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In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi.
Nat Prod Res. 2008; 22(12):1040-6.NP

Abstract

This study describes the antichagasic potential of five compounds isolated from leaves of Piper crassinervium (Piperaceae). Two prenylated benzoic acid derivatives, one prenylated hydroquinone and two flavanones, were evaluated. The in vitro trypanocidal activity was determined against epimastigote forms of Trypanosoma cruzi (Y strain), the etiologic agent of Chagas disease. The most active compound was the prenylated hydroquinone [1,4-dihydroxy-2-(3(0),7(0)-dimethyl-1(0)-oxo-2(0)-E,6(0)-octadienyl)benzene] with an IC(50) value of 6.10 microg mL(-1), which was in the same order of activity if compared with the positive control benznidazole (IC(50) = 1.60 microg mL(-1)). This is the first report of trypanocidal activity for prenylated hydroquinone and benzoic acid derivatives.

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Authors+Show Affiliations

Lopes AA
Instituto de Quimica, Universidade Estadual Paulista, Araraquara, SP, Brazil.
López SN
No affiliation info available
Regasini LO
No affiliation info available
Junior JM
No affiliation info available
Ambrósio DL
No affiliation info available
Kato MJ
No affiliation info available
da Silva Bolzani V
No affiliation info available
Cicarelli RM
No affiliation info available
Furlan M
No affiliation info available

MeSH

AnimalsPiperPlant ExtractsTrypanocidal AgentsTrypanosoma cruzi

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18780244

Citation

Lopes, Adriana Aparecida, et al. "In Vitro Activity of Compounds Isolated From Piper Crassinervium Against Trypanosoma Cruzi." Natural Product Research, vol. 22, no. 12, 2008, pp. 1040-6.
Lopes AA, López SN, Regasini LO, et al. In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi. Nat Prod Res. 2008;22(12):1040-6.
Lopes, A. A., López, S. N., Regasini, L. O., Junior, J. M., Ambrósio, D. L., Kato, M. J., da Silva Bolzani, V., Cicarelli, R. M., & Furlan, M. (2008). In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi. Natural Product Research, 22(12), 1040-6. https://doi.org/10.1080/14786410802243271
Lopes AA, et al. In Vitro Activity of Compounds Isolated From Piper Crassinervium Against Trypanosoma Cruzi. Nat Prod Res. 2008;22(12):1040-6. PubMed PMID: 18780244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi. AU - Lopes,Adriana Aparecida, AU - López,Silvia Noelí, AU - Regasini,Luis Octávio, AU - Junior,João Marcos Batista, AU - Ambrósio,Daniela Luz, AU - Kato,Massuo Jorge, AU - da Silva Bolzani,Vanderlan, AU - Cicarelli,Regina Maria Barretto, AU - Furlan,Maysa, PY - 2008/9/10/pubmed PY - 2008/12/17/medline PY - 2008/9/10/entrez SP - 1040 EP - 6 JF - Natural product research JO - Nat Prod Res VL - 22 IS - 12 N2 - This study describes the antichagasic potential of five compounds isolated from leaves of Piper crassinervium (Piperaceae). Two prenylated benzoic acid derivatives, one prenylated hydroquinone and two flavanones, were evaluated. The in vitro trypanocidal activity was determined against epimastigote forms of Trypanosoma cruzi (Y strain), the etiologic agent of Chagas disease. The most active compound was the prenylated hydroquinone [1,4-dihydroxy-2-(3(0),7(0)-dimethyl-1(0)-oxo-2(0)-E,6(0)-octadienyl)benzene] with an IC(50) value of 6.10 microg mL(-1), which was in the same order of activity if compared with the positive control benznidazole (IC(50) = 1.60 microg mL(-1)). This is the first report of trypanocidal activity for prenylated hydroquinone and benzoic acid derivatives. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/18780244/In_vitro_activity_of_compounds_isolated_from_Piper_crassinervium_against_Trypanosoma_cruzi_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786410802243271 DB - PRIME DP - Unbound Medicine ER -