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The history of dopamine and levodopa in the treatment of Parkinson's disease.
Mov Disord. 2008; 23 Suppl 3:S497-508.MD

Abstract

The discoveries of dopamine as a neurotransmitter in the brain, its depletion in patients with Parkinson disease, and its replacement with levodopa therapy were major revolutionary events in the rise to effective therapy for patients with this disorder. This review describes these events and the persons who carried out these accomplishments. Their impact went beyond a single clinical entity of parkinsonism, for it opened up the beginning of a much better understanding of the role of dopamine in other neurologic movement disorders and also in many psychiatric diseases.

Authors+Show Affiliations

Columbia University, New York, USA. fahn@neuro.columbia.edu

Pub Type(s)

Historical Article
Journal Article
Review

Language

eng

PubMed ID

18781671

Citation

Fahn, Stanley. "The History of Dopamine and Levodopa in the Treatment of Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 23 Suppl 3, 2008, pp. S497-508.
Fahn S. The history of dopamine and levodopa in the treatment of Parkinson's disease. Mov Disord. 2008;23 Suppl 3:S497-508.
Fahn, S. (2008). The history of dopamine and levodopa in the treatment of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 23 Suppl 3, S497-508. https://doi.org/10.1002/mds.22028
Fahn S. The History of Dopamine and Levodopa in the Treatment of Parkinson's Disease. Mov Disord. 2008;23 Suppl 3:S497-508. PubMed PMID: 18781671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The history of dopamine and levodopa in the treatment of Parkinson's disease. A1 - Fahn,Stanley, PY - 2008/9/11/pubmed PY - 2009/2/14/medline PY - 2008/9/11/entrez SP - S497 EP - 508 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 23 Suppl 3 N2 - The discoveries of dopamine as a neurotransmitter in the brain, its depletion in patients with Parkinson disease, and its replacement with levodopa therapy were major revolutionary events in the rise to effective therapy for patients with this disorder. This review describes these events and the persons who carried out these accomplishments. Their impact went beyond a single clinical entity of parkinsonism, for it opened up the beginning of a much better understanding of the role of dopamine in other neurologic movement disorders and also in many psychiatric diseases. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/18781671/The_history_of_dopamine_and_levodopa_in_the_treatment_of_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.22028 DB - PRIME DP - Unbound Medicine ER -