_with_histologic_grade_ L2 - https://doi.org/10.1002/jmri.21503 DB - PRIME DP - Unbound Medicine ER -