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Dose-dependent effects of walnuts on motor and cognitive function in aged rats.
Br J Nutr. 2009 Apr; 101(8):1140-4.BJ

Abstract

Aged rats show decrements in performance on motor and cognitive tasks that require the use of spatial learning and memory. Previously we have shown that these deficits can be reversed by the polyphenolics in fruits and vegetables. Walnuts, which contain the n-3 fatty acids a-linolenic acid and linoleic acid, are a dietary source of polyphenols, antioxidants and lipids. Thus, the present study examined the effects of walnut supplementation on motor and cognitive ability in aged rats. Fischer 344 rats, aged 19 months, were fed a control, or a 2, 6 or 9% walnut diet for 8 weeks before motor and cognitive testing. Results for the motor testing showed that the 2% walnut diet improved performance on rod walking, while the 6% walnut diet improved performance on the medium plank walk; the higher dose of the 9% walnut diet did not improve psychomotor performance and on the large plank actually impaired performance. All of the walnut diets improved working memory in the Morris water maze, although the 9% diet showed impaired reference memory. These findings show for the first time that moderate dietary walnut supplementation can improve cognitive and motor performance in aged rats.

Authors+Show Affiliations

USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18778529

Citation

Willis, Lauren M., et al. "Dose-dependent Effects of Walnuts On Motor and Cognitive Function in Aged Rats." The British Journal of Nutrition, vol. 101, no. 8, 2009, pp. 1140-4.
Willis LM, Shukitt-Hale B, Cheng V, et al. Dose-dependent effects of walnuts on motor and cognitive function in aged rats. Br J Nutr. 2009;101(8):1140-4.
Willis, L. M., Shukitt-Hale, B., Cheng, V., & Joseph, J. A. (2009). Dose-dependent effects of walnuts on motor and cognitive function in aged rats. The British Journal of Nutrition, 101(8), 1140-4. https://doi.org/10.1017/S0007114508059369
Willis LM, et al. Dose-dependent Effects of Walnuts On Motor and Cognitive Function in Aged Rats. Br J Nutr. 2009;101(8):1140-4. PubMed PMID: 18778529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dose-dependent effects of walnuts on motor and cognitive function in aged rats. AU - Willis,Lauren M, AU - Shukitt-Hale,Barbara, AU - Cheng,Vivian, AU - Joseph,James A, PY - 2008/9/10/pubmed PY - 2009/7/9/medline PY - 2008/9/10/entrez SP - 1140 EP - 4 JF - The British journal of nutrition JO - Br J Nutr VL - 101 IS - 8 N2 - Aged rats show decrements in performance on motor and cognitive tasks that require the use of spatial learning and memory. Previously we have shown that these deficits can be reversed by the polyphenolics in fruits and vegetables. Walnuts, which contain the n-3 fatty acids a-linolenic acid and linoleic acid, are a dietary source of polyphenols, antioxidants and lipids. Thus, the present study examined the effects of walnut supplementation on motor and cognitive ability in aged rats. Fischer 344 rats, aged 19 months, were fed a control, or a 2, 6 or 9% walnut diet for 8 weeks before motor and cognitive testing. Results for the motor testing showed that the 2% walnut diet improved performance on rod walking, while the 6% walnut diet improved performance on the medium plank walk; the higher dose of the 9% walnut diet did not improve psychomotor performance and on the large plank actually impaired performance. All of the walnut diets improved working memory in the Morris water maze, although the 9% diet showed impaired reference memory. These findings show for the first time that moderate dietary walnut supplementation can improve cognitive and motor performance in aged rats. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/18778529/Dose_dependent_effects_of_walnuts_on_motor_and_cognitive_function_in_aged_rats_ L2 - https://www.cambridge.org/core/product/identifier/S0007114508059369/type/journal_article DB - PRIME DP - Unbound Medicine ER -