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Are anti-beta-glycoprotein-I antibodies markers for recurrent pregnancy loss in lupus anticoagulant/anticardiolipin seronegative women?
Am J Reprod Immunol. 2008 Sep; 60(3):229-37.AJ

Abstract

PROBLEM

Anti-beta(2)-Glicoprotein-1 antibodies (anti-beta(2)GPI-ab) have been related to recurrent miscarriage (RM) with conflicting results. The aim was to evaluate the role of anti-beta(2)-GPI-ab as unique biological marker in RM related to antiphospholipid (aPL).

METHOD OF STUDY

A cohort study that included 59 cases, divided in two groups, was designed: group 1 comprised 43 pregnant women with 'obstetric' antiphospholipid syndrome (APS) and group 2 included 16 cases with similar complaints but only having repeatedly anti-beta(2)-GPI-ab. Previous thrombosis and/or inherited thrombophilia were excluded. Lupus anticoagulant, anticardiolipin antibodies (aCA), anti-beta(2)-GPI-ab, and other autoantibodies were analyzed. Miscarriages, premature births, pre-eclampsia, live births, placental and systemic thromboses were studied.

RESULTS

No differences in previous obstetric complications were detected (P = 1.00-0.164). After the treatment, differences in number of obstetric complications were not seen (P = 1.00). Live births were similar in two groups (88.4% and 93.7%; P = 1.00). Placental thrombosis was equal in both groups, 93.3% versus 80% (P = 1.00).

CONCLUSION

These results suggest that anti-beta(2)-GPI-ab may be considered a biological marker for obstetric APS.

Authors+Show Affiliations

Systemic Autoimmune Disease Unit, Department of Internal Medicine I, Hospital Universitari Vall d'Hebron, Barcelona, Spain. 16297jar@comb.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18782284

Citation

Alijotas-Reig, Jaume, et al. "Are anti-beta-glycoprotein-I Antibodies Markers for Recurrent Pregnancy Loss in Lupus Anticoagulant/anticardiolipin Seronegative Women?" American Journal of Reproductive Immunology (New York, N.Y. : 1989), vol. 60, no. 3, 2008, pp. 229-37.
Alijotas-Reig J, Casellas-Caro M, Ferrer-Oliveras R, et al. Are anti-beta-glycoprotein-I antibodies markers for recurrent pregnancy loss in lupus anticoagulant/anticardiolipin seronegative women? Am J Reprod Immunol. 2008;60(3):229-37.
Alijotas-Reig, J., Casellas-Caro, M., Ferrer-Oliveras, R., Llurba-Olive, E., Hermosilla, E., Vilardell-Tarres, M., & Cabero-Roura, L. (2008). Are anti-beta-glycoprotein-I antibodies markers for recurrent pregnancy loss in lupus anticoagulant/anticardiolipin seronegative women? American Journal of Reproductive Immunology (New York, N.Y. : 1989), 60(3), 229-37. https://doi.org/10.1111/j.1600-0897.2008.00618.x
Alijotas-Reig J, et al. Are anti-beta-glycoprotein-I Antibodies Markers for Recurrent Pregnancy Loss in Lupus Anticoagulant/anticardiolipin Seronegative Women. Am J Reprod Immunol. 2008;60(3):229-37. PubMed PMID: 18782284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are anti-beta-glycoprotein-I antibodies markers for recurrent pregnancy loss in lupus anticoagulant/anticardiolipin seronegative women? AU - Alijotas-Reig,Jaume, AU - Casellas-Caro,Manel, AU - Ferrer-Oliveras,Raquel, AU - Llurba-Olive,Elisa, AU - Hermosilla,Eduard, AU - Vilardell-Tarres,Miquel, AU - Cabero-Roura,Lluis, PY - 2008/9/11/pubmed PY - 2008/10/15/medline PY - 2008/9/11/entrez SP - 229 EP - 37 JF - American journal of reproductive immunology (New York, N.Y. : 1989) JO - Am J Reprod Immunol VL - 60 IS - 3 N2 - PROBLEM: Anti-beta(2)-Glicoprotein-1 antibodies (anti-beta(2)GPI-ab) have been related to recurrent miscarriage (RM) with conflicting results. The aim was to evaluate the role of anti-beta(2)-GPI-ab as unique biological marker in RM related to antiphospholipid (aPL). METHOD OF STUDY: A cohort study that included 59 cases, divided in two groups, was designed: group 1 comprised 43 pregnant women with 'obstetric' antiphospholipid syndrome (APS) and group 2 included 16 cases with similar complaints but only having repeatedly anti-beta(2)-GPI-ab. Previous thrombosis and/or inherited thrombophilia were excluded. Lupus anticoagulant, anticardiolipin antibodies (aCA), anti-beta(2)-GPI-ab, and other autoantibodies were analyzed. Miscarriages, premature births, pre-eclampsia, live births, placental and systemic thromboses were studied. RESULTS: No differences in previous obstetric complications were detected (P = 1.00-0.164). After the treatment, differences in number of obstetric complications were not seen (P = 1.00). Live births were similar in two groups (88.4% and 93.7%; P = 1.00). Placental thrombosis was equal in both groups, 93.3% versus 80% (P = 1.00). CONCLUSION: These results suggest that anti-beta(2)-GPI-ab may be considered a biological marker for obstetric APS. SN - 1046-7408 UR - https://www.unboundmedicine.com/medline/citation/18782284/Are_anti_beta_glycoprotein_I_antibodies_markers_for_recurrent_pregnancy_loss_in_lupus_anticoagulant/anticardiolipin_seronegative_women L2 - https://doi.org/10.1111/j.1600-0897.2008.00618.x DB - PRIME DP - Unbound Medicine ER -