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The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses.
Curr Pharm Des. 2008; 14(23):2299-3305.CP

Abstract

Unlike other neuroinflammatory disorders, like Parkinson's disease, Huntington's disease and multiple sclerosis, little is still known of the role of the endocannabinoid system in Alzheimer's disease (AD). This is partly due to the poor availability of animal models that are really relevant to the human disease, and to the complexity of AD as compared to other neurological states. Nevertheless, the available data indicate that endocannabinoids are likely to play in this disorder a role similar to that suggested in other neurodegenerative diseases, that is, to represent an endogenous adaptive response aimed at counteracting both the neurochemical and inflammatory consequences of beta-amyloid-induced tau protein hyperactivity, possibly the most important underlying cause of AD. Furthermore, plant and synthetic cannabinoids, and particularly the non-psychotropic cannabidiol, might also exert other, non-cannabinoid receptor-mediated protective effects, including, but not limited to, anti-oxidant actions. There is evidence, from in vivo studies on beta-amyloid-induced neurotoxicity, also for a possible causative role of endocannabinoids in the impairment in memory retention, which is typical of AD. This might open the way to the use of cannabinoid receptor antagonists as therapeutic drugs for the treatment of cognitive deficits in the more advanced phases of this disorder. The scant, but nevertheless important literature on the regulation and role of the endocannabinoid system in AD, and on the potential treatment of this disorder with cannabinoids and endocannabinoid-based drugs, are discussed in this mini-review.

Authors+Show Affiliations

Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli (Naples), Italy.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18781980

Citation

Bisogno, Tiziana, and Vincenzo Di Marzo. "The Role of the Endocannabinoid System in Alzheimer's Disease: Facts and Hypotheses." Current Pharmaceutical Design, vol. 14, no. 23, 2008, pp. 2299-3305.
Bisogno T, Di Marzo V. The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses. Curr Pharm Des. 2008;14(23):2299-3305.
Bisogno, T., & Di Marzo, V. (2008). The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses. Current Pharmaceutical Design, 14(23), 2299-3305.
Bisogno T, Di Marzo V. The Role of the Endocannabinoid System in Alzheimer's Disease: Facts and Hypotheses. Curr Pharm Des. 2008;14(23):2299-3305. PubMed PMID: 18781980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses. AU - Bisogno,Tiziana, AU - Di Marzo,Vincenzo, PY - 2008/9/11/pubmed PY - 2008/11/18/medline PY - 2008/9/11/entrez SP - 2299 EP - 3305 JF - Current pharmaceutical design JO - Curr. Pharm. Des. VL - 14 IS - 23 N2 - Unlike other neuroinflammatory disorders, like Parkinson's disease, Huntington's disease and multiple sclerosis, little is still known of the role of the endocannabinoid system in Alzheimer's disease (AD). This is partly due to the poor availability of animal models that are really relevant to the human disease, and to the complexity of AD as compared to other neurological states. Nevertheless, the available data indicate that endocannabinoids are likely to play in this disorder a role similar to that suggested in other neurodegenerative diseases, that is, to represent an endogenous adaptive response aimed at counteracting both the neurochemical and inflammatory consequences of beta-amyloid-induced tau protein hyperactivity, possibly the most important underlying cause of AD. Furthermore, plant and synthetic cannabinoids, and particularly the non-psychotropic cannabidiol, might also exert other, non-cannabinoid receptor-mediated protective effects, including, but not limited to, anti-oxidant actions. There is evidence, from in vivo studies on beta-amyloid-induced neurotoxicity, also for a possible causative role of endocannabinoids in the impairment in memory retention, which is typical of AD. This might open the way to the use of cannabinoid receptor antagonists as therapeutic drugs for the treatment of cognitive deficits in the more advanced phases of this disorder. The scant, but nevertheless important literature on the regulation and role of the endocannabinoid system in AD, and on the potential treatment of this disorder with cannabinoids and endocannabinoid-based drugs, are discussed in this mini-review. SN - 1873-4286 UR - https://www.unboundmedicine.com/medline/citation/18781980/The_role_of_the_endocannabinoid_system_in_Alzheimer's_disease:_facts_and_hypotheses_ L2 - http://www.eurekaselect.com/67568/article DB - PRIME DP - Unbound Medicine ER -