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The advantages of topical combination therapy in the treatment of inflammatory dermatomycoses.
Mycoses. 2008 Sep; 51 Suppl 4:16-26.M

Abstract

Dermatomycoses are contagious superficial fungal infections, which are highly prevalent in developed and developing countries. Caused by a range of Epidermophyton, Microsporum and Trichophyton species, dermatomycoses manifest on glabrous skin as 'ringworm', an annular scaly lesion with a variable inflammatory component. Itch is the chief subjective symptom, particularly in tinea cruris. Unless lesions are extensive or resistant to local therapy, dermatomycoses of glabrous skin are treated with topical antifungal agents, such as imidazoles and allylamines. Studies show, however, that the addition of a topical corticosteroid to imidazole therapy increases the bioavailability and prolongs the activity of the antimycotic, while rapidly reducing inflammatory symptoms. Travocort is a combination of 1% isoconazole nitrate (ISN), a broad-spectrum imidazole with established antimicrobial activity and antimycotic efficacy, and 0.1% diflucortolone valerate (DFV), a potent topical corticosteroid with low systemic absorption and therefore a low risk of systemic glucocorticoid side-effects. In randomised, double-blind controlled clinical trials, Travocort therapy showed a more rapid onset of action, faster relief of itch and other inflammatory symptoms, improved overall therapeutic benefits and better mycological cure rate during the first 2 weeks of treatment compared with ISN monotherapy. Travocort is well tolerated and, because of prolonged ISN retention in the skin, provides antifungal protection against reinfection for some weeks after therapy.

Authors+Show Affiliations

Global Clinical Development, Intendis GmbH, Berlin, Germany. blanka.havlickova@intendis.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18783560

Citation

Havlickova, Blanka, and Markus Friedrich. "The Advantages of Topical Combination Therapy in the Treatment of Inflammatory Dermatomycoses." Mycoses, vol. 51 Suppl 4, 2008, pp. 16-26.
Havlickova B, Friedrich M. The advantages of topical combination therapy in the treatment of inflammatory dermatomycoses. Mycoses. 2008;51 Suppl 4:16-26.
Havlickova, B., & Friedrich, M. (2008). The advantages of topical combination therapy in the treatment of inflammatory dermatomycoses. Mycoses, 51 Suppl 4, 16-26. https://doi.org/10.1111/j.1439-0507.2008.01615.x
Havlickova B, Friedrich M. The Advantages of Topical Combination Therapy in the Treatment of Inflammatory Dermatomycoses. Mycoses. 2008;51 Suppl 4:16-26. PubMed PMID: 18783560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The advantages of topical combination therapy in the treatment of inflammatory dermatomycoses. AU - Havlickova,Blanka, AU - Friedrich,Markus, PY - 2008/9/12/pubmed PY - 2008/10/24/medline PY - 2008/9/12/entrez SP - 16 EP - 26 JF - Mycoses JO - Mycoses VL - 51 Suppl 4 N2 - Dermatomycoses are contagious superficial fungal infections, which are highly prevalent in developed and developing countries. Caused by a range of Epidermophyton, Microsporum and Trichophyton species, dermatomycoses manifest on glabrous skin as 'ringworm', an annular scaly lesion with a variable inflammatory component. Itch is the chief subjective symptom, particularly in tinea cruris. Unless lesions are extensive or resistant to local therapy, dermatomycoses of glabrous skin are treated with topical antifungal agents, such as imidazoles and allylamines. Studies show, however, that the addition of a topical corticosteroid to imidazole therapy increases the bioavailability and prolongs the activity of the antimycotic, while rapidly reducing inflammatory symptoms. Travocort is a combination of 1% isoconazole nitrate (ISN), a broad-spectrum imidazole with established antimicrobial activity and antimycotic efficacy, and 0.1% diflucortolone valerate (DFV), a potent topical corticosteroid with low systemic absorption and therefore a low risk of systemic glucocorticoid side-effects. In randomised, double-blind controlled clinical trials, Travocort therapy showed a more rapid onset of action, faster relief of itch and other inflammatory symptoms, improved overall therapeutic benefits and better mycological cure rate during the first 2 weeks of treatment compared with ISN monotherapy. Travocort is well tolerated and, because of prolonged ISN retention in the skin, provides antifungal protection against reinfection for some weeks after therapy. SN - 1439-0507 UR - https://www.unboundmedicine.com/medline/citation/18783560/The_advantages_of_topical_combination_therapy_in_the_treatment_of_inflammatory_dermatomycoses_ L2 - https://doi.org/10.1111/j.1439-0507.2008.01615.x DB - PRIME DP - Unbound Medicine ER -