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The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23.

Abstract

OBJECTIVE

To examine the association of dietary omega-3 long-chain polyunsaturated fatty acid and fish intake with incident neovascular age-related macular degeneration (AMD) and central geographic atrophy (CGA).

METHODS

Multicenter clinic-based prospective cohort study from a clinical trial including Age-Related Eye Disease Study (AREDS) participants with bilateral drusen at enrollment. Main outcome measures were incident neovascular AMD and CGA, ascertained from annual stereoscopic color fundus photographs (median follow-up, 6.3 years). We estimated nutrient and food intake from a validated food frequency questionnaire (FFQ) at baseline, with intake of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), combined EPA and DHA, and fish as primary exposures.

RESULTS

After controlling for known covariates, we observed a reduced likelihood of progression from bilateral drusen to CGA among people who reported the highest levels of EPA (odds ratio [OR], 0.44; 95% confidence interval [CI], 0.23-0.87) and EPA+DHA (OR, 0.45; 95% CI, 0.23-0.90) consumption. Levels of DHA were associated with CGA in age-, sex-, and calorie-adjusted models (OR, 0.51; 95% CI, 0.26-1.00); however, this statistical relationship did not persist in multivariable models.

CONCLUSIONS

Dietary lipid intake is a modifiable factor that may influence the likelihood of developing sight-threatening forms of AMD. Our findings suggest that dietary omega-3 long-chain polyunsaturated fatty acid intake is associated with a decreased risk of progression from bilateral drusen to CGA.

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  • Authors+Show Affiliations

    ,

    National Eye Institute, Bethesda, Maryland, USA.

    , , , , , , , , , ,

    Source

    MeSH

    Aged
    Atrophy
    Choroidal Neovascularization
    Diet Surveys
    Dietary Fats, Unsaturated
    Disease Progression
    Docosahexaenoic Acids
    Eicosapentaenoic Acid
    Energy Intake
    Fatty Acids, Omega-3
    Feeding Behavior
    Female
    Humans
    Incidence
    Macular Degeneration
    Male
    Odds Ratio
    Pigment Epithelium of Eye
    Prospective Studies
    Retinal Drusen
    Seafood
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Clinical Trial
    Journal Article
    Multicenter Study
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    18779490

    Citation

    SanGiovanni, John Paul, et al. "The Relationship of Dietary Omega-3 Long-chain Polyunsaturated Fatty Acid Intake With Incident Age-related Macular Degeneration: AREDS Report No. 23." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 126, no. 9, 2008, pp. 1274-9.
    SanGiovanni JP, Chew EY, Agrón E, et al. The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23. Arch Ophthalmol. 2008;126(9):1274-9.
    SanGiovanni, J. P., Chew, E. Y., Agrón, E., Clemons, T. E., Ferris, F. L., Gensler, G., ... Sperduto, R. D. (2008). The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23. Archives of Ophthalmology (Chicago, Ill. : 1960), 126(9), pp. 1274-9. doi:10.1001/archopht.126.9.1274.
    SanGiovanni JP, et al. The Relationship of Dietary Omega-3 Long-chain Polyunsaturated Fatty Acid Intake With Incident Age-related Macular Degeneration: AREDS Report No. 23. Arch Ophthalmol. 2008;126(9):1274-9. PubMed PMID: 18779490.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23. AU - SanGiovanni,John Paul, AU - Chew,Emily Y, AU - Agrón,Elvira, AU - Clemons,Traci E, AU - Ferris,Frederick L,3rd AU - Gensler,Gary, AU - Lindblad,Anne S, AU - Milton,Roy C, AU - Seddon,Johanna M, AU - Klein,Ronald, AU - Sperduto,Robert D, AU - ,, PY - 2008/9/10/pubmed PY - 2008/9/23/medline PY - 2008/9/10/entrez SP - 1274 EP - 9 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 126 IS - 9 N2 - OBJECTIVE: To examine the association of dietary omega-3 long-chain polyunsaturated fatty acid and fish intake with incident neovascular age-related macular degeneration (AMD) and central geographic atrophy (CGA). METHODS: Multicenter clinic-based prospective cohort study from a clinical trial including Age-Related Eye Disease Study (AREDS) participants with bilateral drusen at enrollment. Main outcome measures were incident neovascular AMD and CGA, ascertained from annual stereoscopic color fundus photographs (median follow-up, 6.3 years). We estimated nutrient and food intake from a validated food frequency questionnaire (FFQ) at baseline, with intake of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), combined EPA and DHA, and fish as primary exposures. RESULTS: After controlling for known covariates, we observed a reduced likelihood of progression from bilateral drusen to CGA among people who reported the highest levels of EPA (odds ratio [OR], 0.44; 95% confidence interval [CI], 0.23-0.87) and EPA+DHA (OR, 0.45; 95% CI, 0.23-0.90) consumption. Levels of DHA were associated with CGA in age-, sex-, and calorie-adjusted models (OR, 0.51; 95% CI, 0.26-1.00); however, this statistical relationship did not persist in multivariable models. CONCLUSIONS: Dietary lipid intake is a modifiable factor that may influence the likelihood of developing sight-threatening forms of AMD. Our findings suggest that dietary omega-3 long-chain polyunsaturated fatty acid intake is associated with a decreased risk of progression from bilateral drusen to CGA. SN - 1538-3601 UR - https://www.unboundmedicine.com/medline/citation/18779490/The_relationship_of_dietary_omega_3_long_chain_polyunsaturated_fatty_acid_intake_with_incident_age_related_macular_degeneration:_AREDS_report_no__23_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/archopht.126.9.1274 DB - PRIME DP - Unbound Medicine ER -