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Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer's disease.
J Alzheimers Dis 2008; 15(1):117-28JA

Abstract

Oxidative stress has been shown to be a triggering event in the pathogenesis of Alzheimer's disease (AD). However, little evidence exists on the role of oxidative imbalance in Mild Cognitive Impairment (MCI), a group with a high risk of progression to AD. We therefore assessed the peripheral blood levels of a broad spectrum of non-enzymatic and enzymatic antioxidant defenses, as well as lipid and protein oxidation markers and nitrogen oxidative species in 85 MCI patients, 42 mild AD patients and 37 age-matched controls. In mild AD patients, the plasma levels of vitamin E were significantly decreased, while the plasma concentration of oxidized glutathione was increased in both MCI and mild AD patients. An increase in plasmatic and erythrocytes oxidative markers was also observed in MCI and mild AD patients as compared to controls. In both patients groups, increased levels of plasma antioxidants were found in females, whereas apolipoprotein E epsilon4 allele carriers showed higher indices of intracellular oxidative markers. Moreover, in MCI patients, cognitive function positively correlates with antioxidant levels. This study shows that most of the oxidative changes found in mild AD patients are already present in the MCI group, and that progression to AD might be accompanied by antioxidant depletion.

Authors+Show Affiliations

Laboratory of Neurochemistry, Neurology Department, Coimbra University Hospital, Coimbra, Portugal. ines.baldeiras@sapo.ptNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18780972

Citation

Baldeiras, Inês, et al. "Peripheral Oxidative Damage in Mild Cognitive Impairment and Mild Alzheimer's Disease." Journal of Alzheimer's Disease : JAD, vol. 15, no. 1, 2008, pp. 117-28.
Baldeiras I, Santana I, Proença MT, et al. Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer's disease. J Alzheimers Dis. 2008;15(1):117-28.
Baldeiras, I., Santana, I., Proença, M. T., Garrucho, M. H., Pascoal, R., Rodrigues, A., ... Oliveira, C. R. (2008). Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer's disease. Journal of Alzheimer's Disease : JAD, 15(1), pp. 117-28.
Baldeiras I, et al. Peripheral Oxidative Damage in Mild Cognitive Impairment and Mild Alzheimer's Disease. J Alzheimers Dis. 2008;15(1):117-28. PubMed PMID: 18780972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer's disease. AU - Baldeiras,Inês, AU - Santana,Isabel, AU - Proença,Maria Teresa, AU - Garrucho,Maria Helena, AU - Pascoal,Rui, AU - Rodrigues,Ana, AU - Duro,Diana, AU - Oliveira,Catarina Resende, PY - 2008/9/11/pubmed PY - 2008/11/19/medline PY - 2008/9/11/entrez SP - 117 EP - 28 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 15 IS - 1 N2 - Oxidative stress has been shown to be a triggering event in the pathogenesis of Alzheimer's disease (AD). However, little evidence exists on the role of oxidative imbalance in Mild Cognitive Impairment (MCI), a group with a high risk of progression to AD. We therefore assessed the peripheral blood levels of a broad spectrum of non-enzymatic and enzymatic antioxidant defenses, as well as lipid and protein oxidation markers and nitrogen oxidative species in 85 MCI patients, 42 mild AD patients and 37 age-matched controls. In mild AD patients, the plasma levels of vitamin E were significantly decreased, while the plasma concentration of oxidized glutathione was increased in both MCI and mild AD patients. An increase in plasmatic and erythrocytes oxidative markers was also observed in MCI and mild AD patients as compared to controls. In both patients groups, increased levels of plasma antioxidants were found in females, whereas apolipoprotein E epsilon4 allele carriers showed higher indices of intracellular oxidative markers. Moreover, in MCI patients, cognitive function positively correlates with antioxidant levels. This study shows that most of the oxidative changes found in mild AD patients are already present in the MCI group, and that progression to AD might be accompanied by antioxidant depletion. SN - 1387-2877 UR - https://www.unboundmedicine.com/medline/citation/18780972/Peripheral_oxidative_damage_in_mild_cognitive_impairment_and_mild_Alzheimer's_disease_ L2 - https://content.iospress.com/openurl?genre=article&issn=1387-2877&volume=15&issue=1&spage=117 DB - PRIME DP - Unbound Medicine ER -