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Spinal cryptococcoma in an immunocompetent cat.
J Comp Pathol. 2008 Nov; 139(4):246-51.JC

Abstract

This report describes an unusual case of primary cryptococcoma in the proximal thoracic spinal cord of an 11-year-old immunocompetent cat from a farm on which there were large numbers of pigeons. This animal was referred for examination with progressive paralysis and shown to be free from feline immunodeficiency virus, feline leukaemia virus, feline coronavirus and Toxoplasma gondii. It died 2 months later. At necropsy, the only lesion detected was a malacic area, 4cm in length, in the spinal cord. Histopathological examination of the spinal cord revealed severe granulomatous inflammation associated with large numbers of encapsulated yeast cells. In addition to the granulomatous host response, necrosis, digestion chambers, Gitter cells, spheroids and lymphocytic perivascular cuffs were features of the malacic areas. Immunohistochemistry confirmed the presence of Cryptococcus neoformans var. grubii yeast cells.

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Authors+Show Affiliations

Belluco S
Unité d'Anatomie-Pathologique, UMR 703 INRA/ENVN, Ecole Nationale Vétérinaire de Nantes, France.
Thibaud JL
No affiliation info available
Guillot J
No affiliation info available
Krockenberger MB
No affiliation info available
Wyers M
No affiliation info available
Blot S
No affiliation info available
Colle MA
No affiliation info available

MeSH

AnimalsCat DiseasesCatsCryptococcosisCryptococcus neoformansImmunohistochemistryMaleSpinal Cord DiseasesThoracic Vertebrae

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18783789

Citation

Belluco, S, et al. "Spinal Cryptococcoma in an Immunocompetent Cat." Journal of Comparative Pathology, vol. 139, no. 4, 2008, pp. 246-51.
Belluco S, Thibaud JL, Guillot J, et al. Spinal cryptococcoma in an immunocompetent cat. J Comp Pathol. 2008;139(4):246-51.
Belluco, S., Thibaud, J. L., Guillot, J., Krockenberger, M. B., Wyers, M., Blot, S., & Colle, M. A. (2008). Spinal cryptococcoma in an immunocompetent cat. Journal of Comparative Pathology, 139(4), 246-51. https://doi.org/10.1016/j.jcpa.2008.06.007
Belluco S, et al. Spinal Cryptococcoma in an Immunocompetent Cat. J Comp Pathol. 2008;139(4):246-51. PubMed PMID: 18783789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spinal cryptococcoma in an immunocompetent cat. AU - Belluco,S, AU - Thibaud,J L, AU - Guillot,J, AU - Krockenberger,M B, AU - Wyers,M, AU - Blot,S, AU - Colle,M A, Y1 - 2008/09/09/ PY - 2007/11/30/received PY - 2008/06/23/accepted PY - 2008/9/12/pubmed PY - 2009/2/21/medline PY - 2008/9/12/entrez SP - 246 EP - 51 JF - Journal of comparative pathology JO - J Comp Pathol VL - 139 IS - 4 N2 - This report describes an unusual case of primary cryptococcoma in the proximal thoracic spinal cord of an 11-year-old immunocompetent cat from a farm on which there were large numbers of pigeons. This animal was referred for examination with progressive paralysis and shown to be free from feline immunodeficiency virus, feline leukaemia virus, feline coronavirus and Toxoplasma gondii. It died 2 months later. At necropsy, the only lesion detected was a malacic area, 4cm in length, in the spinal cord. Histopathological examination of the spinal cord revealed severe granulomatous inflammation associated with large numbers of encapsulated yeast cells. In addition to the granulomatous host response, necrosis, digestion chambers, Gitter cells, spheroids and lymphocytic perivascular cuffs were features of the malacic areas. Immunohistochemistry confirmed the presence of Cryptococcus neoformans var. grubii yeast cells. SN - 0021-9975 UR - https://www.unboundmedicine.com/medline/citation/18783789/Spinal_cryptococcoma_in_an_immunocompetent_cat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9975(08)00082-0 DB - PRIME DP - Unbound Medicine ER -