Lopes, Adriana Aparecida, et al. "In Vitro Activity of Compounds Isolated From Piper Crassinervium Against Trypanosoma Cruzi." Natural Product Research, vol. 22, no. 12, 2008, pp. 1040-6.
Lopes AA, López SN, Regasini LO, et al. In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi. Nat Prod Res. 2008;22(12):1040-6.
Lopes, A. A., López, S. N., Regasini, L. O., Junior, J. M., Ambrósio, D. L., Kato, M. J., da Silva Bolzani, V., Cicarelli, R. M., & Furlan, M. (2008). In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi. Natural Product Research, 22(12), 1040-6. https://doi.org/10.1080/14786410802243271
Lopes AA, et al. In Vitro Activity of Compounds Isolated From Piper Crassinervium Against Trypanosoma Cruzi. Nat Prod Res. 2008;22(12):1040-6. PubMed PMID: 18780244.
TY - JOUR
T1 - In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi.
AU - Lopes,Adriana Aparecida,
AU - López,Silvia Noelí,
AU - Regasini,Luis Octávio,
AU - Junior,João Marcos Batista,
AU - Ambrósio,Daniela Luz,
AU - Kato,Massuo Jorge,
AU - da Silva Bolzani,Vanderlan,
AU - Cicarelli,Regina Maria Barretto,
AU - Furlan,Maysa,
PY - 2008/9/10/pubmed
PY - 2008/12/17/medline
PY - 2008/9/10/entrez
SP - 1040
EP - 6
JF - Natural product research
JO - Nat Prod Res
VL - 22
IS - 12
N2 - This study describes the antichagasic potential of five compounds isolated from leaves of Piper crassinervium (Piperaceae). Two prenylated benzoic acid derivatives, one prenylated hydroquinone and two flavanones, were evaluated. The in vitro trypanocidal activity was determined against epimastigote forms of Trypanosoma cruzi (Y strain), the etiologic agent of Chagas disease. The most active compound was the prenylated hydroquinone [1,4-dihydroxy-2-(3(0),7(0)-dimethyl-1(0)-oxo-2(0)-E,6(0)-octadienyl)benzene] with an IC(50) value of 6.10 microg mL(-1), which was in the same order of activity if compared with the positive control benznidazole (IC(50) = 1.60 microg mL(-1)). This is the first report of trypanocidal activity for prenylated hydroquinone and benzoic acid derivatives.
SN - 1478-6427
UR - https://www.unboundmedicine.com/medline/citation/18780244/In_vitro_activity_of_compounds_isolated_from_Piper_crassinervium_against_Trypanosoma_cruzi_
L2 - https://www.tandfonline.com/doi/full/10.1080/14786410802243271
DB - PRIME
DP - Unbound Medicine