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Maize food allergy: a double-blind placebo-controlled study.
Clin Exp Allergy 2008; 38(12):1943-9CE

Abstract

BACKGROUND

Maize allergy is not very common especially in Europe. The number of studies that address IgE mediated maize allergy is all too few.

OBJECTIVE

Evaluate subjects with a history of maize allergy by double-blind, placebo-controlled food challenge; identify the spectrum of symptoms manifested during challenge; determine the lowest provocation dose (PD) during challenge; determine the performance characteristics of maize skin prick test and specific IgE.

METHODS

Twenty-seven patients with a history of maize allergy were enrolled to be evaluated by skin test, specific IgE and double-blind placebo-controlled maize challenge.

RESULTS

Forty-eight percent of the patients were challenge positive. PD range was 0.1-25 g. Fifty-four percent of the maize allergic subjects had a PD that was < or = 2.5 g; two subjects reacted to 100 mg of maize. Comparison of maize specific IgE levels and skin test results to the challenge results revealed the following (specific IgE level/skin testing): sensitivity 1.00/0.846, specificity 0.077/0.384, positive predictive value 0.520/0.579, and negative predictive value 1.00/0.714.

CONCLUSION

Maize is a cause of IgE-mediated allergic reactions to foods in adults and children. Nearly half of the subjects recruited were confirmed by challenge to be allergic to maize. Twenty-three percent of the positive challenge patients manifested symptoms that involved two organ systems, thus fulfilling the criteria for maize induced anaphylaxis. Maize is allergenic and can pose a risk for symptomatic food allergy at a dose of 100 mg.

Authors+Show Affiliations

Unit of Allergology and Clinical Immunology, A.O. Niguarda Hospital, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18778272

Citation

Scibilia, J, et al. "Maize Food Allergy: a Double-blind Placebo-controlled Study." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 38, no. 12, 2008, pp. 1943-9.
Scibilia J, Pastorello EA, Zisa G, et al. Maize food allergy: a double-blind placebo-controlled study. Clin Exp Allergy. 2008;38(12):1943-9.
Scibilia, J., Pastorello, E. A., Zisa, G., Ottolenghi, A., Ballmer-Weber, B., Pravettoni, V., ... Ortolani, C. (2008). Maize food allergy: a double-blind placebo-controlled study. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 38(12), pp. 1943-9. doi:10.1111/j.1365-2222.2008.03094.x.
Scibilia J, et al. Maize Food Allergy: a Double-blind Placebo-controlled Study. Clin Exp Allergy. 2008;38(12):1943-9. PubMed PMID: 18778272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maize food allergy: a double-blind placebo-controlled study. AU - Scibilia,J, AU - Pastorello,E A, AU - Zisa,G, AU - Ottolenghi,A, AU - Ballmer-Weber,B, AU - Pravettoni,V, AU - Scovena,E, AU - Robino,A, AU - Ortolani,C, Y1 - 2008/09/04/ PY - 2008/9/10/pubmed PY - 2009/2/12/medline PY - 2008/9/10/entrez SP - 1943 EP - 9 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 38 IS - 12 N2 - BACKGROUND: Maize allergy is not very common especially in Europe. The number of studies that address IgE mediated maize allergy is all too few. OBJECTIVE: Evaluate subjects with a history of maize allergy by double-blind, placebo-controlled food challenge; identify the spectrum of symptoms manifested during challenge; determine the lowest provocation dose (PD) during challenge; determine the performance characteristics of maize skin prick test and specific IgE. METHODS: Twenty-seven patients with a history of maize allergy were enrolled to be evaluated by skin test, specific IgE and double-blind placebo-controlled maize challenge. RESULTS: Forty-eight percent of the patients were challenge positive. PD range was 0.1-25 g. Fifty-four percent of the maize allergic subjects had a PD that was < or = 2.5 g; two subjects reacted to 100 mg of maize. Comparison of maize specific IgE levels and skin test results to the challenge results revealed the following (specific IgE level/skin testing): sensitivity 1.00/0.846, specificity 0.077/0.384, positive predictive value 0.520/0.579, and negative predictive value 1.00/0.714. CONCLUSION: Maize is a cause of IgE-mediated allergic reactions to foods in adults and children. Nearly half of the subjects recruited were confirmed by challenge to be allergic to maize. Twenty-three percent of the positive challenge patients manifested symptoms that involved two organ systems, thus fulfilling the criteria for maize induced anaphylaxis. Maize is allergenic and can pose a risk for symptomatic food allergy at a dose of 100 mg. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/18778272/full_citation/Maize_food_allergy:_a_double_blind_placebo_controlled_study_ L2 - https://doi.org/10.1111/j.1365-2222.2008.03094.x DB - PRIME DP - Unbound Medicine ER -