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Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids.

Abstract

Research on the chemistry and pharmacology of cannabinoids and endocannabinoids has reached enormous proportions, with approximately 15,000 articles on Cannabis sativa L. and cannabinoids and over 2,000 articles on endocannabinoids. The present review deals with the history of the Cannabis sativa L. plant, its uses, constituent compounds and their biogeneses, and similarity to compounds from Radula spp. In addition, details of the pharmacology of natural cannabinoids, as well as synthetic agonists and antagonists are presented. Finally, details regarding the pioneering isolation of the endocannabinoid anandamide, as well as the pharmacology and potential therapeutic uses of endocannabinoid congeners are presented.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, Hebrew University, Jerusalem, Israel. lumir@cc.huji.ac.il

    Source

    Medicinal research reviews 29:2 2009 Mar pg 213-71

    MeSH

    Brain
    Cannabinoid Receptor Modulators
    Cannabinoids
    Cannabis
    Plant Extracts

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    18777572

    Citation

    Hanus, Lumír Ondrej. "Pharmacological and Therapeutic Secrets of Plant and Brain (endo)cannabinoids." Medicinal Research Reviews, vol. 29, no. 2, 2009, pp. 213-71.
    Hanus LO. Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids. Med Res Rev. 2009;29(2):213-71.
    Hanus, L. O. (2009). Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids. Medicinal Research Reviews, 29(2), pp. 213-71. doi:10.1002/med.20135.
    Hanus LO. Pharmacological and Therapeutic Secrets of Plant and Brain (endo)cannabinoids. Med Res Rev. 2009;29(2):213-71. PubMed PMID: 18777572.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids. A1 - Hanus,Lumír Ondrej, PY - 2008/9/9/pubmed PY - 2009/3/18/medline PY - 2008/9/9/entrez SP - 213 EP - 71 JF - Medicinal research reviews JO - Med Res Rev VL - 29 IS - 2 N2 - Research on the chemistry and pharmacology of cannabinoids and endocannabinoids has reached enormous proportions, with approximately 15,000 articles on Cannabis sativa L. and cannabinoids and over 2,000 articles on endocannabinoids. The present review deals with the history of the Cannabis sativa L. plant, its uses, constituent compounds and their biogeneses, and similarity to compounds from Radula spp. In addition, details of the pharmacology of natural cannabinoids, as well as synthetic agonists and antagonists are presented. Finally, details regarding the pioneering isolation of the endocannabinoid anandamide, as well as the pharmacology and potential therapeutic uses of endocannabinoid congeners are presented. SN - 1098-1128 UR - https://www.unboundmedicine.com/medline/citation/18777572/Pharmacological_and_therapeutic_secrets_of_plant_and_brain__endo_cannabinoids_ L2 - https://doi.org/10.1002/med.20135 DB - PRIME DP - Unbound Medicine ER -