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Variations in the UDP-glucuronosyltransferase 1A1 gene for the development of unconjugated hyperbilirubinemia in Taiwanese.
Pharmacogenomics. 2008 Sep; 9(9):1229-35.P

Abstract

INTRODUCTION

Results of several studies have indicated that the variation of c.-3279T>G in the UDP-glucuronosyltransferase (UGT)1A1 gene could be a further factor for the development of hyperbilirubinemia. However, this variant has not been reported in the Taiwanese population.

MATERIALS & METHODS

PCR-restriction fragment length polymorphism was utilized to determine variants at nucleotides -3279 (*60), -53 (*28) and 211 (*6) in the UGT1A1 gene for 178 Taiwanese hyperbilirubinemic patients and 200 controls.

RESULTS

A total of ten and nine diplotypes were observed in the hyperbilirubinemic patients and controls, respectively. Subjects possessing diplotypes of compound haplotypes (*60/*28, *60/*6, *1/*60 plus *1/*28 plus *1/*6); *60/*60; *60/*60 plus 1/*28 and *6/*6 were significantly related to hyperbilirubinemia development, with an odds ratio of 7.83-188.00 (p = 0.012 approximately <0.001). A subgroup possessing diplotypes of *60/*60 plus *28/*28 were only found in hyperbilirubinemic patients, not in the controls. Bilirubin concentration amongst these patients carrying a diplotype of *60/*60 plus *28/*28 (mean [SD]: 39.2 [10.77] micromol/l) was significantly higher than that in the diplotype subgroups of *60/*60 plus *1/*28 (30.4 [4.10] micromol/l) and *6/*6 (30.3 [3.08] micromol/l) (p = 0.046 and 0.034, respectively).

CONCLUSIONS

The c.-3279T>G variant is a further factor for the development of hyperbilirubinemia. Our results also demonstrate that possessing the *60/*60 plus *28/*28 diplotype in the UGT1A1 gene is a determinant of relatively higher bilirubin values amongst hyperbilirubinemic patients.

Authors+Show Affiliations

Department of Laboratory Medicine, Cathay General Hospital, No 280, Section 4, Jen-Ai Road, Taipei 106, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18781851

Citation

Huang, Yang-Yang, et al. "Variations in the UDP-glucuronosyltransferase 1A1 Gene for the Development of Unconjugated Hyperbilirubinemia in Taiwanese." Pharmacogenomics, vol. 9, no. 9, 2008, pp. 1229-35.
Huang YY, Huang MJ, Yang SS, et al. Variations in the UDP-glucuronosyltransferase 1A1 gene for the development of unconjugated hyperbilirubinemia in Taiwanese. Pharmacogenomics. 2008;9(9):1229-35.
Huang, Y. Y., Huang, M. J., Yang, S. S., Teng, H. C., & Huang, C. S. (2008). Variations in the UDP-glucuronosyltransferase 1A1 gene for the development of unconjugated hyperbilirubinemia in Taiwanese. Pharmacogenomics, 9(9), 1229-35. https://doi.org/10.2217/14622416.9.9.1229
Huang YY, et al. Variations in the UDP-glucuronosyltransferase 1A1 Gene for the Development of Unconjugated Hyperbilirubinemia in Taiwanese. Pharmacogenomics. 2008;9(9):1229-35. PubMed PMID: 18781851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variations in the UDP-glucuronosyltransferase 1A1 gene for the development of unconjugated hyperbilirubinemia in Taiwanese. AU - Huang,Yang-Yang, AU - Huang,May-Jen, AU - Yang,Sieng-Sien, AU - Teng,Hsiu-Chen, AU - Huang,Ching-Shan, PY - 2008/9/11/pubmed PY - 2009/1/13/medline PY - 2008/9/11/entrez SP - 1229 EP - 35 JF - Pharmacogenomics JO - Pharmacogenomics VL - 9 IS - 9 N2 - INTRODUCTION: Results of several studies have indicated that the variation of c.-3279T>G in the UDP-glucuronosyltransferase (UGT)1A1 gene could be a further factor for the development of hyperbilirubinemia. However, this variant has not been reported in the Taiwanese population. MATERIALS & METHODS: PCR-restriction fragment length polymorphism was utilized to determine variants at nucleotides -3279 (*60), -53 (*28) and 211 (*6) in the UGT1A1 gene for 178 Taiwanese hyperbilirubinemic patients and 200 controls. RESULTS: A total of ten and nine diplotypes were observed in the hyperbilirubinemic patients and controls, respectively. Subjects possessing diplotypes of compound haplotypes (*60/*28, *60/*6, *1/*60 plus *1/*28 plus *1/*6); *60/*60; *60/*60 plus 1/*28 and *6/*6 were significantly related to hyperbilirubinemia development, with an odds ratio of 7.83-188.00 (p = 0.012 approximately <0.001). A subgroup possessing diplotypes of *60/*60 plus *28/*28 were only found in hyperbilirubinemic patients, not in the controls. Bilirubin concentration amongst these patients carrying a diplotype of *60/*60 plus *28/*28 (mean [SD]: 39.2 [10.77] micromol/l) was significantly higher than that in the diplotype subgroups of *60/*60 plus *1/*28 (30.4 [4.10] micromol/l) and *6/*6 (30.3 [3.08] micromol/l) (p = 0.046 and 0.034, respectively). CONCLUSIONS: The c.-3279T>G variant is a further factor for the development of hyperbilirubinemia. Our results also demonstrate that possessing the *60/*60 plus *28/*28 diplotype in the UGT1A1 gene is a determinant of relatively higher bilirubin values amongst hyperbilirubinemic patients. SN - 1744-8042 UR - https://www.unboundmedicine.com/medline/citation/18781851/Variations_in_the_UDP_glucuronosyltransferase_1A1_gene_for_the_development_of_unconjugated_hyperbilirubinemia_in_Taiwanese_ L2 - http://www.futuremedicine.com/doi/full/10.2217/14622416.9.9.1229?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -