Tags

Type your tag names separated by a space and hit enter

Treatment of levodopa-induced motor complications.
Mov Disord. 2008; 23 Suppl 3:S599-612.MD

Abstract

Chronic levodopa treatment for Parkinson's disease patients is frequently associated with the development of motor complications such as end-of-dose wearing-off and dyskinesias. In this review, we provide an overview of the strategies available for dealing with these problems. Medical management includes manipulation of levodopa dosing to establish the optimum treatment schedule, improving levodopa absorption, catechol-O-methyl transferase-inhibition (COMT), Monoamine oxidase-B (MAO-B) inhibition, dopaminergic agonists, amantadine, and continuous dopaminergic infusions. Surgical procedures and particularly deep brain stimulation are also reviewed. It should be noted that none of these treatments has been shown to provide anti-parkinsonian efficacy that is greater than what can be achieved with levodopa. We highlight the importance of initiating therapy with a treatment strategy that reduces the risk that a Parkinson's disease patient will develop motor complications in the first place. Key Words: Advanced PD, dyskinesias, motor fluctuations, levodopa, dopamine agonists, COMT inhibitors, MAO-B inhibitors.

Authors+Show Affiliations

IRCCS San Raffaele, Via della Pisana 235, Roma, Italy. fabrizio.stocchi@fastwebnet.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18781681

Citation

Stocchi, Fabrizio, et al. "Treatment of Levodopa-induced Motor Complications." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 23 Suppl 3, 2008, pp. S599-612.
Stocchi F, Tagliati M, Olanow CW. Treatment of levodopa-induced motor complications. Mov Disord. 2008;23 Suppl 3:S599-612.
Stocchi, F., Tagliati, M., & Olanow, C. W. (2008). Treatment of levodopa-induced motor complications. Movement Disorders : Official Journal of the Movement Disorder Society, 23 Suppl 3, S599-612. https://doi.org/10.1002/mds.22052
Stocchi F, Tagliati M, Olanow CW. Treatment of Levodopa-induced Motor Complications. Mov Disord. 2008;23 Suppl 3:S599-612. PubMed PMID: 18781681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of levodopa-induced motor complications. AU - Stocchi,Fabrizio, AU - Tagliati,Michele, AU - Olanow,C Warren, PY - 2008/9/11/pubmed PY - 2009/2/14/medline PY - 2008/9/11/entrez SP - S599 EP - 612 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 23 Suppl 3 N2 - Chronic levodopa treatment for Parkinson's disease patients is frequently associated with the development of motor complications such as end-of-dose wearing-off and dyskinesias. In this review, we provide an overview of the strategies available for dealing with these problems. Medical management includes manipulation of levodopa dosing to establish the optimum treatment schedule, improving levodopa absorption, catechol-O-methyl transferase-inhibition (COMT), Monoamine oxidase-B (MAO-B) inhibition, dopaminergic agonists, amantadine, and continuous dopaminergic infusions. Surgical procedures and particularly deep brain stimulation are also reviewed. It should be noted that none of these treatments has been shown to provide anti-parkinsonian efficacy that is greater than what can be achieved with levodopa. We highlight the importance of initiating therapy with a treatment strategy that reduces the risk that a Parkinson's disease patient will develop motor complications in the first place. Key Words: Advanced PD, dyskinesias, motor fluctuations, levodopa, dopamine agonists, COMT inhibitors, MAO-B inhibitors. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/18781681/Treatment_of_levodopa_induced_motor_complications_ L2 - https://doi.org/10.1002/mds.22052 DB - PRIME DP - Unbound Medicine ER -