Tags

Type your tag names separated by a space and hit enter

A proposed classification system for menstrual cycles in the menopause transition based on changes in serum hormone profiles.
Menopause. 2008 Nov-Dec; 15(6):1139-44.M

Abstract

OBJECTIVE

To characterize menstrual cycles in women in late reproductive age and the menopause transition, based on changes in serum hormone levels.

DESIGN

Serum levels of estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone, inhibin A, inhibin B, and antimüllerian hormone, as previously reported as mean data grouped according to the Stages of Reproductive Aging Workshop proposals, were analyzed in 55 women aged 45 to 55 and compared with those in 21 women aged 21 to 35.

RESULTS

The ovulatory cycles in the older women were divided into three types. Type 1 cycles (n = 14, 33%) were those with hormone concentrations similar to the women aged 21 to 35 except for 20-fold lower antimüllerian hormone levels. Type 2 cycles (n = 24; 53%) had increased FSH, decreased inhibin B, and increased FSH-to-inhibin B ratios but normal estradiol and progesterone levels. Type 3 cycles had the same characteristics as type 2 cycles (n = 5; 12%) in addition to lower luteal phase progesterone and increased luteinizing hormone.

CONCLUSIONS

The changes in hormone levels indicated in cycle types 1 to 3 closely reflect the changes in ovarian-pituitary activity as menopause approaches and are likely to be directly attributable to a decrease in ovarian follicle reserve. The findings suggest that FSH-to-inhibin B ratios and antimüllerian hormone are distinct early indicators of the menopause transition and are likely to be useful biomarkers of impending menopause. Furthermore, this classification may provide an improved basis for the study of reproductive endocrine disorders associated with the menopause transition.

Authors+Show Affiliations

Prince Henry's Institute, Monash Medical Centre, Clayton, Victoria, Australia. david.robertson@princehenrys.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18779761

Citation

Robertson, David M., et al. "A Proposed Classification System for Menstrual Cycles in the Menopause Transition Based On Changes in Serum Hormone Profiles." Menopause (New York, N.Y.), vol. 15, no. 6, 2008, pp. 1139-44.
Robertson DM, Hale GE, Fraser IS, et al. A proposed classification system for menstrual cycles in the menopause transition based on changes in serum hormone profiles. Menopause. 2008;15(6):1139-44.
Robertson, D. M., Hale, G. E., Fraser, I. S., Hughes, C. L., & Burger, H. G. (2008). A proposed classification system for menstrual cycles in the menopause transition based on changes in serum hormone profiles. Menopause (New York, N.Y.), 15(6), 1139-44. https://doi.org/10.1097/gme.0b013e3181735687
Robertson DM, et al. A Proposed Classification System for Menstrual Cycles in the Menopause Transition Based On Changes in Serum Hormone Profiles. Menopause. 2008 Nov-Dec;15(6):1139-44. PubMed PMID: 18779761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A proposed classification system for menstrual cycles in the menopause transition based on changes in serum hormone profiles. AU - Robertson,David M, AU - Hale,Georgina E, AU - Fraser,Ian S, AU - Hughes,Claude L, AU - Burger,Henry G, PY - 2008/9/10/pubmed PY - 2009/4/2/medline PY - 2008/9/10/entrez SP - 1139 EP - 44 JF - Menopause (New York, N.Y.) JO - Menopause VL - 15 IS - 6 N2 - OBJECTIVE: To characterize menstrual cycles in women in late reproductive age and the menopause transition, based on changes in serum hormone levels. DESIGN: Serum levels of estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone, inhibin A, inhibin B, and antimüllerian hormone, as previously reported as mean data grouped according to the Stages of Reproductive Aging Workshop proposals, were analyzed in 55 women aged 45 to 55 and compared with those in 21 women aged 21 to 35. RESULTS: The ovulatory cycles in the older women were divided into three types. Type 1 cycles (n = 14, 33%) were those with hormone concentrations similar to the women aged 21 to 35 except for 20-fold lower antimüllerian hormone levels. Type 2 cycles (n = 24; 53%) had increased FSH, decreased inhibin B, and increased FSH-to-inhibin B ratios but normal estradiol and progesterone levels. Type 3 cycles had the same characteristics as type 2 cycles (n = 5; 12%) in addition to lower luteal phase progesterone and increased luteinizing hormone. CONCLUSIONS: The changes in hormone levels indicated in cycle types 1 to 3 closely reflect the changes in ovarian-pituitary activity as menopause approaches and are likely to be directly attributable to a decrease in ovarian follicle reserve. The findings suggest that FSH-to-inhibin B ratios and antimüllerian hormone are distinct early indicators of the menopause transition and are likely to be useful biomarkers of impending menopause. Furthermore, this classification may provide an improved basis for the study of reproductive endocrine disorders associated with the menopause transition. SN - 1530-0374 UR - https://www.unboundmedicine.com/medline/citation/18779761/A_proposed_classification_system_for_menstrual_cycles_in_the_menopause_transition_based_on_changes_in_serum_hormone_profiles_ L2 - https://doi.org/10.1097/gme.0b013e3181735687 DB - PRIME DP - Unbound Medicine ER -