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Cardiac troponins and left ventricular hypertrophy in hemodialysis patients.
Clin Lab. 2008; 54(5-6):145-52.CL

Abstract

BACKGROUND

Cardiovascular diseases are the leading cause of death in hemodialysis patients. Left ventricular (LV) hypertrophy is an important predictor of cardiovascular morbidity and mortality in these patients. Cardiac troponins (cTnT and cTnI) are indicators of myocardial cell damage.

AIM

The aim of this study was to determine prevalence of LV hypertrophy, prevalence of elevated serum cTnT and cTnI in hemodialysis patients, and identify the correlation between cardiac troponins and LV hypertrophy.

METHODS

The study included 115 hemodialysis patients (71 men and 44 women), mean age 53.30 +/- 12.17 years, mean time on dialysis 4.51 +/- 4.01 years and average Kt/Vsp 1.17 +/- 0.23. Mean serum cTnT was 0.14 +/- 0.23 ng/ml, mean serum troponin I 0.20 +/- 0.48 ng/ml. Mean LV posterior wall thickness in diastole (LVPWd) was 11.44 +/- 2.09 mm, mean LV interventricular septal wall thickness in diastole (IVSd) 11.21 +/- 2.12 mm, mean LV end diastolic volume index (iLVEDV) 100.80 +/- 34.62 mL/m2 and mean LV mass index (LVMi) 143.85 +/- 41.21 g/m2.

RESULTS

We found statistically significant positive correlations (p <0.05) between serum troponin T concentration, IVSd, LVPWd and iLVEDV. A highly significant positive correlation (p < 0.01) was found between serum troponin T and LVMi. One-year follow-up showed that patients with cardiac troponin T > 0.10 ng/ml and cardiac troponin I > 0.15 ng/ml had significantly lower (p < 0.01) survival rate than patients with troponin T < or = 0.10 ng/ml and troponin I < or = 0.15 ng/ml.

CONCLUSION

A significant positive correlation exists between serum troponin T concentration and echocardiographic indicators of LV hypertrophy in hemodialysis patients. Patients with higher serum levels of cardiac troponins have lower survival rates during one year follow up.

Authors+Show Affiliations

Clinic of Urology and Nephrology, Department of Haemodialysis, Clinical Centre "Kragujevac", Kragujevac, Serbia. aca96@Eunet.yuNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18780659

Citation

Petrović, Dejan, et al. "Cardiac Troponins and Left Ventricular Hypertrophy in Hemodialysis Patients." Clinical Laboratory, vol. 54, no. 5-6, 2008, pp. 145-52.
Petrović D, Obrenović R, Stojimirović B. Cardiac troponins and left ventricular hypertrophy in hemodialysis patients. Clin Lab. 2008;54(5-6):145-52.
Petrović, D., Obrenović, R., & Stojimirović, B. (2008). Cardiac troponins and left ventricular hypertrophy in hemodialysis patients. Clinical Laboratory, 54(5-6), 145-52.
Petrović D, Obrenović R, Stojimirović B. Cardiac Troponins and Left Ventricular Hypertrophy in Hemodialysis Patients. Clin Lab. 2008;54(5-6):145-52. PubMed PMID: 18780659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac troponins and left ventricular hypertrophy in hemodialysis patients. AU - Petrović,Dejan, AU - Obrenović,Radmila, AU - Stojimirović,Biljana, PY - 2008/9/11/pubmed PY - 2008/10/24/medline PY - 2008/9/11/entrez SP - 145 EP - 52 JF - Clinical laboratory JO - Clin Lab VL - 54 IS - 5-6 N2 - BACKGROUND: Cardiovascular diseases are the leading cause of death in hemodialysis patients. Left ventricular (LV) hypertrophy is an important predictor of cardiovascular morbidity and mortality in these patients. Cardiac troponins (cTnT and cTnI) are indicators of myocardial cell damage. AIM: The aim of this study was to determine prevalence of LV hypertrophy, prevalence of elevated serum cTnT and cTnI in hemodialysis patients, and identify the correlation between cardiac troponins and LV hypertrophy. METHODS: The study included 115 hemodialysis patients (71 men and 44 women), mean age 53.30 +/- 12.17 years, mean time on dialysis 4.51 +/- 4.01 years and average Kt/Vsp 1.17 +/- 0.23. Mean serum cTnT was 0.14 +/- 0.23 ng/ml, mean serum troponin I 0.20 +/- 0.48 ng/ml. Mean LV posterior wall thickness in diastole (LVPWd) was 11.44 +/- 2.09 mm, mean LV interventricular septal wall thickness in diastole (IVSd) 11.21 +/- 2.12 mm, mean LV end diastolic volume index (iLVEDV) 100.80 +/- 34.62 mL/m2 and mean LV mass index (LVMi) 143.85 +/- 41.21 g/m2. RESULTS: We found statistically significant positive correlations (p <0.05) between serum troponin T concentration, IVSd, LVPWd and iLVEDV. A highly significant positive correlation (p < 0.01) was found between serum troponin T and LVMi. One-year follow-up showed that patients with cardiac troponin T > 0.10 ng/ml and cardiac troponin I > 0.15 ng/ml had significantly lower (p < 0.01) survival rate than patients with troponin T < or = 0.10 ng/ml and troponin I < or = 0.15 ng/ml. CONCLUSION: A significant positive correlation exists between serum troponin T concentration and echocardiographic indicators of LV hypertrophy in hemodialysis patients. Patients with higher serum levels of cardiac troponins have lower survival rates during one year follow up. SN - 1433-6510 UR - https://www.unboundmedicine.com/medline/citation/18780659/Cardiac_troponins_and_left_ventricular_hypertrophy_in_hemodialysis_patients_ L2 - https://medlineplus.gov/dialysis.html DB - PRIME DP - Unbound Medicine ER -