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Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status.
Clin Exp Immunol 2008; 154(2):172-6CE

Abstract

The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Anti-thyroid peroxidase antibody (TPOAb), a diagnostic hallmark of HT, is principally of the immunoglobulin G (IgG) isotype, and it appears to be a response to thyroid injury. The aim of our study was to evaluate the distribution of IgG subclasses of TPOAb in sera from patients with HT with different thyroid functional status. Sera from 168 patients with newly diagnosed HT were collected and divided into three groups according to thyroid function: patients with hypothyroidism (n = 66), subclinical hypothyroidism (n = 60) and euthyroidism (n = 42). Antigen-specific enzyme-linked immunosorbent assay was used to detect the distribution of TPOAb IgG subclasses. The prevalence of TPOAb IgG subclasses in all patients' sera with HT was IgG1 70.2%, IgG2 35.1%, IgG3 19.6% and IgG4 66.1% respectively. The prevalence of IgG2 in sera from patients with hypothyroidism (51.5%) was significantly higher than that of subclinical hypothyroidism (33.3%) (P < 0.05), and the latter was also significantly higher than that of euthyroidism (11.9%) (P < 0.05). The positive percentage of IgG2 subclass in sera from patients with hypothyroidism and subclinical hypothyroidism was significantly higher than that of euthyroidism (P < 0.05), the prevalence and positive percentage of IgG4 subclass in sera from patients with hypothyroidism and subclinical hypothyroidism was significantly higher than that of euthyroidism respectively (P < 0.05). The predominant TPOAb IgG subclasses in sera from patients with HT were IgG1 and IgG4. Patients with high levels of TPOAb IgG2, IgG4 subclasses might be at high risk of developing overt hypothyroidism.

Authors+Show Affiliations

Department of Endocrinology, Peking University First Hospital, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18778360

Citation

Xie, L-D, et al. "Distribution of Immunoglobulin G Subclasses of Anti-thyroid Peroxidase Antibody in Sera From Patients With Hashimoto's Thyroiditis With Different Thyroid Functional Status." Clinical and Experimental Immunology, vol. 154, no. 2, 2008, pp. 172-6.
Xie LD, Gao Y, Li MR, et al. Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status. Clin Exp Immunol. 2008;154(2):172-6.
Xie, L. D., Gao, Y., Li, M. R., Lu, G. Z., & Guo, X. H. (2008). Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status. Clinical and Experimental Immunology, 154(2), pp. 172-6. doi:10.1111/j.1365-2249.2008.03756.x.
Xie LD, et al. Distribution of Immunoglobulin G Subclasses of Anti-thyroid Peroxidase Antibody in Sera From Patients With Hashimoto's Thyroiditis With Different Thyroid Functional Status. Clin Exp Immunol. 2008;154(2):172-6. PubMed PMID: 18778360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status. AU - Xie,L-D, AU - Gao,Y, AU - Li,M-R, AU - Lu,G-Z, AU - Guo,X-H, Y1 - 2008/09/05/ PY - 2008/9/10/pubmed PY - 2008/12/17/medline PY - 2008/9/10/entrez SP - 172 EP - 6 JF - Clinical and experimental immunology JO - Clin. Exp. Immunol. VL - 154 IS - 2 N2 - The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Anti-thyroid peroxidase antibody (TPOAb), a diagnostic hallmark of HT, is principally of the immunoglobulin G (IgG) isotype, and it appears to be a response to thyroid injury. The aim of our study was to evaluate the distribution of IgG subclasses of TPOAb in sera from patients with HT with different thyroid functional status. Sera from 168 patients with newly diagnosed HT were collected and divided into three groups according to thyroid function: patients with hypothyroidism (n = 66), subclinical hypothyroidism (n = 60) and euthyroidism (n = 42). Antigen-specific enzyme-linked immunosorbent assay was used to detect the distribution of TPOAb IgG subclasses. The prevalence of TPOAb IgG subclasses in all patients' sera with HT was IgG1 70.2%, IgG2 35.1%, IgG3 19.6% and IgG4 66.1% respectively. The prevalence of IgG2 in sera from patients with hypothyroidism (51.5%) was significantly higher than that of subclinical hypothyroidism (33.3%) (P < 0.05), and the latter was also significantly higher than that of euthyroidism (11.9%) (P < 0.05). The positive percentage of IgG2 subclass in sera from patients with hypothyroidism and subclinical hypothyroidism was significantly higher than that of euthyroidism (P < 0.05), the prevalence and positive percentage of IgG4 subclass in sera from patients with hypothyroidism and subclinical hypothyroidism was significantly higher than that of euthyroidism respectively (P < 0.05). The predominant TPOAb IgG subclasses in sera from patients with HT were IgG1 and IgG4. Patients with high levels of TPOAb IgG2, IgG4 subclasses might be at high risk of developing overt hypothyroidism. SN - 1365-2249 UR - https://www.unboundmedicine.com/medline/citation/18778360/Distribution_of_immunoglobulin_G_subclasses_of_anti_thyroid_peroxidase_antibody_in_sera_from_patients_with_Hashimoto's_thyroiditis_with_different_thyroid_functional_status_ L2 - https://doi.org/10.1111/j.1365-2249.2008.03756.x DB - PRIME DP - Unbound Medicine ER -