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Diagnosis of coccidioidomycosis with use of the Coccidioides antigen enzyme immunoassay.
Clin Infect Dis. 2008 Oct 15; 47(8):e69-73.CI

Abstract

BACKGROUND

We have previously shown antigenuria in patients with coccidioidomycosis through use of the Histoplasma antigen enzyme immunoassay (EIA), and now we have developed a specific Coccidioides antigen EIA.

METHODS

The Coccidioides EIA uses antibodies to Coccidioides galactomannan. The sensitivity of the Coccidioides and Histoplasma EIAs was evaluated in patients with more-severe coccidioidomycosis, and the specificity of these EIAs was evaluated in patients with nonfungal infections, in patients with other endemic mycoses, and in healthy individuals.

RESULTS

Among patients in the present study, antigenuria was detected in 70.8% of patients with coccidioidomycosis with use of the Coccidioides EIA and in 58.3% of patients with use of the Histoplasma EIA. Antigenuria was absent in 99.4% of healthy individuals, patients with nonfungal infections, and patients with noninfectious conditions. Cross-reactions with other endemic mycoses were observed in 10.7% of patients.

CONCLUSIONS

The Coccidioides EIA has potential to be useful in the rapid diagnosis of more-severe forms of coccidioidomycosis.

Authors+Show Affiliations

MiraVista Diagnostics, Indianapolis, Indiana 46241, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18781884

Citation

Durkin, Michelle, et al. "Diagnosis of Coccidioidomycosis With Use of the Coccidioides Antigen Enzyme Immunoassay." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 47, no. 8, 2008, pp. e69-73.
Durkin M, Connolly P, Kuberski T, et al. Diagnosis of coccidioidomycosis with use of the Coccidioides antigen enzyme immunoassay. Clin Infect Dis. 2008;47(8):e69-73.
Durkin, M., Connolly, P., Kuberski, T., Myers, R., Kubak, B. M., Bruckner, D., Pegues, D., & Wheat, L. J. (2008). Diagnosis of coccidioidomycosis with use of the Coccidioides antigen enzyme immunoassay. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 47(8), e69-73. https://doi.org/10.1086/592073
Durkin M, et al. Diagnosis of Coccidioidomycosis With Use of the Coccidioides Antigen Enzyme Immunoassay. Clin Infect Dis. 2008 Oct 15;47(8):e69-73. PubMed PMID: 18781884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of coccidioidomycosis with use of the Coccidioides antigen enzyme immunoassay. AU - Durkin,Michelle, AU - Connolly,Patricia, AU - Kuberski,Tim, AU - Myers,Robert, AU - Kubak,Bernard M, AU - Bruckner,David, AU - Pegues,David, AU - Wheat,L Joseph, PY - 2008/9/11/pubmed PY - 2008/10/24/medline PY - 2008/9/11/entrez SP - e69 EP - 73 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 47 IS - 8 N2 - BACKGROUND: We have previously shown antigenuria in patients with coccidioidomycosis through use of the Histoplasma antigen enzyme immunoassay (EIA), and now we have developed a specific Coccidioides antigen EIA. METHODS: The Coccidioides EIA uses antibodies to Coccidioides galactomannan. The sensitivity of the Coccidioides and Histoplasma EIAs was evaluated in patients with more-severe coccidioidomycosis, and the specificity of these EIAs was evaluated in patients with nonfungal infections, in patients with other endemic mycoses, and in healthy individuals. RESULTS: Among patients in the present study, antigenuria was detected in 70.8% of patients with coccidioidomycosis with use of the Coccidioides EIA and in 58.3% of patients with use of the Histoplasma EIA. Antigenuria was absent in 99.4% of healthy individuals, patients with nonfungal infections, and patients with noninfectious conditions. Cross-reactions with other endemic mycoses were observed in 10.7% of patients. CONCLUSIONS: The Coccidioides EIA has potential to be useful in the rapid diagnosis of more-severe forms of coccidioidomycosis. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/18781884/Diagnosis_of_coccidioidomycosis_with_use_of_the_Coccidioides_antigen_enzyme_immunoassay_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/592073 DB - PRIME DP - Unbound Medicine ER -