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Diffuse keratoconjunctival proliferation: a novel clinical manifestation.
Arch Ophthalmol. 2008 Sep; 126(9):1226-32.AO

Abstract

OBJECTIVE

To report a previously unrecognized benign bilateral widespread conjunctival and corneal proliferative condition with a potential to affect vision.

METHODS

A gradually progressive diffuse conjunctival proliferation extending on the cornea was noted in 14 patients (28 eyes). These patients were followed up for a mean of 6 years for the site, extent, and progression of the condition. Six eyes had these lesions removed and studied histopathologically.

RESULTS

Patients included 6 men and 8 women (mean age, 57 years). Two patients had bilateral nasal lesions only, 1 patient had bilateral temporal lesions only, 6 patients had both nasal and temporal lesions, and 5 patients had lesions that extended circumferentially. Pathology reports showed dense collagenous tissue, a moderate number of active fibroblasts, numerous blood vessels, and no elastotic degeneration in 3 of the 6 eyes. Two eyes showed mild subepithelial elastotic degeneration, and 1 lesion was difficult to interpret because of excessive intraconjunctival hemorrhage. None showed any inflammatory activity.

CONCLUSIONS

The lesions appear to be a clinical variant of classic pterygium with the corneal encroachment being wider, irregular, and more extensive. Histologically, a noninflammatory nonelastotic collagenous accumulation appears to be a predominant feature unlike in classic pterygium where elastotic degeneration is the predominant feature.

Authors+Show Affiliations

Division of Ophthalmology and Visual Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, England.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18779482

Citation

Said, Dalia G., et al. "Diffuse Keratoconjunctival Proliferation: a Novel Clinical Manifestation." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 126, no. 9, 2008, pp. 1226-32.
Said DG, Mathew M, Shaikh MY, et al. Diffuse keratoconjunctival proliferation: a novel clinical manifestation. Arch Ophthalmol. 2008;126(9):1226-32.
Said, D. G., Mathew, M., Shaikh, M. Y., Maharajan, V. S., Lowe, J., & Dua, H. S. (2008). Diffuse keratoconjunctival proliferation: a novel clinical manifestation. Archives of Ophthalmology (Chicago, Ill. : 1960), 126(9), 1226-32. https://doi.org/10.1001/archopht.126.9.1226
Said DG, et al. Diffuse Keratoconjunctival Proliferation: a Novel Clinical Manifestation. Arch Ophthalmol. 2008;126(9):1226-32. PubMed PMID: 18779482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diffuse keratoconjunctival proliferation: a novel clinical manifestation. AU - Said,Dalia G, AU - Mathew,Manu, AU - Shaikh,M Yusuf, AU - Maharajan,V Senthil, AU - Lowe,James, AU - Dua,Harminder S, PY - 2008/9/10/pubmed PY - 2008/9/23/medline PY - 2008/9/10/entrez SP - 1226 EP - 32 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch Ophthalmol VL - 126 IS - 9 N2 - OBJECTIVE: To report a previously unrecognized benign bilateral widespread conjunctival and corneal proliferative condition with a potential to affect vision. METHODS: A gradually progressive diffuse conjunctival proliferation extending on the cornea was noted in 14 patients (28 eyes). These patients were followed up for a mean of 6 years for the site, extent, and progression of the condition. Six eyes had these lesions removed and studied histopathologically. RESULTS: Patients included 6 men and 8 women (mean age, 57 years). Two patients had bilateral nasal lesions only, 1 patient had bilateral temporal lesions only, 6 patients had both nasal and temporal lesions, and 5 patients had lesions that extended circumferentially. Pathology reports showed dense collagenous tissue, a moderate number of active fibroblasts, numerous blood vessels, and no elastotic degeneration in 3 of the 6 eyes. Two eyes showed mild subepithelial elastotic degeneration, and 1 lesion was difficult to interpret because of excessive intraconjunctival hemorrhage. None showed any inflammatory activity. CONCLUSIONS: The lesions appear to be a clinical variant of classic pterygium with the corneal encroachment being wider, irregular, and more extensive. Histologically, a noninflammatory nonelastotic collagenous accumulation appears to be a predominant feature unlike in classic pterygium where elastotic degeneration is the predominant feature. SN - 1538-3601 UR - https://www.unboundmedicine.com/medline/citation/18779482/Diffuse_keratoconjunctival_proliferation:_a_novel_clinical_manifestation L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/archopht.126.9.1226 DB - PRIME DP - Unbound Medicine ER -