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Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells.
New Biol. 1991 Mar; 3(3):289-96.NB

Abstract

To investigate the regulation of genes whose expression is enriched in liver we studied expression of the albumin and transthyretin (TTR) genes in a series of rat hepatoma cell lines (FaO, C2, C2rev7, and H5) that express these genes at different rates. The level of expression of albumin and TTR was compared to the expression and DNA-binding activity of four transcription factors, HNF1/LFB1, C/EBP, HNF3, and HNF4, that are found at high concentrations in liver. We conclude that the levels of these factors are controlled both transcriptionally (HNF-3, HNF-4, and C/EBP) and post-transcriptionally (HNF-1/LFB1), and that the cellular concentration of these DNA-binding proteins helps explain the level of transcriptional activity observed for the genes they regulate.

Authors+Show Affiliations

Rockefeller University, New York, NY 10021.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1878351

Citation

Herbst, R S., et al. "Differential Regulation of Hepatocyte-enriched Transcription Factors Explains Changes in Albumin and Transthyretin Gene Expression Among Hepatoma Cells." The New Biologist, vol. 3, no. 3, 1991, pp. 289-96.
Herbst RS, Nielsch U, Sladek F, et al. Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells. New Biol. 1991;3(3):289-96.
Herbst, R. S., Nielsch, U., Sladek, F., Lai, E., Babiss, L. E., & Darnell, J. E. (1991). Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells. The New Biologist, 3(3), 289-96.
Herbst RS, et al. Differential Regulation of Hepatocyte-enriched Transcription Factors Explains Changes in Albumin and Transthyretin Gene Expression Among Hepatoma Cells. New Biol. 1991;3(3):289-96. PubMed PMID: 1878351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells. AU - Herbst,R S, AU - Nielsch,U, AU - Sladek,F, AU - Lai,E, AU - Babiss,L E, AU - Darnell,J E,Jr PY - 1991/3/11/pubmed PY - 2001/3/28/medline PY - 1991/3/11/entrez SP - 289 EP - 96 JF - The New biologist JO - New Biol VL - 3 IS - 3 N2 - To investigate the regulation of genes whose expression is enriched in liver we studied expression of the albumin and transthyretin (TTR) genes in a series of rat hepatoma cell lines (FaO, C2, C2rev7, and H5) that express these genes at different rates. The level of expression of albumin and TTR was compared to the expression and DNA-binding activity of four transcription factors, HNF1/LFB1, C/EBP, HNF3, and HNF4, that are found at high concentrations in liver. We conclude that the levels of these factors are controlled both transcriptionally (HNF-3, HNF-4, and C/EBP) and post-transcriptionally (HNF-1/LFB1), and that the cellular concentration of these DNA-binding proteins helps explain the level of transcriptional activity observed for the genes they regulate. SN - 1043-4674 UR - https://www.unboundmedicine.com/medline/citation/1878351/Differential_regulation_of_hepatocyte_enriched_transcription_factors_explains_changes_in_albumin_and_transthyretin_gene_expression_among_hepatoma_cells_ L2 - https://antibodies.cancer.gov/detail/CPTC-TTR-1 DB - PRIME DP - Unbound Medicine ER -